Biotin and derivatives
Medchemexpress LLC FP-biotin | 259270-28-5 | 99.8% | C27H50FN4O5PS | 10MG
FP-Biotin is a biotinylated fluorophosphonate probe designed to covalently label serine hydrolases for activity-based profiling. The biotin tag enables enrichment and identification of labeled proteins or peptides from plasma and complex samples using avidin/streptavidin capture. Available as a solid and as a DMSO solution for flexible workflows.
- covalently labels serine hydrolases for activity profiling
- enables affinity purification via biotin-avidin interaction
- suitable for plasma and complex biological samples
- supplied as solid or ready-to-use solution for workflow flexibility
- high purity for reproducible results
- supported by data sheet, COA, and SDS for quality and safety
Medchemexpress LLC Biotin-PEG-amine (MW 2000) | 90.0% | 25 MG
Biotin-PEG-amine (MW 2000) is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. This product is intended for research purposes only and is not for patient use. PROTACs utilize two distinct ligands joined by a linker, one targeting an E3 ubiquitin ligase and the other targeting the protein of interest. This mechanism exploits the intracellular ubiquitin-proteasome system to facilitate the selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- For research use only
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
- Appearance: Solid
- Color: White to off-white
Medchemexpress LLC Alexa fluor 647 NHS ester | 1620475-28-6 | 95.0% | 942.06 g/mol | C39H47N3O16S4 | 10 MG
Alexa Fluor 647 NHS ester is a far-red, amine-reactive fluorescent dye (succinimidyl ester) used to covalently label primary amines on proteins, peptides, and amine-modified oligonucleotides for fluorescence imaging and flow cytometry.
- Far-red, bright, and photostable fluorescent dye suitable for imaging and flow cytometry.
- Amine-reactive NHS (succinimidyl) ester enables covalent labeling of primary amines.
- Compatible with proteins, peptides, and amine-modified oligonucleotides.
- High purity (95.0%) for reliable conjugation performance.
- Supplied as a solid; store sealed at -20°C, protected from moisture and light.
- COA, SDS, and handling documents available to support safe use and quality verification.
Medchemexpress LLC Bis-PEG13-NHS ester | 2221949-00-2 | 98.0% | 884.92 g/mol | C38H64N2O21 | 25 MG
Bis-PEG13-NHS ester is a PEG-based N-hydroxysuccinimide (NHS) ester linker for research use in the synthesis of antibody-drug conjugates (ADCs) and proteolysis targeting chimeras (PROTACs).
- Provides a bifunctional PEG13 spacer for conjugation to amines.
- Reactive NHS ester termini enable efficient coupling.
- High purity suitable for research applications.
- Molecular weight approximately 884.92 g/mol; molecular formula C38H64N2O21.
- Available in small pack sizes for research-scale synthesis.
Medchemexpress LLC DOTA-NHS-ester | 170908-81-3 | >97.0% | 501.49 g/mol | C20H31N5O10 | 250 MG
DOTA-NHS-ester is an NHS-activated DOTA chelator used to conjugate the DOTA moiety to biomolecules (for example, peptides, proteins, and affibodies) to enable radiolabeling for PET, SPECT, and radiotherapeutic research. It is supplied as a white to off-white solid with high purity and is soluble in DMSO.
- NHS-activated DOTA chelator for amine conjugation.
- High purity (>97.0%).
- Molecular weight 501.49 g/mol; formula C20H31N5O10.
- Soluble in DMSO (50 mg/mL); ultrasonic assistance recommended.
- Storage: sealed, away from moisture; in solvent -80°C (6 months) or -20°C (1 month).
- Intended for radiolabeling research (PET/SPECT); not for human use.
Medchemexpress LLC Biotin-PEG-Biotin | 194920-55-3 | 99.3% | C26H44N6O6S2 | 25 MG
Biotin-PEG-Biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
- PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Chem-Impex International, Inc. (+) Biotinyl-6-aminohexanoic acid | 72040-64-3 | MFCD00144853 | 250MG
(+) Biotinyl-6-aminohexanoic acid, 72040-64-3, MFCD00144853, 250MG
Medchemexpress LLC Biotin-PEG3-acid 100mg | 252881-76-8 | 100 MG
Biotin-PEG3-acid is a biotin-labeled polyethylene glycol (PEG3) linker containing a terminal carboxylic acid. It is supplied as a purified research-grade small molecule for use in PROTAC synthesis and biotinylation applications.
- Biotin-labeled PEG3 linker with terminal carboxylic acid.
- Designed for PROTAC synthesis and biotinylation workflows.
- High purity, 98.0%.
- Soluble in DMSO at 100 mg/mL; ultrasonic assistance recommended.
- Store sealed at 4°C; in solution store at -80°C for long-term stability.
- Available in 100 MG and larger pack sizes for research use.
