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Benzoxadiazoles

Organic heterocyclic compounds that consist of benzene fused with an oxadiazole; oxadiazoles are a five-membered ring with two carbon atoms, one oxygen atom, and two nitrogen atoms.

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Medchemexpress LLC NBD-14189 | 2234273-72-2 | 99.8% | 428.40 | C18H16F4N4O2S | 5 MG
SDP

NBD-14189 is a small-molecule HIV-1 entry antagonist that binds the viral gp120 protein and exhibits potent antiviral activity in cell-based assays. It is provided as a high-purity research reagent available as solids and as a DMSO solution, with characterized activity in single- and multi-cycle assays.

  • Binds HIV-1 gp120 to inhibit viral entry.
  • Potent antiviral activity (IC50 ≈ 89 nM; EC50 <200 nM).
  • Characterized in single-cycle (0.089 μM) and multi-cycle (0.18 μM) assays.
  • Available as solid quantities and as a 10 mM solution in DMSO.
  • High purity (99.84%) suitable for research use.
  • Storage recommendations provided for solids and solutions.

ENCOMPASS_PREFERRED
2

Medchemexpress LLC 1H-Pyrrole-2-carboxamide, N-[(1S)-2-amino-1-[4-(hydroxymethyl)-2-thiazolyl]ethyl]-5-[3-fluoro-4-(trifluoromethyl)phenyl]- | 2234273-72-2 | 99.8% | 428.40 | 1 ML
SDP

NBD-14189 is a potent HIV-1 entry antagonist with an IC50 of 89 nM against the HIV-1HXB2 pseudovirus. It binds to HIV-1 gp120 and demonstrates potent antiviral activity (EC50 < 200 nM). It is intended for research use only.

  • Potent HIV-1 entry antagonist
  • Binds to HIV-1 gp120
  • Shows potent antiviral activity (EC50<200 nM)
  • Anti-HIV-1 activity (IC50=0.089 μM) in single-cycle (TZM-bl cells) assays
  • Prevents HIV-1 mediated cell-cell fusion

ENCOMPASS_PREFERRED