Alpha-halocarboxylic acids and derivatives
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Filtered Search Results
AdipoGen Naphthol AS-D chloroacetate
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Chemical. CAS 35245-26-2. Formula C20H16ClNO3. MW BD9837. Naphthol AS-D chloroacetate NASDCA is a fluorigenic substrate for granulocyte specific esterases e.g. Proteinase 3 PR3 and Cathepsin G. It can be hydrolyzed into Naphthol AS-D by esterases to mix with diazonium salt and form insoluble red-brown precipitate in the cytoplasm that can be visualized under a microscope. This enzyme is usually considered specific for cells of granulocytic lineage. NASDCA can be used for the visualisation of cells in formalin-fixed or paraffin-embedded tissue in a substrate solution for naphthol-AS-D-chloroacetate-esterase CIAE staining. Proteinase 3 P3R is a serine protease that is found in neutrophils and a subpopulation of monocytes. It is the most specific enzyme for NASDCA hydrolysis, and it is used in a variety of diagnostic tests to detect granulocytes. Cathepsin G is another serine protease that is found in neutrophils.
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AdipoGen GE23077 A1 B1
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Chemical. CAS 752989-46-1, 752989-45-0752989-44-9. Formula C31H51N9O16, C31H49N9O16. MW 805.8803.8. Isolated from Actinomadura sp. Cyclic heptapeptide antibiotic. Potent and selective inhibitor of bacterial RNA polymerase RNAP. Inhibits Gram-positive Bacillus subtilis and Gram-negative Escherichia coli RNAPs with IC50 ~20nM, whereas it is not active on E. coli DNA polymerase or on eukaryotic wheat germ RNAP II IC50 values >100µM. Even though of its potent activity in vitro on purified bacterial RNAPs, it shows a narrow spectrum of antimicrobial activity in vivo on Gram-positive and Gram-negative bacteria, due to lack of memmbrane permeability. Acts at the level of transcription initiation. Binds directly to the bacterial RNA polymerase RNAP active-center i and i1 nucleotide binding sites, preventing the binding of initiating nucleotides and thereby preventing transcription initiation.
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eMolecules EMOLECULES INC
5000483233 BROMOACETIC ACID N-HYDROXY 25G
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AdipoGen Rhodamine 6G p-DAX amide bis
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Chemical. CAS 591742-78-8. Formula C34H36N4O2 . C4H2F6O4. MW 760.72. Synthetic. Fluorescent labelling.
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AdipoGen Rhodamine 6G bis OEAE amide
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Chemical. CAS 1173097-69-2. Formula C32H40N4O4 . C4H2F6O4. MW 772.73. Synthetic. Fluorescent labelling.
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AdipoGen Rhodamine 6G p-DAX amide bis
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Chemical. CAS 591742-78-8. Formula C34H36N4O2 . C4H2F6O4. MW 760.72. Synthetic. Fluorescent labelling.
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Cayman Chemical SHU9119 trifluoroacetate sal
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An MC1R agonist and MC4R antagonist (IC50s = 1.2 and 2.9 nM, respectively, for displacement of melanocortin); induces cAMP formation in HEK293 cells expressing human MC1R (EC50 = 1.11 nM), but inhibits cAMP formation in cells expressing human MC4R; increases food intake, body weight, fat mass, and lean mass, with concomitant increases in blood glucose, insulin, and leptin levels via disrupted melanocortin signaling in rats (24 nmol, i.c.v. per day for seven days); increases in body weight and fat mass in mice
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Cayman Chemical Pentosidine trifluoroacetate
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A well-characterized natural advanced glycation end (AGE) that is often used as a biomarker for the production of all AGEs
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Cayman Chemical W140 trifluoroacetate salt
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An inactive enantiomer of W146; binds weakly to S1P1 (Ki = 4.6 µM for the human receptor); has been used as a negative control in the study of S1P1 receptor signaling
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eMolecules DIFLUOROACETIC ANHYDRIDE 5G
5000224589 DIFLUOROACETIC ANHYDRIDE 5G
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Sigma Aldrich Fine Chemicals Biosciences Bromoacetic acid-2-13C 99 atom % 13C | 64891-77-6 | MFCD00002681 | 1G
Bromoacetic acid-2-13C 99 atom % 13C | Purity: 99% (CP) | Mol Wt: 139.94 | 64891-77-6 | MFCD00002681 | 1G
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Cayman Chemical FTI276 trifluoroacetate salt
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A peptidomimetic inhibitor of FTase (IC50 = 500 pM); selective for FTase over GGTase I (IC50 = 50 nM); inhibits the growth of NIH3T3 cells expressing RasF at 20 µM; reduces tumor growth in a mouse xenograft model using Calu-1 cells that contain a K-Ras oncogenic mutation
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Selleck Chemical LLC RR82 Trifluoroacetate Salt
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Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay which targets a series of proto-oncogenes
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eMolecules BROMOACETIC ACID N-HYDROXYS 1G
5000224219 BROMOACETIC ACID N-HYDROXYS 1G
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Sigma Aldrich Fine Chemicals Biosciences Ethyl bromoacetate-2-13C 99 atom % 13C | 85539-84-0 | MFCD00000193 | 250MG
Ethyl bromoacetate-2-13C 99 atom % 13C | Purity: 99% (CP) | Mol Wt: 167.99 | 85539-84-0 | MFCD00000193 | 250MG
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