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Medchemexpress, HY-111371 5mg PF-05180999 CAS:1394033-54-5 PF-05180999 is a phosphodiesterase 2A (PDE2A) inhibitor, with an IC50 of 1.6 nM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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(S)-1-(tert-Butoxycarbonyl)azetidine-2-carboxylic acid is a biochemical reagent. It can be utilized as a biological material or organic compound for life science related research.
Can be used as a biological material
Can be used as an organic compound
Suitable for life science related research
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1-Boc-D-azetidine-2-carboxylic acid is a Boc-protected D-azetidine amino acid derivative used as a chemical intermediate in medicinal chemistry and organic synthesis. It serves as a protected building block for introducing an azetidine unit into peptides and small molecules; intended for research use only.
Boc-protected azetidine scaffold for synthetic incorporation.
Suitable for peptide and small-molecule synthesis.
Available in multiple pack sizes for scale flexibility.
Typical purity ≥97% as supplied.
Molecular formula C9H15NO4; molecular weight 201.22 g·mol⁻¹.
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool<|a>
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NSC319726 (ZMC1) is a mutant p53R175 reactivator. It inhibits the growth of fibroblasts expressing the p53R175 mutation with an IC50 of 8 nM, showing no inhibition for p53 wild-type cells. This compound has demonstrated significant inhibition of tumor growth in TOV112D (p53R175H) xenografts in vivo, providing evidence for allele-specific p53 mutant reactivation.
Mutant p53R175 reactivator with IC50 of 8 nM against p53R175 mutation
No inhibition for p53 wild-type cells
High sensitivity for MEF-p53R172H/R172H cell line
Inhibits tumor growth in TOV112D (p53R175H) xenografts in vivo
Provides in vivo evidence for allele-specific p53 mutant reactivation
CC50 < 0.02 μM for Caco-2 cell toxicity
IC50 < 0.02 μM for Caco-2 cell SARS-CoV-2 cytotoxicity inhibition
EC50 0.005 μM for TOV112D cell growth inhibition
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Azetidine-2-carboxylic acid (L-Aze) is a toxic and teratogenic non-protein amino acid that is misincorporated into protein in place of proline altering collagen keratin hemoglobin and protein folding
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Clavulanate lithium is a potent beta-lactamase inhibitor that also acts as an antibiotic. While exhibiting weak antibacterial activity alone, it prevents the inactivation of beta-lactam antibiotics by microbial lactamase when combined with them. It has a molecular weight of 205.09 and an appearance of a solid, white to off-white color.
Potent beta-lactamase inhibitor
Acts as an antibiotic
Prevents inactivation of beta-lactam antibiotics
Solid, white to off-white appearance
Soluble in H2O and DMSO
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