Benzoxadiazoles
Medchemexpress LLC 3-NBD-C12 cholesterol | 186833-02-3 | MFCD00075336 | 10 MG
3-NBD-C12 cholesterol is an NBD-tagged fluorescent cholesterol analog used to study cholesterol uptake, membrane incorporation, intracellular trafficking, and metabolism in biological systems. The NBD fluorophore enables visible-range fluorescence detection for microscopy and spectroscopy; supplied as a solid for research use.
- NBD fluorophore with typical excitation ≈465 nm and emission ≈535 nm
- Suitable for studies of membrane dynamics and cholesterol trafficking
- Soluble in DMF and DMSO for stock solutions with recommended handling
- Solid, yellow to orange appearance for easy visual identification
- Store protected from light; use cold storage for solutions to maintain stability
Medchemexpress LLC Int-767 | 1000403-03-1 | 99.8% | 494.66 g/mol | C25H43NaO6S | 10MG
INT-767 is a semisynthetic dual farnesoid X receptor (FXR) and TGR5 (GPBAR1) agonist used in preclinical research to modulate bile acid signaling, liver, and metabolic pathways. The compound shows mean EC50s of 30 nM for FXR and 630 nM for TGR5, and is supplied as the sodium salt with high reported purity.
Medchemexpress LLC NBD-Pen | 1955505-54-0 | 99.94% | 25 MG
NBD-Pen is the first fluorescence probe for lipid radicals, offering high selectivity and sensitivity (λex: 470 nm, λem: 530 nm). It specifically detects lipid-derived radicals over other reactive species in biological systems. It directly detects lipid radicals in living cells by turn-on fluorescence and can decrease inflammation, apoptosis, and oxidative stress markers. This probe can be studied in various disease models, such as hepatic carcinoma.
- First fluorescence probe for lipid radicals
- High selectivity and sensitivity (λex: 470 nm, λem: 530 nm)
- Detects lipid-derived radicals over other reactive species
- Directly detects lipid radicals in living cells by turn-on fluorescence
- Decreases inflammation, apoptosis, and oxidative stress markers
- Can be studied in various disease models
Medchemexpress LLC 6alpha-ethyl-3alpha,7alpha,23-trihydroxy-24-nor-5beta-cholan-23-sulfate sodium salt | 1000403-03-1 | 98.0% | 494.7 g/mol | C25H43NaO6S | 1MG
INT-767 is a semisynthetic bile acid-derived small molecule used in preclinical research as a potent dual agonist of the farnesoid X receptor (FXR) and the G protein-coupled bile acid receptor TGR5. It modulates bile acid signaling and has been studied in liver and metabolic disease models in vitro and in vivo.
Medchemexpress LLC A 410099.1, amine-Boc hydrochloride | 2374122-37-7 | 99.7% | 620.22 g/mol | C32H50ClN5O5 | 5 MG
A 410099.1, amine-Boc hydrochloride is a Boc-protected amine derivative of an IAP ligand supplied as the hydrochloride salt. It is intended as a functionalized building block for the synthesis of proteolysis-targeting chimeras (PROTACs), including BTK-targeting PROTACs, and is provided for research and medicinal chemistry applications.
- High purity (99.7%) suitable for synthesis workflows.
- Boc-protected amine functionality for facile deprotection and conjugation.
- Hydrochloride salt form improves handling and stability.
- Compatible with PROTAC assembly and medicinal chemistry derivatization.
- Available in small mg packaging for research-scale use.
eMolecules 33984-50-8 | Medchem Express | MBD | 100mg | 642185116 | HY-141667 | MFCD00042778 | 300.274 | C14H12N4O4
Medchem Express | AG-024322 | 5mg | 649809005 | HY-15491 | 837364-57-5 | 418.452 | C23H20F2N6
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Medchemexpress LLC 1H-Pyrrole-2-carboxamide, N-[(1S)-2-amino-1-[4-(hydroxymethyl)-2-thiazolyl]ethyl]-5-[3-fluoro-4-(trifluoromethyl)phenyl]- | 2234273-72-2 | 99.8% | 428.40 | 1 ML
NBD-14189 is a potent HIV-1 entry antagonist with an IC50 of 89 nM against the HIV-1HXB2 pseudovirus. It binds to HIV-1 gp120 and demonstrates potent antiviral activity (EC50 < 200 nM). It is intended for research use only.
