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Filtered Search Results
eMolecules 135-13-7 | 2-(CARBOXYMETHYLTHIO)BENZOIC ACID | AstaTech | MFCD00021761 | 212.220 | C9H8O4S | 95.000 | OC(=O)CSc1ccccc1C(O)=O | 1g | 722710283
2-(CARBOXYMETHYLTHIO)BENZOIC ACID | AstaTech | 135-13-7 | MFCD00021761 | 212.220 | C9H8O4S | 95.000 | OC(=O)CSc1ccccc1C(O)=O | 1g | 722710283
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eMolecules 352530-43-9 | 2,5-Dichlorophenylzinc iodide, 0.50 M in THF | Synthonix | MFCD02260175 | 338.270 | C6H3Cl2IZn | 0.000 | [I-].Clc1ccc(Cl)c([Zn+])c1 | 25ml | 627353601
2,5-Dichlorophenylzinc iodide, 0.50 M in THF | Synthonix | 352530-43-9 | MFCD02260175 | 338.270 | C6H3Cl2IZn | 0.000 | [I-].Clc1ccc(Cl)c([Zn+])c1 | 25ml | 627353601
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eMolecules 66-71-7 | o-Phenanthroline | ChemScene | MFCD00011678 | 180.210 | C12H8N2 | 98.000 | c1cnc2c(c1)ccc1cccnc21 | 25g | 346751520
o-Phenanthroline | ChemScene | 66-71-7 | MFCD00011678 | 180.210 | C12H8N2 | 98.000 | c1cnc2c(c1)ccc1cccnc21 | 25g | 346751520
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eMolecules 312693-14-4 | 1-Ethylbutylzinc bromide, 0.50 M in THF | Synthonix230.450 | C6H13BrZn | 0.000 | [Br-].CCCC([Zn+])CC | 50ml | 532652797
1-Ethylbutylzinc bromide, 0.50 M in THF | Synthonix | 312693-14-4230.450 | C6H13BrZn | 0.000 | [Br-].CCCC([Zn+])CC | 50ml | 532652797
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Medchemexpress LLC 2-(naphthalen-2-yl)acetonitrile | 7498-57-9 | MFCD00004122 | 100.0% | 167.21 g/mol | C12H9N | 500 G
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2-(Naphthalen-2-yl)acetonitrile is a chemical intermediate used in the synthesis of active pharmaceutical compounds and research-stage derivatives. It has molecular formula C12H9N and a molecular weight of 167.21 g/mol. The product is supplied in laboratory and bulk pack sizes and is accompanied by a product datasheet and safety data sheet for research use only.
- Drug intermediate for synthesis of active pharmaceutical compounds.
- Molecular formula C12H9N; molecular weight 167.21 g/mol.
- High reported purity (99.96%).
- Available in laboratory and bulk pack sizes, including 500 g.
- Supplied with accompanying datasheet and safety data sheet.
- Intended for research use; not for human or veterinary use.
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eMolecules 131554-33-1 | 2-Benzothiazolylmagnesium bromide, 0.50 M in THF | Synthonix238.390 | C7H4BrMgNS | 0.000 | [Br-].[Mg+]c1nc2ccccc2s1 | 50ml | 702445851
2-Benzothiazolylmagnesium bromide, 0.50 M in THF | Synthonix | 131554-33-1238.390 | C7H4BrMgNS | 0.000 | [Br-].[Mg+]c1nc2ccccc2s1 | 50ml | 702445851
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Medchemexpress LLC BI-3231 | 2894848-07-6 | 99.8% | 380.37 | 50 MG
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BI-3231 is a potent and selective chemical probe that inhibits hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), with IC50 values of 1 nM for hHSD17B13 and 13 nM for mHSD17B13. It is being researched for its potential in treating nonalcoholic steatohepatitis (NASH) and other liver diseases.
- Potent and selective hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) inhibitor
- Demonstrates high metabolic stability in liver microsomes
- Moderate metabolic stability in hepatocytes
- Significant hepatic exposure maintained over 48 hours
- Potential for research into nonalcoholic steatohepatitis (NASH) and other liver diseases
- Powder storage: -20°C for 3 years
- In solvent storage: -80°C for 6 months, -20°C for 1 month
- Solubility in DMSO: 125 mg/mL (328.63 mM)
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eMolecules 131379-16-3 | 4-(Ethoxycarbonyl)phenylzinc iodide, 0.50 M in THF | Synthonix | MFCD00671982 | 341.450 | C9H9IO2Zn | 0.000 | [I-].CCOC(=O)c1ccc([Zn+])cc1 | 100ml | 532652818
4-(Ethoxycarbonyl)phenylzinc iodide, 0.50 M in THF | Synthonix | 131379-16-3 | MFCD00671982 | 341.450 | C9H9IO2Zn | 0.000 | [I-].CCOC(=O)c1ccc([Zn+])cc1 | 100ml | 532652818
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Medchemexpress LLC BLU-945 | 2660250-10-0 | 99.4% | C28H37FN6O3S | 100 MG
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BLU-945 is a potent, highly selective, reversible, and orally active epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI). It effectively inhibits EGFR with L858R and/or exon 19 deletion mutation, T790M mutation, and C797S mutation, making it suitable for research into lung cancer, including non-small cell lung cancer (NSCLC).
