Benzodiazepines
Abcam N-Desmethyl clozapine (Normethylclozapine), Clozapine metabolite. M1 agonist. D2/D3 agonist., 50MG
MW 312.8 Da, Purity >99%. Brain penetrant metabolite of the atypical antipsychotic clozapine. Broad range of actions. Potent allosteric M1 partial agonist (IC50 = 55 nM for inhibition of [3H]-NMS binding). D2/D3 partial agonist. Also displays affinity at 5-HT1 and 5-HT2.
The product is subject to the following: Abcam Restricted Use Statement
Abcam N-Desmethyl clozapine (Normethylclozapine), Clozapine metabolite. M1 agonist. D2/D3 agonist., 10MG
MW 312.8 Da, Purity >99%. Brain penetrant metabolite of the atypical antipsychotic clozapine. Broad range of actions. Potent allosteric M1 partial agonist (IC50 = 55 nM for inhibition of [3H]-NMS binding). D2/D3 partial agonist. Also displays affinity at 5-HT1 and 5-HT2.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC Clozapine N-oxide | 34233-69-7 | 99.9% | 342.82 | 25 MG
Clozapine N-oxide is a major metabolite of Clozapine, acting as an agonist for human muscarinic designer receptors (DREADDs). It activates the hM3Dq and hM4Di DREADD receptors, but it cannot cross the blood-brain barrier. Its parent compound, Clozapine, is a potent dopamine antagonist and a selective muscarinic M4 receptor agonist.
- Activates DREADD receptors hM3Dq and hM4Di
- Cannot cross the blood-brain barrier
- Metabolite of Clozapine
- Solid appearance
- Light yellow to yellow color
Medchemexpress LLC Clozapine N-oxide | 34233-69-7 | 99.9% | 342.82 | 50 MG
Clozapine N-oxide is a major metabolite of Clozapine and acts as an agonist for human muscarinic designer receptors (DREADDs). It activates the DREADD receptors hM3Dq and hM4Di. Clozapine N-oxide cannot cross the blood-brain barrier. It undergoes reverse-metabolism to its parent compound clozapine, an atypical antipsychotic.
- Activates DREADD receptors hM3Dq and hM4Di
- Cannot cross the blood-brain barrier
- Undergoes reverse-metabolism to clozapine
- Suitable for laboratory centrifugation and storage
Medchemexpress LLC Clozapine N-oxide | 34233-69-7 | 99.98% | 342.82 | 50 MG
Clozapine N-oxide is a major metabolite of Clozapine and acts as a human muscarinic designer receptors (DREADDs) agonist. It activates the DREADD receptor hM3Dq and hM4Di but cannot cross the blood-brain barrier. Clozapine, its parent compound, is a potent dopamine antagonist and a selective muscarinic M4 receptor agonist.
- Activates DREADD receptor hM3Dq and hM4Di.
- For research use only.
- Provides details on solubility and stability in various solvents for both in vitro and in vivo applications.
- Cited in numerous top publications from various scientific journals.
Medchemexpress LLC Coelenterazine | 55779-48-1 | 98.5% | 423.46 | 25 MG
Coelenterazine is a luminescent enzyme substrate for apoaequorin and Renilla luciferase. It has been utilized as a bioluminescence donor in bioluminescence resonance energy transfer (BRET) for detecting protein-protein interactions. It also serves as a superoxide anion-sensitive chemiluminescent probe and can be employed in the chemiluminescent detection of peroxynitrite.
- Functions as a luminescent enzyme substrate
- Used as a bioluminescence donor in BRET for protein-protein interaction detection
- Acts as a superoxide anion-sensitive chemiluminescent probe
- Can be used for chemiluminescent detection of peroxynitrite (Ex/Em = 429/466 nm)
Medchemexpress LLC Clozapine (Standard) | 5786-21-0 | 99.98% | C₁₈H₁₉ClN₄ | 100 MG
Clozapine (Standard) is the analytical standard of Clozapine, intended for research and analytical applications. It is an antipsychotic used for the research of schizophrenia. Clozapine exhibits high affinity for various neuroreceptors, acting as a potent antagonist of dopamine D2 and inhibiting muscarinic M1 and serotonin 5HT2A receptors. It is also a potent and selective agonist at the muscarinic M4 receptor.
- Intended for research and analytical applications
- Analytical standard of Clozapine
- Used for schizophrenia research
- Potent antagonist of dopamine D2
- Inhibits muscarinic M1 and serotonin 5HT2A receptors
- Potent and selective agonist at the muscarinic M4 receptor
- Used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS