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Filtered Search Results
Medchemexpress LLC BI-2493 | 2937344-16-4 | C24H27N7OS | 50 MG
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BI-2493 is a structural analogue of BI-2865 and a highly selective and orally active pan-KRAS inhibitor. It is designed to attenuate tumor growth and is primarily used for cancer diseases research.
- Highly selective and orally active pan-KRAS inhibitor
- Attenuates tumor growth
- Used for cancer diseases research
- Inhibits proliferation of KRAS mutant cancer cell lines in a concentration-dependent manner
- Exhibits tumor-suppressive activity in xenograft mouse models
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Medchemexpress LLC Givinostat hydrochloride | 199657-29-9 | MFCD28502062 | 98.1% | 457.95 | 100 MG
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Givinostat hydrochloride is a Histone Deacetylase (HDAC) inhibitor that can penetrate the blood-brain barrier (BBB). It is known to inhibit HDAC1 and HDAC3, and has shown efficacy in suppressing inflammatory responses and inhibiting cell proliferation in various studies.
- Inhibits HDAC1 (IC50: 198 nM) and HDAC3 (IC50: 157 nM)
- Penetrates the blood-brain barrier (BBB)
- Suppresses LPS-induced IL-1β production
- Decreases IL-6 secretion in PBMCs
- Inhibits JS-1 cell proliferation
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Apexbio Technology LLC Linagliptin (BI-1356) 668270-12-0 10mg
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Linagliptin (BI-1356 CAS 668270-12-0) is a potent competitive inhibitor of dipeptidyl peptidase-4 (DPP-4) demonstrating IC50 values of 0 4 1 1 nM in multiple in vitro assays using DPP-4 extracted from Caco-2 cells DPP-4 is a membrane-bound and soluble protease involved in the degradation of incretin hormones such as GLP-1 which enhance pancreatic -cell glucose sensitivity and insulin secretion Linagliptin displays marked selectivity for DPP-4 over related peptidases and serine proteases In vivo linagliptin dose-dependently inhibits plasma DPP-4 activity and sustains glycemic control with prolonged effects observed at pharmacologically relevant doses This compound is widely utilized in studies of glucose metabolism and -cell function
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000703596 BI-69A11 5MG
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Medchemexpress LLC Rilmazafone hydrochloride | 85815-37-8 | 511.79 | 100 MG
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Rilmazafone hydrochloride is a benzodiazepine (omega) ligand, intended for research use only.
- Solid storage at 4°C
- Sealed storage, away from moisture
- In solvent storage at -80°C for 6 months
- In solvent storage at -20°C for 1 month
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Medchemexpress LLC Atrasentan hydrochloride | 195733-43-8 | C29H39ClN2O6 | 1 ML
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Atrasentan hydrochloride is a selective endothelin A receptor antagonist, primarily used for research purposes. It has demonstrated significant inhibition of LNCaP and C4-2b prostate cancer cell growth in vitro, with an IC50 of 0.0551 nM for ETA. This compound also impacts drug metabolism by inducing several CYPs and drug transporters.
- Selectively antagonizes endothelin A receptors
- Inhibits LNCaP and C4-2b prostate cancer cell growth
- Induces CYPs and drug transporters
- Acts as a moderate P-gp inhibitor and weak BCRP inhibitor
- Demonstrates in vivo inhibition of pressor response induced by big endothelin-1
- Inhibits C4-2b tumor growth in SCID-hu model
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Accela Chembio Inc 4-bromo-1-naphthoic Acid | 1g | 16650-55-8 | MFCD00094221 | 97+% | Shelf Life: 1260 Days | Light Sensitive/+4
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4-bromo-1-naphthoic Acid | 1g | 16650-55-8 | MFCD00094221 | 97+% | Shelf Life: 1260 Days | Light Sensitive/+4
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AdipoGen NBD-NMe2
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Chemical. CAS 1455-87-4. Formula C8H8N4O3. MW 208.17. Building block and interemediate for organic synthesis. Fluorescent dye. Derivative of the dipolar fluorescent dye NBD. Spectral data lambdaEx=498, lambdaEm=568, Extinction Coefficient=17,000 M-1 cm-1.
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Medchemexpress LLC Acoramidis hydrochloride | 2242751-53-5 | 98.5% | 328.77 | 25 MG
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Acoramidis hydrochloride is an orally active and selective kinetic stabilizer of WT and V122I-TTR (transthyretin). It is used in the study for transthyretin amyloidosis.
- Solid appearance
- Color white to light yellow
- Soluble in DMSO (62.5 mg/mL), insoluble in H2O
- Stabilizes V122I- and WT-TTR
- Stimulates mitochondrial QO2
- Shows minimal inhibition of hERG and cytochrome P450 isozymes
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Medchemexpress LLC Rotigotine Hydrochloride | 125572-93-2 | 99.5% | C19H26ClNOS | 25 MG
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Rotigotine Hydrochloride (N-0923 Hydrochloride) is a potent chemical that functions as a full agonist of dopamine receptors, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor. It exhibits high selectivity for dopamine D3 receptors and is intended for research use only.
- Exhibits Ki values of 0.71 nM for the dopamine D3 receptor.
- Shows Ki values of 4-15 nM for D2, D5, and D4 receptors.
- Has a Ki value of 83 nM for the dopamine D1 receptor.
- Acts as a full agonist at all dopamine receptors.
- Decreases the number of THir neurons by 40% in primary mesencephalic cell culture.
- Protects dopaminergic neurons against MPP+ toxicity and rotenone-induced cell death.
- Inhibits ROS production by rotenone.
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Medchemexpress LLC Ranitidine hydrochloride | 66357-59-3 | 99.9% | 500 MG
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Ranitidine hydrochloride is a potent, selective, and orally active histamine H2-receptor antagonist that inhibits gastric secretion. It has demonstrated efficacy in antagonizing histamine-induced effects in various in vitro models and has also shown activity in inhibiting breast tumor development and spread in mice.
- Potent, selective, and orally active histamine H2-receptor antagonist
- Inhibits gastric secretion
- Antagonizes histamine-induced increases and relaxations in various in vitro models
- Inhibits breast tumor development and spread in mice
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Chemscene CHEMSCENE
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5000579461 2-NAPHTHOL 500G
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Sigma Aldrich Fine Chemicals Biosciences Naphthol AS BI phosphate T5G
Naphthol AS BI phosphate T5G
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Apexbio Technology LLC APEXBIO TECHNOLOGY LLC
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5000568908 BI-2865-1MG
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Ambeed AMBEED
5000848104 6-METHOXY-2-NAPHTHOIC A 1G
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