Vinylogous acids
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Medchemexpress LLC Pseudoprotodioscin | 102115-79-7 | 1031.18 | 5 MG
Pseudoprotodioscin is a furostanoside that inhibits SREBP1/2 and microRNA 33a/b levels, leading to a reduction in the gene expression responsible for the synthesis of cholesterol and triglycerides. It is intended for research use only.
- Inhibits SREBP1/2 and microRNA 33a/b levels.
- Reduces gene expression related to cholesterol and triglyceride synthesis.
- Increases ABCA1 protein and mRNA levels.
- Promotes ApoA-1-mediated cholesterol efflux.
- Reduces HMGCR, FAS, and ACC mRNA levels.
- Promotes low-density lipoprotein receptor by decreasing PCSK9 levels.
- Purity: 99.17%.
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Medchemexpress LLC IACS-8803 disodium | 2243079-36-7 | C20H21FN10Na2O9P2S2 | 10MG
IACS-8803 disodium is a cyclic dinucleotide stimulator of interferon genes (STING) agonist described by investigators at the Institute for Applied Cancer Science (MD Anderson). Supplied as the disodium salt for research use, it shows robust systemic antitumor efficacy in preclinical studies and includes documented solubility and formulation guidance for in vitro and in vivo experiments.
- Potent activation of the STING pathway demonstrated in preclinical studies.
- Water-soluble disodium salt with documented solubility in DMSO, water, and PBS.
- Suggested in vivo formulations and dosing vehicles provided for clear solution preparation.
- High chemical purity suitable for laboratory research applications.
- Intended for research use only; not for human or clinical use.