Medchemexpress LLC PC biotin-PEG3-NHS ester | 2353409-93-3 | 840.89 | C36H52N6O15S | 10 MG
PC Biotin-PEG3-NHS ester is a cleavable 3-unit polyethylene glycol (PEG3) biotinylation reagent bearing an N-hydroxysuccinimide (NHS) active ester. It is used as a cleavable ADC linker and for biotinylation of primary amines in peptides, proteins, and other biomolecules to enable affinity capture or detection. The product is supplied as a solid and should be stored as a powder at -20°C; solutions have shorter storage lifetimes. Handle only by trained personnel for research use.
- Cleavable PEG3 biotin linker for ADC conjugation and labeling
- Reactive NHS ester for selective labeling of primary amines
- Molecular weight 840.89 and formula C36H52N6O15S
- Solid appearance; store powder at -20°C for long-term stability
- Intended for laboratory research use only
Medchemexpress LLC N-Mal-N-bis(PEG2-NHS ester) | 2182601-73-4 | 98.9% | C29H38N4O15 | 25 MG
N-Mal-N-bis(PEG2-NHS ester) is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs employ two distinct ligands connected by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets a specific protein. These compounds leverage the intracellular ubiquitin-proteasome system for selective degradation of target proteins. This product is for research use only.
- PEG-based PROTAC linker
- Supports synthesis of PROTACs
- Exploits ubiquitin-proteasome system
- Enables selective degradation of target proteins
- Store at -20°C, protected from light and under nitrogen
- Soluble in DMSO (100 mg/mL)
![eMolecules 2353409-89-7 | Azido-PEG11-[4-(5-(1-hydroxyethyl)-2-methoxy-4-nitrophenoxy)-butanamide] | Broadpharm851.945 | C37H65N5O17 | 96.000 | COc1cc(c(cc1OCCCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])C(C)O)[N+]([O-])=O | 100mg | 445408999](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502183507.JPG-250.jpg)
eMolecules 2353409-89-7 | Azido-PEG11-[4-(5-(1-hydroxyethyl)-2-methoxy-4-nitrophenoxy)-butanamide] | Broadpharm851.945 | C37H65N5O17 | 96.000 | COc1cc(c(cc1OCCCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])C(C)O)[N+]([O-])=O | 100mg | 445408999
Azido-PEG11-[4-(5-(1-hydroxyethyl)-2-methoxy-4-nitrophenoxy)-butanamide] | Broadpharm | 2353409-89-7851.945 | C37H65N5O17 | 96.000 | COc1cc(c(cc1OCCCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])C(C)O)[N+]([O-])=O | 100mg | 445408999
Medchemexpress LLC m-PEG14-NHS ester | 00-00-0 | 95.0% | C34H63NO18 | 10MG
m-PEG14-NHS ester is a methoxy-terminated polyethylene glycol (PEG) reagent bearing an N-hydroxysuccinimide (NHS) active ester. Supplied as a solid for laboratory use, it is intended for use as a PROTAC linker or for PEGylation to attach PEG chains to amine-containing molecules via stable amide bonds.
- Methoxy-terminated PEG with an NHS active ester.
- Reacts with primary amines to form stable amide bonds.
- Molecular weight ~773.86 Da.
- Chemical formula C34H63NO18.
- Purity ≥95.0%.
- White to off-white solid appearance.
- Store sealed, away from moisture and light; in solvent: -80°C for 6 months, -20°C for 1 month.
- Available in small research pack sizes.
Medchemexpress LLC m-PEG1-NHS ester 250mg | 1027371-75-0 | 201.18 g/mol | C8H11NO5 | 250 MG
m-PEG1-NHS ester is a PEG/alkyl/ether-based N-hydroxysuccinimide (NHS) ester linker used for assembling proteolysis targeting chimeras (PROTACs) and for amine-directed bioconjugation. Supplied as a solid, it provides a short PEG spacer with an activated ester for efficient coupling in synthetic workflows.
- PEG/alkyl/ether-based linker for PROTAC synthesis.
- N-hydroxysuccinimide ester reactive toward primary amines.
- Molecular weight 201.18 g/mol.
- Chemical formula C8H11NO5.
- Purity 95.0%.
- Appearance white to light yellow solid.
- Storage: powder -20°C (3 years); in solvent -80°C (6 months), -20°C (1 month).
- Available package size 250 MG.
Medchemexpress LLC Biotin-PEG11-amine | 1418022-42-0 | MFCD21363309 | 99.9% | C34H66N4O13S | 10MG
Biotin-PEG11-amine is a biotin-labeled polyethylene glycol linker with a terminal primary amine, supplied as a solid for research use. It is intended for biotinylation and incorporation into PROTACs or other conjugates, offering improved aqueous solubility and a flexible spacer to reduce steric hindrance during coupling reactions.
- Provides a terminal primary amine for coupling to carboxyl or phosphate groups.
- Contains an 11-unit PEG spacer to improve solubility and flexibility.
- Supports biotin-based affinity capture and detection workflows.
- Supplied as a white to off-white solid with high purity.
- Recommended storage: -20°C protected from light; in solvent, -80°C for long-term storage.