Benzoxadiazoles
Medchemexpress LLC NBD-557 | 333352-59-3 | 99.4% | C17H24BrN3O2 | 25 MG
NBD-557 is a small molecule organic compound identified as a potential HIV-1 inhibitor. It targets viral entry by inhibiting the binding of HIV-1 envelope glycoprotein gp120 to the CD4 receptor without affecting later stages of the HIV-1 life cycle.
- Exhibits potent cell fusion and virus-cell fusion inhibitory activity at low micromolar levels.
- Active against X4 and R5 viruses, and laboratory-adapted HIV-1 strains, including an AZT-resistant strain.
- Binds to unliganded HIV-1 gp120, but not to the cellular receptor CD4.
Medchemexpress LLC NBD-PE | 178119-00-1 | 99.9% | 956.24 | 5 MG
NBD-PE is an effective lipid fluorescent probe with Excitation/Emission at 465/535 nm and a green color. It has wide applications in membrane and cell biology.
- Effective lipid fluorescent probe
- Excitation/emission: 465/535 nm
- Color: green
- Wide array of applications in membrane and cell biology
Medchemexpress LLC 3-C12-NBD-cholesterol | 1246303-05-8 | 99.9% | 747.06 | 1 MG
3-C12-NBD-cholesterol is a fluorescent cholesterol analog used for measuring membrane and intracellular trafficking dynamics. This product is a colorless to light yellow liquid with a purity of 99.9%.
- Fluorescent cholesterol analog
- Measures membrane and intracellular trafficking dynamics
- High purity of 99.9%
- Suitable for cell staining analysis
- Used as an organelle dye
- Used as a lipid droplet dye
- Solution storage at -20°C for up to 2 years
Medchemexpress LLC TNF-alpha/TNFSF2 Bo 10ug
Tumour Necrosis Factor alpha (TNF alpha) is a potent pro-inflammatory cytokine[1] TNF alpha binds to its receptors mainly TNFR1 and TNFR2 and then transmits molecular signals for biological functions such as inflammation and cell death[2] TNF alpha stimulates NF- B pathway via TNFR2 promotes cancer growth invasion and metastasis Anti-TNF- MAb significantly suppresses the tumor development in colitis-associated cancer (CAC) mouse[3] TNF alpha as a proneurogenic factor activates the SAPK/JNK Pathway and can facilitate neuronal replacement and brain repair in response to brain injury[4] TNF-alpha/TNFSF2 Protein Bovine is produced in E coli
Medchemexpress LLC NBD-14189 | 2234273-72-2 | 99.8% | C18H16F4N4O2S | 10MG
NBD-14189 is a small-molecule HIV-1 entry antagonist that binds the viral gp120 envelope protein and blocks virus entry. It shows potent activity in cell-based assays (IC50 ≈ 89 nM against HIV-1 HXB2 pseudovirus; antiviral EC50 <200 nM) and is supplied as a high-purity research compound for in vitro studies.
- Potent gp120-directed entry antagonist with IC50 ≈ 89 nM.
- Demonstrated antiviral activity in cell assays (EC50 <200 nM).
- High purity suitable for research use (≈99.8%).
- Supplied as solid and as 10 mM solution in DMSO for screening.
- Molecular formula C18H16F4N4O2S and molecular weight 428.40 g·mol⁻1.
- Recommended storage: 4°C sealed; in solvent store at -80°C for long term.
Medchemexpress LLC NBD-Pen | 1955505-54-0 | 99.9% | 390.46 | C19H28N5O4 | 5 MG
NBD-Pen is a turn-on fluorescent probe for selective detection of lipid-derived radicals in biological systems. It enables live-cell imaging and biochemical studies of lipid peroxidation and oxidative stress with sensitive fluorescence readout.
- High selectivity and sensitivity for lipid radicals.
- Turn-on fluorescence enables low-background detection in cells.
- Excitation at 470 nm and emission at 530 nm for standard imaging.
- High purity (99.94%) suitable for research use.
- Soluble in DMSO (100 mg/mL); ultrasonic assistance recommended.
- Store protected from light; follow solvent storage guidelines.
Medchemexpress LLC NBD-Pen | 1955505-54-0 | 99.9% | 50 MG
NBD-Pen is a fluorescent probe designed for the selective and sensitive detection of lipid radicals in biological systems. It functions by turn-on fluorescence to directly detect lipid radicals in living cells.
- First fluorescence probe for lipid radicals
- Offers high selectivity and sensitivity (λex: 470 nm, λem: 530 nm)
- Specifically detects lipid-derived radicals over other reactive species (e.g., H2O2, ClO-, O2-?, and ?OH)
- Directly detects lipid radicals in living cells through turn-on fluorescence
- Decreases inflammation, apoptosis, and oxidative stress markers
- Applicable in various disease models such as hepatic carcinoma