Benzoxadiazoles
Medchemexpress LLC Apelin-16, human, bovine acetate | 99.8% | 2010.37 | 1 MG
Apelin-16, human, bovine acetate is a biologically active peptide.
- Endogenous ligand for the G-protein-coupled APJ receptor.
- Produced as a pre-proprotein of 77 amino acids.
- One of the active fragments of Apelin.
Medchemexpress LLC Apelin-16, human, bovine acetate | 99.8% | 2010.37 (free base) | 5 MG
Apelin-16, human, bovine acetate is a biologically active peptide. Apelin is the endogenous ligand for the G-protein-coupled APJ receptor. It is produced as a pre-proprotein of 77 amino acids, and Apelin-16 is one of its active fragments.
- Biologically active peptide
- Endogenous ligand for the G-protein-coupled APJ receptor
- Derived from a pre-proprotein of 77 amino acids
- Active fragment of Apelin
Medchemexpress LLC NBD-556 | 333353-44-9 | 99.6% | C17H24ClN3O2 | 25 MG
NBD-556 is a CD4 mimetic and a potent HIV-1 entry inhibitor. It functions by blocking the gp120-CD4 interaction. NBD-556 exhibits potent cell fusion and virus-cell fusion inhibitory activity at low micromolar levels.
- Inhibits HIV-1 envelope-mediated virus-cell and cell-cell fusion.
- Inhibits the infection of MT-2 cells by laboratory-adapted HIV-1 strains.
- Inhibits CD4-dependent virus in a dose-dependent manner.
Medchemexpress LLC 4-(Aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole | 91366-65-3 | 98.75% | 50 MG
4-(Aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole | 91366-65-3 | 98.75% | 50 MG
Medchemexpress LLC 6α-ethyl-3α,7α,23-trihydroxy-24-nor-5β-cholan-23-sulfate | 1000403-03-1 | >98.0% | 494.66 g·mol⁻1 | C25H43NaO6S | 50MG
INT-767 is a synthetic dual agonist of the farnesoid X receptor (FXR) and the G protein-coupled bile acid receptor TGR5 (GPBAR1), used as a research reagent in preclinical studies of liver and metabolic disease. Reported activity includes mean EC50s of 30 nM (FXR) and 630 nM (TGR5); CAS 1000403-03-1; molecular formula C25H43NaO6S; molecular weight 494.66 g·mol⁻1. Typical supplier-reported purity is >98%. Material is for research use only and not for human therapeutic use.
- Dual FXR and TGR5 agonist for bile-acid signaling studies.
- Well-characterized potency: EC50 30 nM (FXR) and 630 nM (TGR5).
- High reported purity suitable for in vitro and in vivo experiments.
- Supplied as the sodium-sulfate derivative with defined molecular weight.
- Widely used in preclinical models of liver injury, steatosis, and metabolic regulation.
- For research use only; not for clinical or human use.
Sigma Aldrich Fine Chemicals Biosciences 7-Fluorobenzofurazan-4-sulfonic acid ammonium salt for HPLC derivatization, LiChropur(TM), >=98.5% (HPLC) | 84806-27-9 | MFCD02682109 | 25MG
7-Fluorobenzofurazan-4-sulfonic acid ammonium salt for HPLC derivatization, LiChropur(TM), >=98.5% (HPLC) | Purity: >=98.5% (HPLC) | Mol Wt: 235.19 | 84806-27-9 | MFCD02682109 | 25MG
Medchemexpress LLC Nbd-14270 | 2411819-82-2 | 99.5% | 425.43 | 100 MG
NBD-14270, a pyridine analogue, is a potent HIV-1 entry antagonist. It binds to HIV-1 gp120 and shows potent antiviral activity.
- Potent HIV-1 entry antagonist with an IC50 of 180 nM against 50 HIV-1 Env-pseudotyped viruses.
- Binds to HIV-1 gp120.
- Low cytotoxicity (CC50>100 μM).
- Anti-HIV-1 activity (IC50=0.16 μM) and Cytotoxicity (CC50=109.3 μM) in single-cycle (TZM-bl Cells) assay.
- Does not induce toxicity in the U87-CD4-CXCR4 cell line at doses used for assay.
