Organic phosphoric acids and derivatives
Apexbio Technology LLC 3PO(Synonyms: 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one, 3-(3-Pyridyl)-1-(4-pyridyl)-2-propen-1-one), 50mg, CAS: 13309-08-5; 18550-98-6.
3PO (CAS 13309-08-5 18550-98-6) is a small molecule inhibitor targeting 6-phosphofructo-2-kinase (PFKFB3) a regulatory enzyme involved in cellular glucose metabolism Its mode of action involves inhibiting PFKFB3 activity leading to reduced intracellular synthesis of fructose-2 6-bisphosphate and consequently decreased glycolytic flux By perturbing glucose metabolism 3PO modulates cellular proliferation growth and survival pathways The compound is widely used in cell and animal model studies exploring tumor metabolism metabolic disorders and immunometabolism
Medchemexpress LLC 2-Propen-1-one, 3-(3-pyridinyl)-1-(4-pyridinyl)-, (2E)- | 18550-98-6 | 99.0% | 210.23 | 25 MG
3PO is an inhibitor of PFKFB3, used in cancer research. It attenuates the proliferation of several cancer cell lines with IC50s of 1.4-24 μmol/L. 3PO suppresses glucose uptake and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+ and NADH.
- Inhibits Jurkat cells proliferation by influencing the cell cycle.
- Suppresses glycolytic flux to lactate in Jurkat cells.
- Inhibits cellular proliferation of transformed tumor cell lines.
- Inhibits Jurkat T cells proliferation by G2-M phase cell cycle arrest.
- Decreases lactate secretion, NADH, NAD+, and ATP in Jurkat cells.
- Inhibited solid tumor and hematologic cell lines (Jurkat, K562, HL-60, MDA-MB231, HeLa, Melanoma, and Lewis Lung) with IC50s of 1.4-24 μM/L.
Cambridge Isotope Laboratories Di-n-Hexyl phthalate (unlabeled) 100 ug/mL in nonane 1 2 mL
Di-n-Hexyl phthalate (unlabeled) 100 ug/mL in nonane 1 2 mL
Medchemexpress LLC Methyl trioctyl ammonium chloride | 5137-55-3 | MFCD00011862 | 98.0% | 404.16 g/mol | C25H54ClN | 100g
Methyl trioctyl ammonium chloride is a quaternary ammonium salt commonly used as a surfactant stabilizer and phase transfer catalyst in various chemical reactions especially in organic synthesis Methyl trioctyl ammonium chloride has unique chemical properties that facilitate the transfer of ions or molecules from one phase to another making it an important ingredient in a variety of industrial processes
Medchemexpress LLC 2-Propen-1-one, 3-(3-pyridinyl)-1-(4-pyridinyl)- | 13309-08-5 | 99.9% | 210.24 | 1 ML
(E/Z)-3PO is a potent PFKFB3 inhibitor available as an off-white to light yellow solid. This compound has a molecular formula of C13H10N2O and a molecular weight of 210.24, with a high purity of 99.9% by LCMS. It is intended for laboratory research use only.
- Potent PFKFB3 inhibitor
- High purity for reliable research
- Off-white to light yellow solid form
- Suitable for various laboratory applications
Medchemexpress LLC Phosphoric acid tributyl ester-d27 | 61196-26-7 | 100.0% | 293.48 | C12D27O4P | 50 MG
Deuterium-labeled tributyl phosphate (Tributyl phosphate-d27) supplied as a 50 mg solid for research use. It is intended as an internal standard and tracer for analytical techniques including NMR, GC-MS, and LC-MS, and is suitable for quantitative and structural studies. Store and handle under recommended conditions to preserve isotopic and chemical integrity.
- Deuterium-labeled internal standard for NMR, GC-MS, and LC-MS
- High isotopic purity for accurate quantitation
- Soluble in DMSO at ≥100 mg/mL for convenient stock preparation
- Suitable for use as a tracer or internal standard in analytical workflows
- Stable as a solid when stored at -20°C under recommended conditions
Cambridge Isotope Laboratories TRIBUTYL PHOSPHATE (D27, 98-99%), 1 G, 61196-26-7
TRIBUTYL PHOSPHATE (D27, 98-99%), 1 G, 61196-26-7
Medchemexpress LLC Tributyl phosphate-d27 | 61196-26-7 | MFCD01861663 | 100.0% | 293.48 g·mol⁻¹ | C12D27O4P | 25 MG
Tributyl phosphate-d27 is the deuterium-labeled analog of tributyl phosphate supplied as a high-purity isotopically labeled reagent for use as a tracer and as an internal standard in quantitative analytical methods. It is intended for laboratory research use and available in small, analytical-scale packages suitable for method development and validation.
- Deuterium-labeled internal standard for NMR, GC-MS, and LC-MS.
- High chemical purity (GC) supports accurate quantitation.
- Isotopically enriched to enable tracer and mass-shift applications.
- Small packaging options ideal for analytical method development.
- Stable under recommended storage conditions for labeled reagents.