Biotin and derivatives
Apexbio Technology LLC Biotin Hydrazide 66640-86-6 500mg
Biotin hydrazide is a hydrazide-functionalized biotin derivative designed to selectively label and detect protein carbonylation an irreversible post-translational modification frequently arising from oxidative stress conditions Protein carbonylation typically results from reactions between protein side chains and reactive oxygen species (ROS) lipid peroxidation metabolites such as -unsaturated -hydroxyalkenals or glycation-mediated oxidative modifications Mechanistically Biotin Hydrazide interacts specifically with protein-bound carbonyl groups through hydrazone formation under mildly acidic conditions (around pH 5 5) without the requirement of additional reducing agents or catalysts Thus Biotin hydrazide facilitates biochemical studies aimed at identifying and characterizing carbonyl-modified proteins in biological samples through biotin-based detection assays and downstream proteomic analysis techniques
Medchemexpress LLC DOTA-NHS-ester | 170908-81-3 | 501.49 g/mol | C20H31N5O10 | 1 G
DOTA-NHS-ester is an amine-reactive DOTA derivative (N-hydroxysuccinimide ester) used to conjugate chelators to peptides, proteins, and other biomolecules for radiolabeling and imaging probe preparation in PET and SPECT studies. It has formula C20H31N5O10 and molecular weight 501.49 g/mol. Manufacturer documents such as a datasheet, SDS, and COA are available.
- Amine-reactive NHS-ester for conjugation.
- Suitable for radiolabeling and imaging probe preparation.
- Chelator compatible with common radiometals.
- Molecular weight 501.49 g/mol.
- CAS number 170908-81-3.
- Supplied in research pack sizes including 1 g.
Medchemexpress LLC Nsp-dmae-nhs | 194357-64-7 | 99.5% | 1 MG
NSP-DMAE-NHS is an acridinium ester chemiluminescence reagent containing an N-sulfopropyl group. It is useful in the clinical diagnostics industry, especially in automated immunochemistry analyzers. The product is for research use only and not sold to patients.
- Acridinium ester chemiluminescence reagent
- Contains n-sulfopropyl group
- Useful in the clinical diagnostics industry
- Applicable in automated immunochemistry analyzers
Sigma Aldrich Fine Chemicals Biosciences Biotin disulfide N-hydroxysuccinimide ester >98%, powder | Purity: >98% | Mol Wt: 575.72 | 142439-92-7 | MFCD00466919 | 100MG
Biotin disulfide N-hydroxysuccinimide ester >98%, powder | Purity: >98% | Mol Wt: 575.72 | 142439-92-7 | MFCD00466919 | 100MG
Medchemexpress LLC Azido-PEG3-NHS ester | 1092654-47-1 | ≥98.0% | C12H18N4O7 | 250 MG
Azido-PEG3-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, capable of participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules, and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. This compound is integral in the development of PROTACs, which harness the ubiquitin-proteasome system to selectively degrade target proteins.
- Peg-based protac linker
- Used in the synthesis of protacs
- Click chemistry reagent
- Contains an azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Engages in strain-promoted alkyne-azide cycloaddition (SPAAC)
- Enables selective degradation of target proteins
Medchemexpress LLC Fluorescein biotin | 134759-22-1 | MFCD00132986 | ≥90.0% | 831.01 | C42H50N6O8S2 | 10 MG
Fluorescein biotin is a fluorescently labeled biotin conjugate used as a non-radioactive alternative to radioactive biotin for detecting and quantitating biotin-binding sites by fluorescence or absorbance. It is supplied as a dry powder; solutions are unstable and should be prepared fresh and protected from light.
- Used for fluorescent detection and quantitation of biotin-binding sites.
- Fluorescence or absorbance is quenched upon binding to avidin or streptavidin.
- Supplied as a dry powder; prepare fresh solutions because it is unstable in solution.
- Store at 4°C and protect from light to preserve activity.
- Typical excitation ~485 nm and emission ~535 nm.
Medchemexpress LLC Sulfo-NHS-Acetate sodium | 221222-61-3 | 95.0% | C6H6NNaO7S | 25 MG
Sulfo-NHS-Acetate sodium is an alkyl chain-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are molecules designed with two distinct ligands connected by a linker: one targeting an E3 ubiquitin ligase and the other a protein of interest. This mechanism exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Alkyl chain-based PROTAC linker
- Can be used in the synthesis of PROTACs
- Targets the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC MeCY5-NHS ester triethylamine | 00-00-0 | 96.2% | 777.94 g/mol | C36H40N3KO10S2 | 5 MG
MeCY5-NHS ester (potassium) is an amine-reactive Cy5-family fluorescent dye supplied as the NHS-ester potassium salt for labeling proteins, peptides, and nucleic acids in fluorescence assays and imaging.
- Reactive N-hydroxysuccinimide (NHS) ester for covalent labeling of primary amines.
- Cy5-family near-infrared fluorescence, approx. 649/670 nm excitation/emission.
- Potassium salt form with improved water solubility for aqueous labeling.
