Phenanthrenes and derivatives
Medchemexpress LLC Sch-1473759 hydrochloride | 1094067-13-6 | MFCD18251447 | 99.2% | 463.00 g/mol | C20H27ClN8OS | 200 MG
SCH-1473759 hydrochloride is a small-molecule dual aurora kinase inhibitor used in research to probe cell-cycle regulation and kinase signaling. It potently inhibits Aurora A and Aurora B at low nanomolar concentrations and displays activity against several related kinases.
- Potent dual Aurora A and B inhibition (IC50 = 4 nM and 13 nM).
- Direct binding to Aurora kinases (Kd ≈ 20-30 nM).
- Additional kinase activity including VEGFR2, Src family, Chk1, and IRAK4.
- High purity (≈99.2%) and solid, white to yellow physical form.
- Soluble in DMSO and water with warming; reported in vivo formulation options available.
- Suitable for cell-cycle and kinase signaling research applications.
- Recommended sealed storage; in solvent long-term storage at -80°C.
Apexbio Technology LLC Sinapinic acid 530-59-6 200mg
Sinapinic acid (CAS 530-59-6) is an organic compound commonly utilized as a matrix in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry where it facilitates the desorption and ionization of proteins and peptides for accurate molecular weight determination The compound s ability to absorb laser energy and promote analyte ionization underpins its effectiveness in proteomics research Additionally sinapinic acid is naturally occurring in propolis contributing to the compound s significance in natural product studies Its primary research applications center on biomolecular analysis and the characterization of protein mixtures
Medchemexpress LLC Azelastine hydrochloride | 79307-93-0 | 99.9% | 200 MG
Azelastine hydrochloride is an antihistamine that acts as a potent and selective histamine 1 (H1) antagonist. It is suitable for research related to allergic rhinitis, asthma, diabetic hyperlipidemia, and SARS-CoV-2. This product is for research use only.
- Potent and selective histamine 1 (H1) antagonist.
- Inhibits HNEpC proliferation, potentially aiding in airway remodeling.
- Upregulates H1R, M1R, and M3R levels in human nasal epithelial cells.
- In diabetic hyperlipidemic rat models, it significantly reduces blood glucose, HbA1c, serum alkaline phosphatase, and osteocalcin.
- Downregulates apolipoprotein B.
- Improves lipid profile (decreasing LDL-c and increasing HDL-c).
- Attenuates calcium deposition and aortic calcification.
eMolecules 141-82-2 | Malonic acid | Key Organics/BIONET104.061 | C3H4O4 | 95.000 | OC(=O)CC(O)=O | 1mg | 564178357
Malonic acid | Key Organics/BIONET | 141-82-2104.061 | C3H4O4 | 95.000 | OC(=O)CC(O)=O | 1mg | 564178357
Medchemexpress LLC AM095 free acid | 1228690-36-5 | 99.0% | 456.49 | 200 MG
AM095 free acid is a potent LPA1 receptor antagonist that effectively inhibits LPA-induced calcium flux in CHO cells transfected with human or mouse LPA1. It also significantly reduces LPA-induced vasorelaxation and inhibits LPA-driven chemotaxis in various cell types. In preclinical studies, it has shown to attenuate bleomycin-induced dermal fibrosis and decrease kidney fibrosis in a mouse model of unilateral ureteral obstruction. The compound exhibits high oral bioavailability, a moderate half-life, and is well tolerated in animal models.
- Potent LPA1 receptor antagonist.
- Inhibits LPA-induced calcium flux in CHO cells.
- Reduces LPA-induced vasorelaxation.
- Inhibits LPA-driven chemotaxis in melanoma cells.
- Attenuates bleomycin-induced dermal fibrosis in vivo.
- Decreases kidney fibrosis in a mouse model.
- High oral bioavailability.
- Moderate half-life.
- Well tolerated in rats and dogs.
Apexbio Technology LLC D-3-Phenyllactic acid 7326-19-4 200mg
D-3-Phenyllactic acid (CAS 7326-19-4) is a small-molecule inhibitor targeting specific Gram-positive and Gram-negative bacterial strains It is designed to disrupt microbial cell membrane integrity and interfere with related cellular metabolic pathways thereby inhibiting bacterial growth D-3-Phenyllactic acid exerts its biological activity primarily through disruption of microbial membranes and interference with cellular metabolism In in vitro studies D-3-Phenyllactic acid demonstrates inhibitory activity with reported IC50 values typically ranging between 10 50 g/mL depending on the target microorganism Based on these pharmacological properties D-3-Phenyllactic acid holds research potential in applications related to pathogen control in food safety and human health
Apexbio Technology LLC CVT-313 199986-75-9 200mg
CVT-313 (CAS 199986-75-9) is a potent inhibitor of cyclin-dependent kinase 2 (CDK2) an enzyme essential for G1/S transition during cell cycle progression By targeting CDK2 CVT-313 effectively reduces hyperphosphorylation of retinoblastoma protein (Rb) leading to cell cycle arrest at the G1/S boundary In vitro studies with MRC-5 fibroblasts demonstrated significant growth inhibition Additionally CVT-313 induces apoptosis in diffuse large B-cell lymphoma by diminishing phosphorylation of Rb at T821 and downregulating anti-apoptotic protein Mcl-1 In animal models of arterial restenosis CVT-313 significantly reduces neointimal proliferation indicating potential utility for proliferative disorders research
Medchemexpress LLC Ivabradine hydrochloride | 148849-67-6 | 99.71% | 200 MG
Ivabradine hydrochloride is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). It reduces heart rate in a dose-dependent manner without affecting blood pressure.
- Potent and orally active HCN channel blocker.
- Inhibits cardiac pacemaker current (If).
- Reduces heart rate dose-dependently without modifying blood pressure.
- Exhibits anticonvulsant, anti-ischaemic, and anti-anginal activity.
- Attenuates PTZ- and PICRO-induced seizures.
- Exhibits antioxidant effects in brain areas.
- Reduces cleaved caspase-3 expression.
Apexbio Technology LLC CHELIDAMIC-ACID-200MG
Chelidamic acid (CAS No 138-60-3) is a compound explored within the biomedical research category for its potential therapeutic applications Originating from studies focused on derivative analogs of known bioactive molecules it primarily targets enzymatic pathways involved in inflammatory and oxidative processes Its mechanism of action involves modulating key biochemical pathways which could influence cellular responses to stress and damage Demonstrating in vitro activity generally in the nanomolar to low micromolar range Chelidamic acid is frequently utilized in cell models and animal studies to assess its efficacy and safety profile These evaluations are critical in drug screening processes to identify potential therapeutic agents Experimental concentrations typically depend on the specific research design making it a versatile option for a wide array of scientific inquiries
Aobchem Triphenylene-2-carboxylic acid | ≥97% | CAS 109534-58-9 | C19H12O2 | 1g
Triphenylene-2-carboxylic acid | ≥97% | CAS 109534-58-9 | C19H12O2 | 1g