Naphthalenes

Medchemexpress LLC JNJ28871063 hydrochloride | 944342-90-9 | 98.4% | 519.42 | C24H28Cl2N6O3 | 25 MG

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Small and/or specialty supplier based on Federal laws and SBA requirements.
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JNJ28871063 hydrochloride (CAS 944342-90-9) is an orally active, ATP-competitive pan-ErbB kinase inhibitor used in research to probe EGFR/ErbB2/ErbB4 signaling and oncology models. It inhibits phosphorylation of key tyrosine residues, crosses the blood-brain barrier, and shows antitumor activity in xenograft studies.

• Potent pan-ErbB inhibition with reported IC50 values of ~22 nM (EGFR), 38 nM (ErbB2), and 21 nM (ErbB4).
• ATP-competitive mechanism of action.
• Demonstrated antitumor activity in human tumor xenograft models.
• Crosses the blood-brain barrier, enabling central nervous system studies.
• Provided as the hydrochloride salt; molecular weight 519.42 and formula C24H28Cl2N6O3.
• High purity (~98.4% by HPLC), suitable for in vitro and in vivo research.

Medchemexpress LLC Jnj28871063 hydrochloride | 944342-90-9 | 98.4% | 519.42 | C24H28Cl2N6O3 | 100 MG

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More

JNJ28871063 hydrochloride is an ATP-competitive pan-ErbB (EGFR/ErbB) kinase inhibitor used for research. It is orally active, shows potent inhibition of ErbB family kinases, crosses the blood-brain barrier, and has demonstrated antitumor activity in xenograft models.

• Orally active, ATP-competitive pan-ErbB kinase inhibitor.
• Potent inhibition of EGFR (ErbB1), ErbB2, and ErbB4 (IC50 ≈ 21-38 nM).
• Crosses the blood-brain barrier.
• Demonstrated antitumor activity in EGFR/ErbB2-overexpressing xenograft models.
• Supplied as the hydrochloride salt.
• Intended for in vitro and in vivo research use only.

Sigma Aldrich Fine Chemicals Biosciences Dansylhydrazine BioReagent, suitable for fluorescence, >=90% (HPLC) | 33008-06-9 | MFCD00003986 | 1G

Dansylhydrazine BioReagent, suitable for fluorescence, >=90% (HPLC) | Purity: >=90% (HPLC) | Mol Wt: 265.33 | 33008-06-9 | MFCD00003986 | 1G

Sigma Aldrich Fine Chemicals Biosciences Dansylhydrazine BioReagent, suitable for fluorescence, >=90% (HPLC) | 33008-06-9 | MFCD00003986 | 250MG

Dansylhydrazine BioReagent, suitable for fluorescence, >=90% (HPLC) | Purity: >=90% (HPLC) | Mol Wt: 265.33 | 33008-06-9 | MFCD00003986 | 250MG

Sigma Aldrich Fine Chemicals Biosciences Dansylhydrazine BioReagent, suitable for fluorescence, >=90% (HPLC) | 33008-06-9 | MFCD00003986 | 5G

Dansylhydrazine BioReagent, suitable for fluorescence, >=90% (HPLC) | Purity: >=90% (HPLC) | Mol Wt: 265.33 | 33008-06-9 | MFCD00003986 | 5G