Organic phosphoric acids and derivatives
Apexbio Technology LLC KN-93 Phosphate 1188890-41-6 1mg
KN-93 Phosphate (CAS 1188890-41-6) is a small-molecule inhibitor targeting calcium/calmodulin-dependent protein kinase II (CaMKII) It is designed to selectively inhibit CaMKII thereby modulating cellular proliferation survival neurotransmitter regulation and related signal transduction pathways KN-93 Phosphate exerts its biological activity primarily by competitively binding to Ca2 /calmodulin disrupting their interaction with CaMKII and preventing CaMKII activation and autophosphorylation In cell-based studies KN-93 Phosphate demonstrates inhibitory activity with IC50 values of 9 M for CaMKII monomer and 3 M for CaMKII dodecamer Experimental models include hepatic stellate cells and NIH 3T3 fibroblasts Based on these pharmacological properties KN-93 Phosphate holds research potential in the study of cell cycle regulation apoptosis neurotransmitter synthesis and neurodegenerative disorders particularly Parkinson s disease models
TARGETMOL CHEMICALS INC 6-Acryloyloxyhexyl phosphate
Also available in 5 mg, 10 mg, 25 mg, 50 mg and bulk. Please contact Fisher for quotes. 6-Acryloyloxyhexyl phosphater (PA21) is a novel phosphate-binding agent, which is an iron-based reagent, and can be used for the treatment of hyperphosphatemia in chronic kidney disease. Purity ≥98%
Medchemexpress LLC 1,2-Dioleoyl-sn-glycero-3-phosphocholine | 4235-95-4 | 99.9% | 786.11 | 1 G
1,2-Dioleoyl-sn-glycero-3-phosphocholine | 4235-95-4 | 99.9% | 786.11 | 1 G
Apexbio Technology LLC AICAR phosphate 681006-28-0 50mg
AICAR phosphate (CAS 681006-28-0) also known as Acadesine is an activator of AMP-activated protein kinase (AMPK) In studies involving B-cell chronic lymphocytic leukemia (B-CLL) cells AICAR phosphate induces apoptosis in a dose-dependent manner with an EC50 of approximately 380 60 M This apoptotic effect is associated with caspase activation and mitochondrial cytochrome c release Notably AICAR phosphate at concentrations of 2 4 mM has minimal impact on T lymphocyte viability from B-CLL patients indicating selective activity These properties make it a valuable tool for research on AMPK signaling and B-cell malignancy mechanisms
Medchemexpress LLC Diphenyl Phosphate | 838-85-7 | 250.19 | 5 G
Diphenyl Phosphate is a metabolic inhibitor that impacts growth and energy metabolism in zebrafish and mice in a sex-specific manner. It functions by inhibiting the activity of Succinate Dehydrogenase (SDH), which is a component of respiratory complex II. Additionally, it reduces the expression of Carnitine Palmitoyltransferase 1 (CPT1) and disrupts the integrity of the mitochondrial membrane. This compound is suitable for research related to metabolic diseases.
- Inhibits growth and energy metabolism.
- Specifically affects SDH (respiratory complex II) and CPT1.
- Disrupts mitochondrial membrane integrity.
- Useful in research on metabolic diseases.
Medchemexpress LLC KN-93 (phosphate) | 1913269-12-1 | C26H32ClN2O8PS | 50 MG
KN-93 phosphate is a cell-permeable, reversible, and competitive inhibitor of calmodulin-dependent kinase type II (CaMKII) with a Ki of 370 nM. It is intended for research use only and is not sold to patients. This product typically appears as a white to off-white solid.
- Cell-permeable and reversible
- Specific CaMKII inhibitor
- Induces G1 cell cycle arrest and apoptosis
- Inhibits cell growth stimulated by various growth factors in NIH 3T3 fibroblasts
- Impacts H+, K+-ATPase activity
- Prevents early afterdepolarizations
- High purity (99.72%)
Crescent Chemical Co Inc NAPHTHOL-AS-BI-PHOSPHATE
Naphthol-AS-BI-phosphate research grade Histochemical substrate for phosphatase. Size - 500MG Storage Conditions - -15 °C TO -25 °C Catalog Number - 29988.02 CAS 1919-91-1
Research Products International Corp Pyridoxal-5-Phosphate 100 G
- CAS Number: 41468-25-1
- Molecular Formula: C8H10NO6P • H2O
- Molecular Weight: 265.15 g/mol
Medchemexpress LLC Fingolimod phosphate | 402615-91-2 | C19H34NO5P | 1 MG
Fingolimod phosphate is an orally active sphingosine 1-phosphate (S1P) receptor agonist. It promotes the neuroprotective effects of microglia and is used for research on multiple sclerosis and neurological diseases.
- Orally active S1P receptor agonist
- Promotes neuroprotective effects of microglia
- Used for research on multiple sclerosis
- Used for research on neurological diseases
- Prevents lymphocytes from moving out of lymphoid organs
- Inhibits autoreactive lymphocytes from infiltrating the central nervous system
- Downregulates pro-inflammatory cytokines in activated microglia
- Upregulates brain-derived neurotrophic factor and glial cell-derived neurotrophic factor production in microglia
Medchemexpress LLC Fingolimod phosphate | 402615-91-2 | C19H34NO5P | 5 MG
Fingolimod phosphate is an orally active sphingosine 1-phosphate (S1P) receptor agonist. It promotes the neuroprotective effects of microglia and is used for the research of multiple sclerosis and neurologic diseases. In vitro, it prevents lymphocytes from moving out of lymphoid organs and inhibits autoreactive lymphocytes from infiltrating the central nervous system.
- Orally active sphingosine 1-phosphate (S1P) receptor agonist
- Promotes neuroprotective effects of microglia
- Used for research of multiple sclerosis and neurologic diseases
- Prevents lymphocytes from moving out of lymphoid organs
- Inhibits autoreactive lymphocytes from infiltrating the central nervous system
- Downregulates activated microglial production of pro-inflammatory cytokines
- Upregulates microglial production of brain-derived neurotrophic factor and glial cell-derived neurotrophic factor
Chem-Impex International, Inc. Dibenzyl phosphate | 1623-08-1 | MFCD00004775 | 100G
Dibenzyl phosphate, 1623-08-1, MFCD00004775, 100G