Medchemexpress LLC Ganglioside GQ1b (bovine) sodium | 68652-37-9 | >98.0% | 2,528.55 g/mol | C106H182N6O56·4Na | 100ug
Ganglioside GQ1b (bovine) sodium promotes neurite outgrowth during early neuronal differentiation Ganglioside GQ1b (bovine) sodium controls the neuronal differentiation process in mESCs[1]
Medchemexpress LLC 25-NBD Cholesterol | 105539-27-3 | 99.0% | 564.76 | 1 MG
25-NBD Cholesterol is a fluorescently labeled form of cholesterol that facilitates the distinction between exogenous and endogenous cholesterol within bacterial cell membranes, emitting green fluorescence signals.
- Fluorescently labeled form of cholesterol.
- Facilitates distinction between exogenous and endogenous cholesterol within bacterial cell membranes.
- Emits green fluorescence signals.
Apexbio Technology LLC NBD-Cl 10199-89-0 1g
NBD-Cl (10199-89-0) is a fluorescent labeling reagent that covalently reacts with nucleophilic groups specifically amines and thiols It is designed to derivatize these functional groups enabling detection through the formation of highly fluorescent conjugates NBD-Cl exerts its biological utility primarily through its electrophilic reaction mechanism with free amino and thiol groups in biomolecules No specific experimental model or quantitative activity metric is provided Based on these chemical properties NBD-Cl holds research potential in the labeling and detection of amino acid residues peptides proteins and thiol-containing enzymes as well as in studies of enzyme activities and biomolecular interactions
Medchemexpress LLC Nbd-556 | 333353-44-9 | 99.6% | C17H24ClN3O2 | 1 ML
NBD-556, a CD4 mimetic, is a potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction. It demonstrates potent cell fusion and virus-cell fusion inhibitory activity at low micromolar levels.
- Potent HIV-1 entry inhibitor
- Blocks gp120-CD4 interaction
- Shows potent cell fusion and virus-cell fusion inhibitory activity
- Inhibits HIV-1 envelope-mediated virus-cell and cell-cell fusion
- Inhibits infection of MT-2 cells by laboratory-adapted HIV-1 strains
- Inhibits CD4-dependent virus in a dose-dependent manner
Medchemexpress LLC NBD-14270 | 2411819-82-2 | 99.53% | 425.43 | 1 ML
NBD-14270, a pyridine analogue, is a potent HIV-1 entry antagonist with an IC50 of 180 nM against 50 HIV-1 Env-pseudotyped viruses. It binds to HIV-1 gp120 and demonstrates potent antiviral activity, with low cytotoxicity (CC50>100 μM).
- Potent HIV-1 entry antagonist
- IC50 of 180 nM against 50 HIV-1 Env-pseudotyped viruses
- Binds to HIV-1 gp120
- Demonstrates potent antiviral activity
- Low cytotoxicity (CC50>100 μM)
Medchemexpress LLC Nbd-amine | 10199-91-4 | 96.7% | 100 MG
NBD-amine is a fluorogenic amine that fluoresces weakly in water and strongly in organic solvents, membranes, and other hydrophobic environments. It is used as an environment-sensitive fluorescent probe and labeling reagent in biochemical and biophysical research.
- Fluorogenic amine that increases fluorescence in nonpolar environments.
- Useful as a fluorescent probe and labeling reagent for biomolecules.
- Soluble in DMSO for preparation of concentrated stock solutions.
- Available in multiple pack sizes, including 100 mg.
- Supplied with reported purity suitable for research applications.
Medchemexpress LLC 6alpha-ethyl-3alpha,7alpha,23-trihydroxy-24-nor-5beta-cholan-23-sulfate sodium salt | 1000403-03-1 | 99.8% | 494.66 g/mol | C25H43NaO6S | 10MM 1ML
INT-767 is a research-grade dual farnesoid X receptor (FXR) and TGR5 agonist with reported mean EC50 values of 30 nM (FXR) and 630 nM (TGR5). It is supplied as a white to off-white solid and is available as a 10 mM solution in DMSO. Molecular formula C25H43NaO6S; molecular weight 494.66 g/mol. Intended for laboratory research use only.
- Potent dual FXR and TGR5 agonist with EC50s of 30 nM and 630 nM, respectively.
- High purity suitable for research applications.
- Available as solid or 10 mM DMSO solution for convenience.
- Highly soluble in DMSO and water according to manufacturer data.
- Stable under recommended storage: solid at 4°C; in solution at -80°C for long-term storage.
- Used in studies of bile acid signaling, metabolic disease, and liver injury models.