Azobenzenes
Medchemexpress LLC Methylglyoxal-bis(guanylhydrazone) | 459-86-9 | MFCD00067519 | ≥98.0% | 184.20 g·mol⁻¹ | C5H12N8 | 50 MG
Mitoguazone (methylglyoxal-bis(guanylhydrazone)) is a small-molecule research reagent that competitively inhibits S-adenosyl-methionine decarboxylase (SAMDC) and disrupts polyamine biosynthesis. It is used in biochemical and cellular studies to probe polyamine-dependent processes, mitochondrial effects, and apoptosis. Chemical identifiers include CAS 459-86-9, formula C5H12N8, and molecular weight 184.20 g·mol⁻¹.
- Competitive inhibitor of S-adenosyl-methionine decarboxylase (SAMDC).
- Disrupts polyamine biosynthesis for pathway and apoptosis research.
- Reported to be brain-penetrant and useful in cellular assays.
- Characterized chemical identifiers: CAS 459-86-9, formula C5H12N8, MW 184.20 g·mol⁻¹.
- Recommended storage sealed and away from moisture; in solvent: -80°C long-term, -20°C short-term.
- Reported supplier purity commonly ≥98% for research-grade material.
Medchemexpress LLC Valategrast (R-411 free base) | 220847-86-9 | 97.1% | C30H32Cl3N3O4 | 100 MG
Valategrast (R-411 free base) is a potent and orally active dual antagonist of integrin α4β1 (VLA-4) and α4β7, showing potential for treating Chronic Obstructive Pulmonary Disease (COPD) and asthma. It features a l-phenylalanine-N-aroyl motif, with its carboxylic acid binding to the metal ion in the metal-ion-dependent adhesion site (MIDAS).
- CAS no.: 220847-86-9
- Molecular weight: 604.95
- Formula: C30H32Cl3N3O4
- Appearance: Off-white to light yellow solid
- Solubility: ≥ 4.25 mg/mL (7.03 mM) in various in vivo dissolution methods
- Storage: -80°C, stored under nitrogen