Acrylic acids and derivatives
Medchemexpress LLC Calcium disodium EDTA dihydrate | 6766-87-6 | 99.9% | 410.0226 Da | C10H16CaN2Na2O10 | 10g
Ca -EDTA disodium dihydrate (Calcium disodium EDTA dihydrate) is an orally active metal chelating reagent exhibits bactericidal activities against periodontal pathogens Aggregatibacter actinomycetemcomitans Prevotella intermedia and Porphyromonas gingivalis[1] Ca -EDTA disodium dihydrate is effective chelating antidotes for lead-and cadmium poisoning[2][3]
Apexbio Technology LLC KW-2478 819812-04-9 100mg
KW-2478 (CAS 819812-04-9) is a potent non-ansamycin inhibitor of heat shock protein 90 (Hsp90) Unlike traditional Hsp90 inhibitors such as 17-AAG KW-2478 exhibits improved aqueous solubility and reduced hepatotoxicity In multiple myeloma cell models KW-2478 induces degradation of Hsp90 client proteins and leads to downregulation of IgH translocation products including FGFR3 c-Maf and cyclin D1 thereby inhibiting cell proliferation and promoting apoptosis Additionally KW-2478 reduces levels of Cdk9 and phosphorylated 4E-BP1 further suppressing oncogenic transcriptional regulators This compound is a valuable tool for studying Hsp90-mediated pathways and evaluating therapeutic strategies in hematological malignancies
Apexbio Technology LLC KW-2478 819812-04-9 5mg
KW-2478 (CAS 819812-04-9) is a potent non-ansamycin inhibitor of heat shock protein 90 (Hsp90) Unlike traditional Hsp90 inhibitors such as 17-AAG KW-2478 exhibits improved aqueous solubility and reduced hepatotoxicity In multiple myeloma cell models KW-2478 induces degradation of Hsp90 client proteins and leads to downregulation of IgH translocation products including FGFR3 c-Maf and cyclin D1 thereby inhibiting cell proliferation and promoting apoptosis Additionally KW-2478 reduces levels of Cdk9 and phosphorylated 4E-BP1 further suppressing oncogenic transcriptional regulators This compound is a valuable tool for studying Hsp90-mediated pathways and evaluating therapeutic strategies in hematological malignancies
Apexbio Technology LLC KW-2478 819812-04-9 10mg
KW-2478 (CAS 819812-04-9) is a potent non-ansamycin inhibitor of heat shock protein 90 (Hsp90) Unlike traditional Hsp90 inhibitors such as 17-AAG KW-2478 exhibits improved aqueous solubility and reduced hepatotoxicity In multiple myeloma cell models KW-2478 induces degradation of Hsp90 client proteins and leads to downregulation of IgH translocation products including FGFR3 c-Maf and cyclin D1 thereby inhibiting cell proliferation and promoting apoptosis Additionally KW-2478 reduces levels of Cdk9 and phosphorylated 4E-BP1 further suppressing oncogenic transcriptional regulators This compound is a valuable tool for studying Hsp90-mediated pathways and evaluating therapeutic strategies in hematological malignancies
Apexbio Technology LLC KW-2478 819812-04-9 50mg
KW-2478 (CAS 819812-04-9) is a potent non-ansamycin inhibitor of heat shock protein 90 (Hsp90) Unlike traditional Hsp90 inhibitors such as 17-AAG KW-2478 exhibits improved aqueous solubility and reduced hepatotoxicity In multiple myeloma cell models KW-2478 induces degradation of Hsp90 client proteins and leads to downregulation of IgH translocation products including FGFR3 c-Maf and cyclin D1 thereby inhibiting cell proliferation and promoting apoptosis Additionally KW-2478 reduces levels of Cdk9 and phosphorylated 4E-BP1 further suppressing oncogenic transcriptional regulators This compound is a valuable tool for studying Hsp90-mediated pathways and evaluating therapeutic strategies in hematological malignancies
Medchemexpress LLC Elaiophylin | 37318-06-2 | C54H88O18 | 5 MG
Elaiophylin is an autophagy inhibitor that exhibits antitumor activity in ovarian cancer cells. With a molecular weight of 1025.27, it appears as a white to off-white solid and is intended for research use only.
- Autophagy inhibitor
- Exhibits antitumor activity in ovarian cancer cells
- Molecular weight of 1025.27
- White to off-white solid appearance
- Soluble in DMSO for in vitro experiments
- Affects ovarian cancer cell survival during hypoxia
- Leads to activation of cleaved CASP9/caspase-9 and PARP1
- Downregulates BIRC5/survivin
- Suppresses ovarian cancer SKOV3 cell growth in athymic mice
- Achieves significant antitumor effects without toxicity at lower doses