Azetidines
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Medchemexpress LLC Biotinylated covalent Btk inhibitor (CC-292) | 1202758-21-1 | 99.9% | 961.18 g/mol | C48H68N10O9S | 5 MG
CNX-500 is a biotinylated covalent probe created by linking a covalent Btk inhibitor to biotin. It retains potent inhibitory activity against Bruton's tyrosine kinase (Btk) with an IC50 of 0.5 nM and is intended for biochemical and cellular target engagement, labeling, and affinity-capture workflows.
- Covalent binding to Btk enabling irreversible target labeling.
- Biotin tag for affinity capture and pulldown experiments.
- High potency (Btk IC50 = 0.5 nM) for sensitive detection of engagement.
- High purity (>99.8%) suitable for research applications.
- Soluble in DMSO at 100 mg/mL; formulations reported for in vivo dosing.
- Stable as powder when stored at -20°C for long-term storage.
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Medchemexpress LLC Biotinylated covalent Btk inhibitor (CC-292) | 1202758-21-1 | 99.9% | 961.18 g/mol | C48H68N10O9S | 10 MG
CNX-500 is a biotinylated probe consisting of a covalent Bruton's tyrosine kinase (BTK) inhibitor chemically linked to biotin; it retains potent inhibitory activity (reported IC50 ≈ 0.5 nM) and is intended for target engagement and affinity-based experiments.
- Biotin tag enables affinity capture and pull-down assays.
- Covalent BTK inhibitor provides irreversible labeling of the target.
- High potency toward BTK (IC50 ~0.5 nM) for sensitive detection.
- High purity reduces off-target background.
- Suitable for biochemical and affinity-based proteomics applications.
- Stable under recommended storage conditions for long-term use.