- Potent, highly selective, reversible, and orally active EGFR tyrosine kinase inhibitor.
- Effectively inhibits EGFR with L858R and/or exon 19 deletion mutation, T790M mutation, and C797S mutation.
- Used for research of lung cancer, including non-small cell lung cancer (NSCLC).
- Exhibits inhibitory activity against EGFRm/T790M double and EGFRm/T790M/C797S triple mutants.
- Demonstrates potent, robust EGFR pathway inhibition and anti-tumor activity in Osimertinib-resistant models.
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eMolecules 111762-30-2 | 5-Chloro-2-thienylmagnesium bromide, 0.50 M in THF | Synthonix | MFCD02260211 | 221.780 | C4H2BrClMgS | 0.000 | [Br-].[Mg+]c1ccc(Cl)s1 | 100ml | 702445873
5-Chloro-2-thienylmagnesium bromide, 0.50 M in THF | Synthonix | 111762-30-2 | MFCD02260211 | 221.780 | C4H2BrClMgS | 0.000 | [Br-].[Mg+]c1ccc(Cl)s1 | 100ml | 702445873
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Medchemexpress LLC Etilefrine hydrochloride | 943-17-9 | 99.9% | C10H16ClNO2 | 100 MG
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Etilefrine hydrochloride is a sympathetic nerve agonist and AMPK activator that selectively targets α1/β1 adrenergic receptors. It stimulates α1 adrenergic receptors, leading to contraction of vascular smooth muscle and increased peripheral resistance. It also stimulates β1 receptors to enhance myocardial contractility and increase heart rate, thereby increasing blood pressure and improving cardiac output. Etilefrine hydrochloride also bidirectionally regulates the AMPK/Akt pathway and modulates the phosphorylation levels.
- Sympathetic nerve agonist and AMPK activator
- Selectively targets α1/β1 adrenergic receptors
- Increases blood pressure and improves cardiac output
- Bidirectionally regulates the AMPK/Akt pathway
- Applicable in cardiovascular research for conditions like postural hypotension, chylothorax, and improving low cardiac output
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Medchemexpress LLC Ganfeborole hydrochloride | 2131798-13-3 | 293.94 g/mol | C10H14BCl2NO4 | 25 MG
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Ganfeborole hydrochloride is a research-grade antitubercular small molecule that inhibits Mycobacterium tuberculosis leucyl-tRNA synthetase (LeuRS) and is supplied as the hydrochloride salt for laboratory research.
- Inhibits Mycobacterium tuberculosis leucyl-tRNA synthetase (IC50 ≈ 0.2 μM).
- Supplied as a hydrochloride salt to facilitate handling and solubility.
- Molecular weight 293.94 g/mol (hydrochloride).
- Used for antitubercular research and preclinical studies.
- Provided with safety and handling information in an SDS.
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Medchemexpress LLC BI-4020 | 2664214-60-0 | 99.3% | 25 MG
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BI-4020 is a fourth-generation, orally active, and non-covalent EGFR tyrosine kinase inhibitor. It inhibits the triple mutant EGFR del19 T790M C797S variant with an IC50 of 0.2 nM in BaF3 cell lines, as well as the double mutant EGFR del19 T790M and primary mutant EGFR del19 (IC50=1 nM). This inhibitor also shows activity against EGFR wt (IC50=190 nM) and exhibits high kinome selectivity and good DMPK properties. It is for research use only.
- Fourth-generation, orally active, and non-covalent EGFR tyrosine kinase inhibitor
- Inhibits triple mutant EGFR del19 T790M C797S variant with an IC50 of 0.2 nM
- Inhibits double mutant EGFR del19 T790M and primary mutant EGFR del19 with an IC50 of 1 nM
- Shows activity against EGFR wt (IC50 = 190 nM)
- Exhibits high kinome selectivity and good DMPK properties
- Intended for research use only
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Medchemexpress LLC [1,1'-Biphenyl]-3-propanoic acid, a-amino-2'-chloro-5-(phosphonomethyl)-, (aS)- | 174575-17-8 | 98.8% | 25 MG
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SDZ 220-581 is an orally active, potent, competitive NMDA receptor antagonist with a pKi value of 7.7. It has been shown to dose-dependently protect mice against maximal electroshock seizures (MES) upon oral administration, with a rapid onset and long duration of action.
- Potent, competitive NMDA receptor antagonist
- Orally active
- Demonstrated pKi value of 7.7
- Protects against maximal electroshock seizures (MES) in vivo
- Offers rapid onset of action
- Provides long duration of action
- High purity of 98.76%
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eMolecules 117973-14-5 | 3-(tert-Butyldimethylsiloxy)phenylmagnesium bromide, 0.50 M in THF | Synthonix311.577 | C12H19BrMgOSi | 0.000 | [Br-].CC(C)(C)[Si](C)(C)Oc1cccc([Mg+])c1 | 50ml | 761751056
3-(tert-Butyldimethylsiloxy)phenylmagnesium bromide, 0.50 M in THF | Synthonix | 117973-14-5311.577 | C12H19BrMgOSi | 0.000 | [Br-].CC(C)(C)[Si](C)(C)Oc1cccc([Mg+])c1 | 50ml | 761751056
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