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Acyl chlorides

Organic compounds that contain an acyl group bonded to a chloride ion; an acyl group is a carbon atom bonded to an alkyl functional group, and an oxygen atom via a double bond.

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Medchemexpress LLC QX-314 chloride | 5369-03-9 | 100.0% | 298.85 | 100 MG
SDP

QX-314 chloride is a membrane-impermeable, permanently charged sodium channel blocker. It is intended for research use only.

  • Membrane-impermeable sodium channel blocker
  • Exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels (TRPV1) in vitro
  • Activates TRPV1 in a concentration-dependent manner
  • Inhibits calcium currents in hippocampal CA1 pyramidal neurons intracellularly

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2

Apexbio Technology LLC QX 314 chloride 5369-03-9 10mM (in 1mL DMSO)
SDP

QX 314 chloride (CAS 5369-03-9) is a quaternary lidocaine derivative characterized by low membrane permeability It selectively inhibits voltage-gated sodium (Na sup /sup ) channels on nociceptive neurons when delivered intracellularly Entry into neurons occurs via activation and permeation through the TRPV1 or TRPA1 channel pores often facilitated by co-application with agonists such as capsaicin In nociceptive neurons QX 314 chloride blocks Na sup /sup currents and suppresses excitability whereas it also induces prolonged blockade of motor neuron function This compound is employed in studies of pain signaling selective sensory or motor nerve inhibition and mechanisms of ion channel-mediated drug entry

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