- Potent HIV-1 entry antagonist
- Binds to HIV-1 gp120
- Shows potent antiviral activity (EC50<200 nM)
- Anti-HIV-1 activity (IC50=0.089 μM) in single-cycle (TZM-bl cells) assays
- Prevents HIV-1 mediated cell-cell fusion
Medchemexpress LLC NBD-14189 | 2234273-72-2 | 99.8% | 428.40 | 25 MG
NBD-14189 is a potent HIV-1 entry antagonist that binds to HIV-1 gp120, exhibiting potent antiviral activity. It demonstrates anti-HIV-1 activity and cytotoxicity in both single-cycle (TZM-bl cells) and multi-cycle (MT-2 cells) assays, and prevents HIV-1 mediated cell-cell fusion.
- Potent HIV-1 entry antagonist (IC50 of 89 nM against HIV-1HXB2 pseudovirus)
- Binds to HIV-1 gp120
- Potent antiviral activity (EC50<200 nM)
- Anti-HIV-1 activity (IC50=0.089 μM) and cytotoxicity (CC50=21.9 μM) in single-cycle assays
- Anti-HIV-1 activity (IC50=0.18 μM) and cytotoxicity (CC50=22.1 μM) in multi-cycle assays
- Prevents HIV-1 mediated cell-cell fusion (IC50=9.4 μM)
- Weak or no inhibition of hERG current (IC50=3.0 μM)
Medchemexpress LLC Nbd-14270 | 2411819-82-2 | 99.5% | 425.43 | C18H18F3N5O2S | 5 MG
NBD-14270 is a pyridine analogue that functions as a potent HIV-1 entry antagonist by binding to the gp120 envelope protein. It exhibits sub-micromolar antiviral activity with low cytotoxicity and is provided for research applications with characterized purity, formula, and storage recommendations.
- High purity: 99.53%.
- Chemical formula: C18H18F3N5O2S; molecular weight: 425.43.
- CAS number: 2411819-82-2.
- Recommended solvent: DMSO; use ultrasonic aid for dissolution.
- Storage: solid at 4°C; in solvent store at -80°C for long-term stability.
- Typical applications: in vitro antiviral and HIV-1 entry assays.
Medchemexpress LLC 4-(Aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole | 91366-65-3 | 98.8% | 25 MG
4-(Aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole (ABD-F) is a fluorescent reagent used for the sensitive and specific detection of thiols. It has an excitation/emission (Ex/Em) of 380/510 nm. It exhibits low fluorescence background and good stability of fluorophor, making it suitable for various research applications.
- Sensitive and specific detection of thiols.
- Low fluorescence background.
- Good stability of fluorophor.
- Useful for research purposes.
Medchemexpress LLC Apelin-16, human, bovine acetate | 99.8% | 2010.37 | 10 MG
Apelin-16, human, bovine acetate is a biologically active peptide that acts as the endogenous ligand for the G-protein-coupled APJ receptor. It is produced as a pre-proprotein of 77 amino acids, with Apelin-16 being one of its active fragments. This product is for research use only.
- White to off-white solid appearance
- Molecular weight of 2010.37 (free base)
- Purity of 99.77%
- Sequence: Phe-Arg-Arg-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe
- Soluble in DMSO at 100 mg/mL
Medchemexpress LLC NBD-556 | 333353-44-9 | 99.6% | C17H24ClN3O2 | 50 MG
NBD-556 is a CD4 mimetic and a potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction. It demonstrates potent cell fusion and virus-cell fusion inhibitory activity at low micromolar levels.
- Functions as a CD4 mimetic
- Potent HIV-1 entry inhibitor
- Blocks gp120-CD4 interaction
- Inhibits HIV-1 envelope-mediated virus-cell and cell-cell fusion
- Inhibits infection of MT-2 cells by laboratory-adapted HIV-1 strains
- Inhibits CD4-dependent virus in a dose-dependent manner
Apexbio Technology LLC NBD-Cl 10199-89-0 500mg
NBD-Cl (10199-89-0) is a fluorescent labeling reagent that covalently reacts with nucleophilic groups specifically amines and thiols It is designed to derivatize these functional groups enabling detection through the formation of highly fluorescent conjugates NBD-Cl exerts its biological utility primarily through its electrophilic reaction mechanism with free amino and thiol groups in biomolecules No specific experimental model or quantitative activity metric is provided Based on these chemical properties NBD-Cl holds research potential in the labeling and detection of amino acid residues peptides proteins and thiol-containing enzymes as well as in studies of enzyme activities and biomolecular interactions
Accela Chembio Inc 4-methyl-2 | 1 | 3-benzoxadiazole | 5g | 29091-40-5 | MFCD00100600 | 97+% | Shelf Life: 1440 Days | Light Sensitive/+4
4-methyl-2 | 1 | 3-benzoxadiazole | 5g | 29091-40-5 | MFCD00100600 | 97+% | Shelf Life: 1440 Days | Light Sensitive/+4
