Naphthalenes

eMolecules​ ChemScene o-Phenanthroline 25g 346751520 CS-W004544 66-71-7 MFCD00011678 180.210 C12H8N2

ChemScene o-Phenanthroline 25g 346751520 CS-W004544 66-71-7 MFCD00011678 180.210 C12H8N2

Medchemexpress LLC [(3,5-bis(trifluoromethyl)phenyl)methyl] azabicyclohexane carboxylate | 2162961-71-7 | >98.0% | 527.4 g/mol | C23H19F6N5O3 | 10MM 1ML

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BI-2545 is a potent small-molecule autotaxin (ATX) inhibitor used as a preclinical chemical probe to reduce lysophosphatidic acid (LPA) levels in vitro and in vivo. It exhibits single-digit nanomolar enzyme potency and measurable whole-blood activity; supplied for research use as a solid or concentrated solution. CAS: 2162961-71-7. Chemical formula: C23H19F6N5O3.

• Potent ATX inhibition in enzyme assays (human ATX IC50 2.2 nM; rat ATX IC50 3.4 nM).
• Demonstrated whole-blood activity (human IC50 29 nM; rat IC50 96 nM).
• Suitable for in vitro and in vivo preclinical studies.
• High purity suitable for research (>98.0%).
• Molecular weight 527.4 g/mol; chemical formula C23H19F6N5O3.
• Available as solid or concentrated solution for dosing flexibility.

AdipoGen trans-Indole-3-acrylic acid

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Chemical. CAS 29953-71-7. Formula C11H9NO2. MW 187.2. Synthetic. Inflammation suppressor. Tryptophan metabolite produced by human microbiota intestinal commensale Peptostreptococcus sp. Involved in keeping the intestinal barrier intact and works as anti-inflammatory molecule. Patients with Inflammatory bowel Disease IBD have an altered microbiota, with less Peptostreptococcus sp., and therefore reduced production of trans-indole-3-acrylic acid. Chromophoric L-Trp analog used to probe the allosteric properties of the internal aldimine of tryptophan synthas. Also shown to be a moderate inhibitor of tryptophan synthase, trypothan-2,3-dioxygenase, indoleamine-2,3-dioxygenase, L-dopachrome isomerase and xanthine oxidase. Reagent used as a matrix for MALDI-TOF mass spectroscopy in order to characterize and analyze polyphenols and synthetic polymers.

AdipoGen trans-Indole-3-acrylic acid

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Chemical. CAS 29953-71-7. Formula C11H9NO2. MW 187.2. Synthetic. Inflammation suppressor. Tryptophan metabolite produced by human microbiota intestinal commensale Peptostreptococcus sp. Involved in keeping the intestinal barrier intact and works as anti-inflammatory molecule. Patients with Inflammatory bowel Disease IBD have an altered microbiota, with less Peptostreptococcus sp., and therefore reduced production of trans-indole-3-acrylic acid. Chromophoric L-Trp analog used to probe the allosteric properties of the internal aldimine of tryptophan synthas. Also shown to be a moderate inhibitor of tryptophan synthase, trypothan-2,3-dioxygenase, indoleamine-2,3-dioxygenase, L-dopachrome isomerase and xanthine oxidase. Reagent used as a matrix for MALDI-TOF mass spectroscopy in order to characterize and analyze polyphenols and synthetic polymers.