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Medchemexpress LLC N-cycloheptyl-6,7-dimethoxy-2-(4-piperidin-1-ylpiperidin-1-yl)quinazolin-4-amine | 864289-85-0 | 100.0% | 467.65 g/mol | C27H41N5O2 | 50 MG
C-021 is a small-molecule antagonist of CC chemokine receptor 4 (CCR4) developed for research applications; it blocks CCR4-mediated signaling and functional chemotaxis, with low-nanomolar activity in binding and cell-based assays.
- Potent CCR4 antagonist with low-nanomolar binding activity.
- Prevents CCL22-derived [35S]GTPγS binding to CCR4 (IC50 18 nM) and inhibits functional chemotaxis (human 140 nM, mouse 39 nM).
- Molecular formula C27H41N5O2; molecular weight 467.65 g/mol.
- High purity (~99.95%).
- Solid form with recommended storage: powder -20°C (long term) or 4°C (short term); in solvent store at -80°C.
- Intended for research use only; not for human use.
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Medchemexpress LLC C-021 | 864289-85-0 | 100.0% | 467.65 g/mol | C27H41N5O2 | 25 MG
C-021 is a small-molecule CCR4 antagonist supplied for research use. It inhibits CCR4-mediated chemotaxis in human and mouse cells and blocks CCL22-induced GTPγS binding, making it suitable for biochemical and cellular assays.
- Target: CCR4 (GPCR), suitable for immunology and GPCR research.
- Potent CCR4 antagonist with reported IC50s of 140 nM (human chemotaxis), 39 nM (mouse chemotaxis), and 18 nM in GTPγS binding assays.
- Molecular formula C27H41N5O2 and molecular weight 467.65 g/mol.
- Reported purity 99.95% and solid appearance (off-white to light yellow).
- Recommended storage: powder -20°C (up to 3 years) or 4°C (up to 2 years); in solvent -80°C (6 months) or -20°C (1 month).
- Intended for research use only; not for human or animal therapeutic use.