Alpha-halocarboxylic acids and derivatives
Selleck Chemical LLC RR82 Trifluoroacetate Salt
Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay which targets a series of proto-oncogenes
Sigma Aldrich Fine Chemicals Biosciences Sodium chloroacetate | 3926-62-3 | MFCD00002684 | 1kg
Sodium chloroacetate | Purity: 98% | MW:116.48 | 3926-62-3 | MFCD00002684 | 1kg
Sigma Aldrich Fine Chemicals Biosciences Sodium chloroacetate | 3926-62-3 | MFCD00002684 | 25g
Sodium chloroacetate | Purity: 98% | MW:116.48 | 3926-62-3 | MFCD00002684 | 25g
Sigma Aldrich Fine Chemicals Biosciences Ethyl 2-bromopropionate 99% | 535-11-5 | MFCD00000144 | 100G
Ethyl 2-bromopropionate 99% | Purity: 99% | Mol Wt: 181.03 | 535-11-5 | MFCD00000144 | 100G
Sigma Aldrich Fine Chemicals Biosciences Benzyl bromoacetate 96% | 5437-45-6 | MFCD00000190 | 250G
Benzyl bromoacetate 96% | Purity: 96% | Mol Wt: 229.07 | 5437-45-6 | MFCD00000190 | 250G
Sigma Aldrich Fine Chemicals Biosciences Ethyl 2-bromopropionate 99% | 535-11-5 | MFCD00000144 | 25G
Ethyl 2-bromopropionate 99% | Purity: 99% | Mol Wt: 181.03 | 535-11-5 | MFCD00000144 | 25G
Sigma Aldrich Fine Chemicals Biosciences Ethyl 2-chloropropionate 97% | 535-13-7 | MFCD00000864 | 25ML
Ethyl 2-chloropropionate 97% | Purity: 97% | Mol Wt: 136.58 | 535-13-7 | MFCD00000864 | 25ML
Sigma Aldrich Fine Chemicals Biosciences Sodium iodoacetate BioUltra, >=98% | 305-53-3 | MFCD00002686 | 5G
Sodium iodoacetate BioUltra, >=98% | Purity: >=98% | Mol Wt: 207.93 | 305-53-3 | MFCD00002686 | 5G
Sigma Aldrich Fine Chemicals Biosciences Ethyl chloroacetate 99% | 105-39-5 | MFCD00000932 | 1L
Ethyl chloroacetate 99% | Purity: 99% | Mol Wt: 122.55 | 105-39-5 | MFCD00000932 | 1L
Sigma Aldrich Fine Chemicals Biosciences Chloroacetic acid-d3 98 atom % D | 1796-85-6 | MFCD00143952 | 5G
Chloroacetic acid-d3 98 atom % D | Purity: 99% (CP) | Mol Wt: 97.52 | 1796-85-6 | MFCD00143952 | 5G
eMolecules Ambeed / Ethyl 2-bromopropionate / 25g / 602851890 / A344349 / / 535-11-5 / MFCD00000144 / 181.029 / C5H9BrO2
Ambeed / Ethyl 2-bromopropionate / 25g / 602851890 / A344349 / / 535-11-5 / MFCD00000144 / 181.029 / C5H9BrO2
AdipoGen Rhodamine 6G bis AEA amide bis
Chemical. CAS 1173097-37-4. Formula C30H37N5O2 . C4H2F6O4. MW 727.69. Synthetic. Fluorescent labelling.
AdipoGen Naphthol AS-D chloroacetate
Chemical. CAS 35245-26-2. Formula C20H16ClNO3. MW BD9837. Naphthol AS-D chloroacetate NASDCA is a fluorigenic substrate for granulocyte specific esterases e.g. Proteinase 3 PR3 and Cathepsin G. It can be hydrolyzed into Naphthol AS-D by esterases to mix with diazonium salt and form insoluble red-brown precipitate in the cytoplasm that can be visualized under a microscope. This enzyme is usually considered specific for cells of granulocytic lineage. NASDCA can be used for the visualisation of cells in formalin-fixed or paraffin-embedded tissue in a substrate solution for naphthol-AS-D-chloroacetate-esterase CIAE staining. Proteinase 3 P3R is a serine protease that is found in neutrophils and a subpopulation of monocytes. It is the most specific enzyme for NASDCA hydrolysis, and it is used in a variety of diagnostic tests to detect granulocytes. Cathepsin G is another serine protease that is found in neutrophils.
AdipoGen Bafilomycin B1
Chemical. CAS 88899-56-3. Formula C44H65NO13. MW 815.9. Isolated from Streptomyces hygroscopicus. Macrolide antibiotic. Specific vacuolar-type H-ATPase inhibitor. Inhibitor of autophagic degradation by rising lysosomal pH and thus inactivating the lysosomal acid hydrolases. Antitrypanosomal and antileishmanial compound. Phytotoxic. Influences the cell wall biosynthesis of Asp. niger.
AdipoGen GE23077 A1 B1
Chemical. CAS 752989-46-1, 752989-45-0752989-44-9. Formula C31H51N9O16, C31H49N9O16. MW 805.8803.8. Isolated from Actinomadura sp. Cyclic heptapeptide antibiotic. Potent and selective inhibitor of bacterial RNA polymerase RNAP. Inhibits Gram-positive Bacillus subtilis and Gram-negative Escherichia coli RNAPs with IC50 ~20nM, whereas it is not active on E. coli DNA polymerase or on eukaryotic wheat germ RNAP II IC50 values >100µM. Even though of its potent activity in vitro on purified bacterial RNAPs, it shows a narrow spectrum of antimicrobial activity in vivo on Gram-positive and Gram-negative bacteria, due to lack of memmbrane permeability. Acts at the level of transcription initiation. Binds directly to the bacterial RNA polymerase RNAP active-center i and i1 nucleotide binding sites, preventing the binding of initiating nucleotides and thereby preventing transcription initiation.