Biotin and derivatives
Medchemexpress LLC Bis-SS-C3-NHS ester | 98604-88-7 | 98.0% | 432.47 | C16H20N2O8S2 | 1 G
Bis-SS-C3-NHS ester is a disulfide-cleavable N-hydroxysuccinimide (NHS) ester linker used for bioconjugation and antibody-drug conjugate (ADC) synthesis. It couples to primary amines via NHS-ester chemistry and releases payloads under reducing intracellular conditions.
- Molecular weight: 432.47
- Chemical formula: C16H20N2O8S2
- Cas number: 98604-88-7
- Purity: 98.0%
- Appearance: white to off-white solid
- Reactive group: NHS ester for coupling to primary amines
- Application: cleavable disulfide linker for ADC synthesis and bioconjugation
- Available pack size: 1 g
Medchemexpress LLC Bcn-ss-nhs | 95.0% | 454.56 g/mol | C20H26N2O6S2 | 25 MG
BCN-SS-NHS is a cleavable antibody-drug conjugate (ADC) linker and click-chemistry reagent containing a bicyclo[6.1.0]nonyne (BCN) group and an N-hydroxysuccinimide (NHS) ester for conjugation. It is used for bioconjugation and ADC synthesis, enabling copper-free strain-promoted alkyne-azide cycloaddition (SPAAC) and disulfide-based release in reducing environments.
- Cleavable disulfide linker for intracellular release
- N-hydroxysuccinimide ester for efficient amine coupling
- BCN moiety enables copper-free click chemistry (SPAAC)
- High purity suitable for conjugation (95.0% by NMR)
- Molecular weight 454.56 g/mol; formula C20H26N2O6S2
Medchemexpress LLC DOTA-NHS-ester | 170908-81-3 | MFCD23381190 | ≥97.0% | 501.49 | C20H31N5O10 | 5 G
DOTA-NHS-ester is an N-hydroxysuccinimide ester derivative of the DOTA chelator used to conjugate amine-containing molecules for radiolabeling and imaging probe development. It is supplied as a solid and is handled and stored under low-temperature, moisture-free conditions.
- Used to conjugate DOTA to primary amines for PET and SPECT probe development.
- High purity suitable for research applications.
- Soluble in DMSO at 50 mg/mL; protocols provided for aqueous in vivo formulations.
- Stable as a solid when stored sealed at -20 °C; dissolved samples have recommended cold storage times.
- Molecular weight 501.49 and CAS number 170908-81-3 for unambiguous identification.
Medchemexpress LLC AF647-NHS ester (triTEA) | 407627-61-6 | 99.7% | 10 MG
AF647-NHS ester (triTEA) is a far-red fluorescent NHS ester reagent used to label primary amines for fluorescence detection. Supplied as a purple solid, it is optimized for conventional and instantaneous detection and is soluble in DMSO when warmed or sonicated.
- Far-red fluorescent NHS ester for amine conjugation.
- Excitation: 635 nm (conventional) / 620 nm (instantaneous).
- Physical form: purple to dark purple solid.
- Purity: 99.74% as reported by manufacturer.
- Solubility: DMSO 20 mg/mL; use freshly opened DMSO and apply ultrasonic/heat to 60°C as needed.
- Storage: protect from light and store under nitrogen; in solvent: -80°C (6 months), -20°C (1 month).
- For research use only; not for patient use.
Medchemexpress LLC Biotin-PEG1-azide | 1204085-48-2 | 99.9% | 356.44 | C14H24N6O3S | 25 MG
Biotin-PEG1-azide is a biotinylated, single-unit polyethylene glycol (PEG) linker terminating in an azide functional group. It is used for bioconjugation and antibody-drug conjugate (ADC) synthesis through click chemistry reactions (CuAAC and SPAAC).
- Cleavable single-unit PEG linker for controlled spacing and solubility.
- Azide functional group enables CuAAC with alkynes and strain-promoted cycloaddition with DBCO/BCN.
- Suitable for ADC synthesis, protein labeling, and bioconjugation workflows.
- High purity (99.9%), characterized by H NMR, RP-HPLC, and MS.
- Available in small-scale packs for research use (e.g., 25 mg).
Medchemexpress LLC m-PEG8-NHS ester | 756525-90-3 | MFCD13184969 | 95.0% | 509.54 g/mol | C22H39NO12 | 100 MG
m-PEG8-NHS ester is a methoxy polyethylene glycol (PEG) linker containing an N-hydroxysuccinimide (NHS) ester functional group. It provides an eight-unit PEG spacer for conjugation to primary amines and is used in antibody-drug conjugate (ADC) synthesis and general bioconjugation to increase solubility and reduce aggregation.
- Non-cleavable 8-unit PEG spacer
- Amine-reactive NHS ester for conjugation
- Supplied as a 100 mg vial (research use only)
- Purity by NMR: 95.0%
- Molecular weight 509.54 g/mol; formula C22H39NO12
- Store pure material at -20°C for long-term stability
Medchemexpress LLC Bis-PEG13-NHS ester | 2221949-00-2 | 98.0% | 884.92 g/mol | C38H64N2O21 | 25 MG
Bis-PEG13-NHS ester is a PEG-based N-hydroxysuccinimide (NHS) ester linker for research use in the synthesis of antibody-drug conjugates (ADCs) and proteolysis targeting chimeras (PROTACs).
- Provides a bifunctional PEG13 spacer for conjugation to amines.
- Reactive NHS ester termini enable efficient coupling.
- High purity suitable for research applications.
- Molecular weight approximately 884.92 g/mol; molecular formula C38H64N2O21.
- Available in small pack sizes for research-scale synthesis.
Medchemexpress LLC (S,E)-TCO-NHS ester | 1610931-22-0 | MFCD24386372 | ≥98.0% | 267.28 g/mol | C13H17NO5 | 10 MG
TCO-NHS ester (axial) is a trans-cyclooctene N-hydroxysuccinimide ester used as an amine-reactive building block for bioorthogonal conjugation. It enables rapid inverse electron-demand Diels-Alder (iEDDA) reactions with tetrazine partners and is suitable for labeling or modifying amine-containing small molecules and biomolecules in organic media. The reagent is supplied as a purified solid with supporting analytical documentation for research use.
- Amine-reactive NHS ester for efficient conjugation.
- Fast bioorthogonal iEDDA reactivity with tetrazines.
- Suitable for labeling and bioconjugation of biomolecules.
- High purity for reproducible experimental results.
- Analytical documentation available (SDS, COA, H-NMR).
Medchemexpress LLC IL-13 Human Biotin 100ug
IL-13 protein is a cytokine involved in allergic inflammation immune response to parasites and B cell proliferation IL-13 Protein Human (Biotinylated HEK293 Avi-His) is the recombinant human-derived IL-13 protein expressed by HEK293 with C-Avi C-6 His labeled tag