Azetidines
Medchemexpress LLC NSC319726 (ZMC1) | 71555-25-4 | 99.6% | 234.32 | 100 MG
NSC319726 (ZMC1) is a mutant p53R175 reactivator. It inhibits the growth of fibroblasts expressing the p53R175 mutation with an IC50 of 8 nM, showing no inhibition for p53 wild-type cells. This compound has demonstrated significant inhibition of tumor growth in TOV112D (p53R175H) xenografts in vivo, providing evidence for allele-specific p53 mutant reactivation.
- Mutant p53R175 reactivator with IC50 of 8 nM against p53R175 mutation
- No inhibition for p53 wild-type cells
- High sensitivity for MEF-p53R172H/R172H cell line
- Inhibits tumor growth in TOV112D (p53R175H) xenografts in vivo
- Provides in vivo evidence for allele-specific p53 mutant reactivation
- CC50 < 0.02 μM for Caco-2 cell toxicity
- IC50 < 0.02 μM for Caco-2 cell SARS-CoV-2 cytotoxicity inhibition
- EC50 0.005 μM for TOV112D cell growth inhibition
eMolecules 914348-04-2 | 3-(Cbz-amino)azetidine | MFCD07368913 | 1g
Combi-Blocks | 3-(Cbz-amino)azetidine | 1g | 401042394 | QB-2409 | 96.000 | 914348-04-2 | MFCD07368913 | 206.245 | C11H14N2O2
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![eMolecules ChemScene / (R)-Azetidine-2-carbonitrileoxalate / 100mg / 714104305 / CS-0172824 / 0.000 / 2173052-89-4 / [null] / 172.140 / C6H8N2O4](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502463335.JPG-250.jpg)
eMolecules ChemScene / (R)-Azetidine-2-carbonitrileoxalate / 100mg / 714104305 / CS-0172824 / 0.000 / 2173052-89-4 / [null] / 172.140 / C6H8N2O4
ChemScene / (R)-Azetidine-2-carbonitrileoxalate / 100mg / 714104305 / CS-0172824 / 0.000 / 2173052-89-4 / [null] / 172.140 / C6H8N2O4
Medchemexpress LLC 1-Boc-L-azetidine-2-carboxylic acid | 51077-14-6 | 201.22 | 5 G
1-Boc-L-azetidine-2-carboxylic acid is a biochemical reagent that can be utilized as a biological material or organic compound in life science related research.
- Suitable for life science research
- For research use only
- Not for patient use
Medchemexpress LLC 1-Boc-L-azetidine-2-carboxylic acid | 51077-14-6 | 201.22 | 1 G
(S)-1-(tert-Butoxycarbonyl)azetidine-2-carboxylic acid is a biochemical reagent. It can be utilized as a biological material or organic compound for life science related research.
- Can be used as a biological material
- Can be used as an organic compound
- Suitable for life science related research
eMolecules 1187929-85-6 | 3-Isopropoxy-azetidine oxalate | J & W PharmLab LLC | MFCD11506051 | 205.210 | C8H15NO5 | 96.000 | OC(=O)C(O)=O.CC(C)OC1CNC1 | 5g | 289351444
3-Isopropoxy-azetidine oxalate | J & W PharmLab LLC | 1187929-85-6 | MFCD11506051 | 205.210 | C8H15NO5 | 96.000 | OC(=O)C(O)=O.CC(C)OC1CNC1 | 5g | 289351444