Alkyl chlorides
Medchemexpress LLC 3,5,6-trichloro-2-pyridinol | 6515-38-4 | MFCD00130269 | 99.9% | 198.43 g·mol⁻¹ | C5H2Cl3NO | 1 ML
3,5,6-Trichloro-2-pyridinol is supplied as a 10 mM solution in DMSO (1 mL) for research and analytical use. The compound has CAS 6515-38-4 and a molecular weight of 198.43 g·mol⁻¹. Follow recommended storage guidelines for solution and powder to maintain stability.
- High purity (99.85%).
- Ready-to-use 10 mM solution in DMSO.
- Compact 1 mL vial for small-scale assays.
- Suitable for analytical and research applications.
- Recommended storage: in solvent -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC 2-Chloro-5-(trifluoromethyl)pyrimidine | 69034-12-4 | 182.53 | 25 G
2-Chloro-5-(trifluoromethyl)pyrimidine is a white to light yellow solid that serves as a drug intermediate for the synthesis of various active compounds. This product is intended for research use only.
- Purity verified by HPLC at 99.84%
- Molecular weight of 182.53
- Chemical formula C5H2ClF3N2
- Appearance as a white to light yellow solid
- Suitable for synthesis of active compounds
- Long-term stability: powder at -20°C for 3 years, or 4°C for 2 years
- Stability in solvent: -80°C for 6 months, or -20°C for 1 month
Medchemexpress LLC Spi-112 | 1051387-90-6 | MFCD31620831 | 98.0% | 468.46 g/mol | C22H17FN4O5S | 1 ML
SPI-112 is a potent, selective, and competitive inhibitor of SHP2 (PTPN11) used for in vitro biochemical and biophysical studies. It inhibits SHP2 with an IC50 of approximately 1 μM, with weaker activity against related phosphatases. Kinetic and binding data indicate competitive inhibition (Ki ≈ 0.8 μM) and 1:1 binding by SPR (KD ≈ 1.3 μM). The compound is not cell permeable and is supplied for research applications.
- Inhibits SHP2 with IC50 ≈ 1 μM.
- Shows selectivity over related phosphatases (IC50s 18.3 μM for PTP, 14.5 μM for PTP1B).
- Exhibits competitive inhibition kinetics (Ki ≈ 0.8 μM).
- Binds 1:1 in SPR with KD ≈ 1.3 μM.
- Not cell permeable due to polar or charged functional groups.
- Supplied as a solid and as a 10 mM solution for in vitro assays.
- High purity suitable for biochemical assays (≈98%).
- Store solid at 4°C; in solvent store at -80°C (long term) or -20°C (short term).