Benzoxazines
TARGETMOL CHEMICALS INC FIVE1 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. FiVe1 is a vimentin binding small molecule that promotes the disintegration and phosphorylation of vimentin in the metaphase leading to mitotic disasters polynuclearization and loss of cancer cell dryness. FiVe1 selectively and irreversibly inhibit the growth of mesenchymal transformed breast cancer cells (FOXC2-HMLER cell IC50=234nM) and soft tissue sarcomas of different histological subtypes. purity: 98%
Medchemexpress LLC Gallocyanine (chloride) | 1562-85-2 | 92.0% | 25 MG
Gallocyanine chloride is a synthetic blue dyestuff being investigated as a potential agent for Alzheimer's disease and related neurodegenerative tauopathies. It functions by inhibiting DKK1/LRP6 interaction with an IC50 of 6.38 μM, which in turn activates the Wnt signaling pathway and leads to β-catenin accumulation. This compound also demonstrates anti-metastasis, anti-inflammatory, and anti-fibrosis activities. Additionally, Gallocyanine chloride can be employed as a fluorescent probe for detecting superoxide anion radicals.
- Potential research agent for Alzheimer's disease and neurodegenerative tauopathies
- Inhibits DKK1/LRP6 interaction
- Activates Wnt signaling pathway
- Causes β-catenin accumulation
- Exhibits anti-metastasis activity
- Exhibits anti-inflammatory activity
- Exhibits anti-fibrosis activity
- Can be used as a fluorescent probe for superoxide anion radical detection