- Supplied with analytical documentation, including SDS, COA, 1H NMR, and LC-MS.
- Available in lab-scale quantities suitable for conjugation experiments.
Medchemexpress LLC Ovalbumin-Biotin | 98.0% | 1 ML
Ovalbumin-Biotin is a biotinylated biochemical reagent utilized in research to label or detect specific antigens, molecules, or cellular structures.
- Purity: 98.0%
- Appearance: Liquid
- Color: Colorless to light yellow
- Shipping: Room temperature in continental US; may vary elsewhere
- Storage: Store under recommended conditions in the Certificate of Analysis
Medchemexpress LLC NOTA-NHS ester | 1338231-09-6 | MFCD30747764 | 90.0% | 400.38 | C16H24N4O8 | 10 MG
NOTA-NHS ester is an N-hydroxysuccinimide (NHS) ester used to conjugate a NOTA chelator to biomolecules for subsequent fluorescent or radioactive nuclide labeling in research applications. It is supplied as a solid reagent with defined molecular characteristics for use in radiopharmaceutical and probe development.
- Provides an NHS-ester functional group for amine conjugation.
- Suitable for fluorescent labeling and radioactive nuclide labeling applications.
- Documented molecular formula C16H24N4O8 and molecular weight 400.38.
- Available in small research pack sizes for synthesis and probe preparation.
- Typically soluble in DMSO for conjugation reactions.
![Medchemexpress LLC 2,5-pyrrolidinedione, 1,1'-[oxybis[(1-oxo-3,1-propanediyl)oxy]]bis- (9CI) | 65869-64-9 | MFCD20226397 | 97.0% | 356.28 | C14H16N2O9 | 500 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000203008.png-250.jpg)
Medchemexpress LLC 2,5-pyrrolidinedione, 1,1'-[oxybis[(1-oxo-3,1-propanediyl)oxy]]bis- (9CI) | 65869-64-9 | MFCD20226397 | 97.0% | 356.28 | C14H16N2O9 | 500 MG
Bis-PEG1-NHS ester is a non-cleavable 1-unit polyethylene glycol (PEG) linker designed for antibody-agent conjugation (ADC) research applications. It contains two N-hydroxysuccinimide (NHS) ester reactive groups that enable conjugation to primary amines on proteins or payload molecules, and is supplied with high purity for analytical and synthetic workflows.
- Non-cleavable 1-unit PEG linker for antibody-agent conjugation.
- Contains two NHS ester reactive groups for conjugation to primary amines.
- Intended for research use in ADC linker synthesis and bioconjugation workflows.
- Purity 97.0% by HPLC.
- Available in a 500 MG pack size suitable for preparative work.
Apexbio Technology LLC Cy3 Bis NHS ester 25mg
Cy3 Bis NHS ester is a water-soluble fluorescent labeling reagent containing two amine-reactive NHS ester groups on a single dye molecule This compound specifically reacts with primary amines such as lysine residues on proteins or amine-modified nucleic acids enabling covalent fluorescent conjugation Upon formation of stable amide bonds with target molecules Cy3 fluorescence can be detected with standard fluorescence instruments exhibiting excitation at approximately 550 nm and emission near 570 nm Typical applications encompass labeling proteins peptides antibodies nucleic acids and other amine-containing biomolecules for fluorescence microscopy flow cytometry and biochemical assays as well as single-molecule fluorescence resonance energy transfer (FRET) studies
Apexbio Technology LLC Biotin-11-CTP 1ml (100 mM)
Biotin-11-CTP is a substrate for SP6 T3 and T7 RNA polymerases It can substitute CTP in RNA labeling reactions with biotin during in vitro transcription Biotin-labeled RNA probes can be detected using streptavidin conjugates and are widely utilized in many molecular biology applications such as in situ hybridization and gene expression microarrays
eMolecules Broadpharm Azidobutyric acid NHS ester 100mg 550804169 BP-22526 96 000 943858-70-6 MFCD22573606 226 192 C8H10N4O4
Broadpharm Azidobutyric acid NHS ester 100mg 550804169 BP-22526 96 000 943858-70-6 MFCD22573606 226 192 C8H10N4O4
Medchemexpress LLC DBCO-NHS ester 3 100mg | 1393350-27-0 | 416.43 | C24H20N2O5 | 100 MG
DBCO-NHS ester 3 is an amine-reactive dibenzocyclooctyne (DBCO)-based N-hydroxysuccinimide (NHS) ester used as a clickable linker for constructing antibody-drug conjugates and for labeling amine-containing biomolecules via strain-promoted alkyne-azide cycloaddition. Supplied as a 100 MG solid for research use.
- Amine-reactive NHS ester enables covalent coupling to primary amines.
- DBCO moiety supports copper-free click chemistry (SPAAC) with azides.
- Suitable for antibody-drug conjugate linker synthesis and protein labeling.
- Provided in small research-scale solid quantities for laboratory workflows.
- Molecular formula C24H20N2O5; molecular weight 416.43 g/mol.