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Azetidine-2-carboxylic acid is a non-proteinogenic amino acid homologue of proline. It is naturally found in common beets and can be misincorporated into proteins across various species, including humans. This compound is also recognized for its toxic and teratogenic properties, making it a valuable tool for specific research applications.
Non-proteinogenic amino acid
Homologue of proline
Found in common beets
Can be misincorporated into proteins
Toxic and teratogenic agent for research purposes
Minimum purity of 98.0%
Appears as a white to off-white solid
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1-Boc-D-azetidine-2-carboxylic acid is a Boc-protected azetidine building block used as a drug intermediate for synthesizing pharmaceutical and bioactive molecules. Supplied as a solid (CAS 228857-58-7; MW 201.22 g·mol⁻1), it is intended for organic synthesis and intermediate-scale reactions. Powder is stable at room temperature; solutions require low-temperature storage.
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L-azetidine-2-carboxylic acid is a proline analog research reagent used to study protein folding, endoplasmic reticulum (ER) stress, autophagy, and apoptosis pathways. It is supplied as a solid and as a 10 mM solution in water and has reported high chemical purity.
Proline analog that perturbs protein synthesis and folding
Induces ER stress and protein misfolding
Upregulates LC3-II via PERK activation (autophagy marker)
Increases pro-apoptotic BAX and induces ATF6 cleavage
Available as solid and as a 10 mM, 1 mL aqueous solution
High purity, reported at 99.85%
CAS number 2133-34-8; formula C4H7NO2; molecular weight 101.10 g/mol
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1-Boc-D-azetidine-2-carboxylic acid is a Boc-protected azetidine-derived amino acid used as a synthetic building block and drug intermediate in medicinal chemistry research. Supplied as a white to off-white solid, it is provided with batch analytical data for quality confirmation.
CAS registry number: 228857-58-7.
Molecular formula: C9H15NO4.
Molecular weight: 201.22 g/mol.
Purity (HPLC): 98.96%.
Appearance: white to off-white solid.
Storage and shelf life: store at room temperature, shelf life 3 years; in solvent, -80°C for 2 years or -20°C for 1 year.
Available pack sizes: 250 mg, 500 mg, 1 g, 5 g, 10 g, 25 g, 50 g.
Supplied with a certificate of analysis for batch-specific data.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More