Benzoxazines
AdipoGen Pimprinine
Chemical. CAS 13640-26-1. Formula C12H10N2O. MW 198.2. Isolated from Streptomyces sp. Indole alkaloid. Monoamine oxidase inhibitor MAOI. Antiepileptic anticonvulsant compound. Inhibitor of platelet aggregation and thromboxane A2 synthesis. Weak antifungal and antituberculosis activity. Useful as lead structure for potent antifungal substances.
AdipoGen Pimprinine
Chemical. CAS 13640-26-1. Formula C12H10N2O. MW 198.2. Isolated from Streptomyces sp. Indole alkaloid. Monoamine oxidase inhibitor MAOI. Antiepileptic anticonvulsant compound. Inhibitor of platelet aggregation and thromboxane A2 synthesis. Weak antifungal and antituberculosis activity. Useful as lead structure for potent antifungal substances.
TARGETMOL CHEMICALS INC TELOMERASE-IN-1 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Telomerase-IN-1 is a telomerase inhibitor (IC50 0.19 uM). telomerase-IN-1 activates hTERT expression through the endoplasmic reticulum stress (ERS) of the ER overreaction (EOR) which then induces ERS leading to apoptosis. telomerase-IN-1 leads to inhibition of cell proliferation through the expression of downstream signaling molecules including Telomease-IN-1 has high inhibitory activity against telomerase high anti-proliferative capacity against SMMC-7721 cells and no significant toxic effect on human normal hepatocytes. telomerase-IN-1 in xenograft tumor model exhibited antitumor activity. purity: 97%
TARGETMOL CHEMICALS INC PHOX-I2 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Phox-I2 is an NOX2-specific inhibitor. Phox-I2 reverts ROS-accumulation and leads to refusion of mitochondrial networks. purity: 99%
TARGETMOL CHEMICALS INC MX69 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. MX69 is the MDM2/XIAP inhibitor blocking the MDM2 protein-XIAP RNA interaction leading to MDM2 degradation. purity: 99%
TARGETMOL CHEMICALS INC PF07104091 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. PF07104091 inhibits CDK2 which may lead to cell cycle arrest induce apoptosis and inhibit tumor cell proliferation. purity: 98%
TARGETMOL CHEMICALS INC MP07-66 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. MP07-66 is a novel FTY720-analog devoid of immunosuppressive effects leads to the reactivation of PP2A which in turn triggers apoptosis of CLL cells. purity: 97%
TARGETMOL CHEMICALS INC BTSA1 10MG
Also available in 2 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. BTSA1 is a BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis. purity: 99%
TARGETMOL CHEMICALS INC DCBP-1 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. dCBP-1 is a chemical degrader of p300/CBP. dCBP-1 hijacks the E3 ubiquitin ligase CRBN for selective degradation of p300/CBP. Degradation of p300/CBP by dCBP-1 leads to effective multiple myeloma cell killing. purity: 98%
TARGETMOL CHEMICALS INC WM-3835 10MG
Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. WM-3835 is a novel and high-specific small molecule inhibitor of Lysine Acetyltransferase 7 (KAT7 MYST2 HBO1) able to potently suppressed OS cell proliferation and migration and leads to apoptosis activation. purity: 97%
TARGETMOL CHEMICALS INC NLRP3-IN-10 5MG
Also available in 10 mg 25 mg 50 mg 100 mg 200 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. NLRP3-IN-10 (ZVN26391) is a potent NLRP3 inhibitor. NLRP3-IN-10 inhibits IL-1(beta) release with an IC50 value of 251.1 nM. NLRP3-IN-10 attenuates ASC speck formation leading to suppress activation of NLRP3 inflammasome. purity: 99%
AdipoGen Umbellulone
Chemical. CAS 546-78-1. Formula C10H14O. MW 150.2. Isolated from Umbellularia californica Nutt. Offensive principle of the so-called "headache tree". Causes a painful cold sensation. Selective TRPA1 activator. Weak TRPM8 activator. Releases CGRP calcitonin gene-related peptide after TRPA1 activation which leads to activation of trigeminovascular pathways and CGRP-mediated neurogenic vasodilatation relevant to produce headache/migraine.
AdipoGen Umbellulone
Chemical. CAS 546-78-1. Formula C10H14O. MW 150.2. Isolated from Umbellularia californica Nutt. Offensive principle of the so-called "headache tree". Causes a painful cold sensation. Selective TRPA1 activator. Weak TRPM8 activator. Releases CGRP calcitonin gene-related peptide after TRPA1 activation which leads to activation of trigeminovascular pathways and CGRP-mediated neurogenic vasodilatation relevant to produce headache/migraine.
TARGETMOL CHEMICALS INC TRIPARANOL 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Triparanol (NSC-65345) interferes with posttranslational modification of Hedgehog signaling molecules as well as the sterol sensing domain of its receptor PTCH1 leading to down-regulation of Hedgehog signaling. Triparanol suppresses human tumor growth and is an antilipemic agent with high ophthalmic toxicity. purity: 99%
TARGETMOL CHEMICALS INC FIVE1 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. FiVe1 is a vimentin binding small molecule that promotes the disintegration and phosphorylation of vimentin in the metaphase leading to mitotic disasters polynuclearization and loss of cancer cell dryness. FiVe1 selectively and irreversibly inhibit the growth of mesenchymal transformed breast cancer cells (FOXC2-HMLER cell IC50=234nM) and soft tissue sarcomas of different histological subtypes. purity: 98%
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