Azobenzenes

11-[4-(4-Butylphenylazo)phenoxy]undecyl Methacrylate 97.0+%, TCI America™

CAS: 942230-11-7 Molecular Formula: C31H44N2O3 Molecular Weight (g/mol): 492.704 MDL Number: MFCD06797121 InChI Key: YKWVMKBZDQOJNN-UHFFFAOYSA-N Synonym: Methacrylic Acid 11-[4-(4-Butylphenylazo)phenoxy]undecyl Ester PubChem CID: 44630394 IUPAC Name: 11-[4-[(4-butylphenyl)diazenyl]phenoxy]undecyl 2-methylprop-2-enoate SMILES: CCCCC1=CC=C(C=C1)N=NC2=CC=C(C=C2)OCCCCCCCCCCCOC(=O)C(=C)C

Dabsyl-L-valine 98.0+%, TCI America™

CAS: 89131-11-3 Molecular Formula: C19H24N4O4S Molecular Weight (g/mol): 404.485 MDL Number: MFCD00059366 InChI Key: AJSKPBGSGLIRQK-SFHVURJKSA-N Synonym: 4-Dimethylaminoazobenzene-4′C-sulfonyl-L-valine, Dbs-Val-OH PubChem CID: 14048723 IUPAC Name: (2S)-2-[[4-[[4-(dimethylamino)phenyl]diazenyl]phenyl]sulfonylamino]-3-methylbutanoic acid SMILES: CC(C)C(C(=O)O)NS(=O)(=O)C1=CC=C(C=C1)N=NC2=CC=C(C=C2)N(C)C

Medchemexpress LLC PR5-LL-CM01, a protein arginine methyltransferase 5 (PRMT5) inhibitor | 1005307-86-7 | 98.4% | 401.51 | 1 ML

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Small and/or specialty supplier based on Federal laws and SBA requirements.
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PR5-LL-CM01 is a potent protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 7.5 μM. It exhibits anti-tumor activities. It has a range of IC50 at 2-4 μM in PDAC cells (PANC1, MiaPaCa2 and AsPC1) and 10-11 μM in CRC cells (HT29, HCT116 and DLD1). PR5-LL-CM01 specifically inhibits cancer cells with low toxicity in normal cells and strongly inhibits colony forming ability in PANC1 and HT29 cells. It also inhibits NF-κB activation and its target gene expression, dramatically decreasing TNFα and IL8 expression in both PANC1 and HT29 cells.

• Potent PRMT5 inhibitor.
• Exhibits anti-tumor activities.
• Low toxicity in normal cells.
• Strongly inhibits colony forming ability in PANC1 and HT29 cells.
• Inhibits NF-κB activation and its target gene expression.
• Decreases TNFα and IL8 expression.

Medchemexpress LLC PR5-LL-CM01 | 1005307-86-7 | 98.4% | 401.51 | 50 MG

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More

PR5-LL-CM01 is a potent protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 7.5 μM. It exhibits anti-tumor activities and demonstrates efficacy in inhibiting cancer cells while showing low toxicity in normal cells.

• Has IC50 values ranging from 2-4 μM in PDAC cells (PANC1, MiaPaCa2, and AsPC1) and 10-11 μM in CRC cells (HT29, HCT116, and DLD1).
• Strongly inhibits colony-forming ability in both PANC1 and HT29 cells.
• Inhibits NF-κB activation and its target gene expression in PDAC and CRC cells.
• Significantly decreases TNFα and IL8 expression in both PANC1 and HT29 cells (at 0-15 μM).
• Shows significant anti-tumor effects in PANC1 and HT29 xenografted mice in vivo (20 mg/kg; i.p.; 3 times per week) without visibly affecting their body weight.