Biotin and derivatives
Medchemexpress LLC m-PEG-NHS ester | 92451-01-9 | MFCD06412227 | 98.0% | 2,000 Da | C9H13NO6 | 500 MG
m-PEG-NHS ester is a methoxy-terminated polyethylene glycol reagent functionalized with an N-hydroxysuccinimide (NHS) ester for selective conjugation to primary amines. With an average molecular weight of approximately 2,000 Da, it is used to introduce PEG chains that improve solubility, stability, and circulation time of proteins, peptides, and small molecules. Supplied as a 500 mg solid.
- Methoxy-terminated PEG with NHS ester reactive group.
- Average molecular weight ~2,000 Da for spacer and solubility enhancement.
- High purity suitable for bioconjugation (reported 98.0%).
- Reacts selectively with primary amines to form stable amide linkages.
- Commonly used for PEGylation, linker construction, and bioconjugation.
Medchemexpress LLC Mal-PEG3-C1-NHS ester | 2230016-26-7 | 95.0% | 384.34 g/mol | C16H20N2O9 | 50 MG
Mal-PEG3-C1-NHS ester is a non-cleavable 3-unit polyethylene glycol (PEG) linker bearing a maleimide and an N-hydroxysuccinimide (NHS) ester. It is supplied for research use to facilitate conjugation between amine and thiol groups during antibody-drug conjugate (ADC) synthesis, and is provided as a solution for low-temperature storage.
- Non-cleavable 3-unit polyethylene glycol linker.
- Terminal maleimide and NHS ester functional groups for thiol and amine coupling.
- Suitable for antibody-drug conjugate (ADC) synthesis.
- Purity approximately 95.0%.
- Supplied as a solution; store at -20°C for up to 2 years.
![eMolecules 21160-82-7 | Z-Lys(Z)-ONp | Combi-Blocks | MFCD00024657 | 535.553 | C28H29N3O8 | 97.000 | [O-][N+](=O)c1ccc(OC(=O)[C@H](CCCCNC(=O)OCc2ccccc2)NC(=O)OCc2ccccc2)cc1 | 1g | 357559919](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00128114-357559919.PNG-250.jpg)
eMolecules 21160-82-7 | Z-Lys(Z)-ONp | Combi-Blocks | MFCD00024657 | 535.553 | C28H29N3O8 | 97.000 | [O-][N+](=O)c1ccc(OC(=O)[C@H](CCCCNC(=O)OCc2ccccc2)NC(=O)OCc2ccccc2)cc1 | 1g | 357559919
Z-Lys(Z)-ONp | Combi-Blocks | 21160-82-7 | MFCD00024657 | 535.553 | C28H29N3O8 | 97.000 | [O-][N+](=O)c1ccc(OC(=O)[C@H](CCCCNC(=O)OCc2ccccc2)NC(=O)OCc2ccccc2)cc1 | 1g | 357559919
Medchemexpress LLC AMT-NHS | 2925268-86-4 | 98.7% | 443.47 g·mol⁻¹ | C22H21NO7S | 10 MG
AMT-NHS is an RNA-protein crosslinker that combines a psoralen intercalator with an N-hydroxysuccinimide (NHS) ester to covalently capture RNA-protein interactions. It is cell-permeable and has been used in living cells to map diverse RNA-protein contacts, producing distinct crosslinking patterns for single- and double-stranded RNA regions.
- Enables dual reactivity: psoralen-mediated photo-crosslinking of RNA and NHS-ester conjugation to protein amines.
- Cell-permeable for in vivo crosslinking applications.
- Soluble in DMSO at high concentration; may require warming and sonication to dissolve.
- High supplied purity supports reproducible crosslinking experiments.
- Stable as a powder under low-temperature storage; solution storage times are defined for sample handling.
Medchemexpress LLC Biotin-PEG7-maleimide | 1898221-65-2 | 99.4% | 745.88 g/mol | C33H55N5O12S | 25 MG
Biotin-PEG7-maleimide is a thiol-specific biotinylation reagent that introduces a biotin tag through a PEG7 spacer by reacting with free thiol (-SH) groups. It is used for selective cysteine labeling, affinity capture and detection, and for constructing drug-linker conjugates in bioconjugation workflows.
- Thiol-reactive maleimide group for selective cysteine labeling.
- PEG7 spacer provides flexibility and improved solubility.
- Biotin tag enables affinity capture and detection.
- High purity (99.4%) suitable for sensitive assays.
- Powder stable at -20°C for up to 3 years.
- Available as 25 MG quantity.
Medchemexpress LLC Biotin-PEG8-NHS ester | 2143968-03-8 | 99.89% | C33H56N4O14S | 50 MG
Biotin-PEG8-NHS ester is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs consist of two distinct ligands connected by a linker, where one ligand targets an E3 ubiquitin ligase and the other targets a specific protein. These molecules leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins. The product is intended for research use only.
- Utilized in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Intended for research use only
Sigma Aldrich Fine Chemicals Biosciences Biotin >=99% (HPLC), lyophilized powder | 58-85-5 | MFCD00005541 | 25G
Biotin >=99% (HPLC), lyophilized powder | Purity: >=99% (HPLC) | Mol Wt: 244.31 | 58-85-5 | MFCD00005541 | 25G
Medchemexpress LLC Azido-PEG5-NHS ester | 1433996-86-1 | ≥98.0% | C17H28N4O9 | 100 MG
Azido-PEG5-NHS ester is a PEG-based PROTAC linker primarily used in the synthesis of PROTACs. It acts as a versatile click chemistry reagent, incorporating an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. This compound also supports strain-promoted alkyne-azide cycloaddition (SPAAC) reactions when used with molecules containing DBCO or BCN groups. It is intended for research use only.
- PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc)
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
Apexbio Technology LLC DMG-PEG2000-NHS(Synonyms: DMG-PEG2000-NHS ester, NHS-PEG2000-DMG, DMG PEG NHS ester), 100mg.
DMG-PEG2000-NHS is a polyethylene glycol (PEG) derivative functionalized with an N-hydroxysuccinimide (NHS) ester The reactive NHS ester readily forms stable amide linkages upon interaction with primary amine (-NH ) groups facilitating covalent attachment to peptides proteins or amino-functionalized small molecules Due to these conjugation properties DMG-PEG2000-NHS is commonly employed in biomedical research for constructing drug delivery platforms such as lipid nanoparticles (LNPs) or liposomes particularly for siRNA delivery systems
Medchemexpress LLC Amino-PEG11-amine | 479200-82-3 | 95.0% | 100 MG
Amino-PEG11-amine is a PEG-based PROTAC linker designed to combine mono diethylstilbestrol (DES)-based ligands. This offers an alternative approach for creating more selective and active ER antagonists, useful in the endocrine treatment of breast cancer. The product appears as an oil with a white to off-white color. Its molecular weight is 544.68 and its formula is C24H52N2O11. This product is for research use only and not for sale to patients.
- PEG-based PROTAC linker
- Combines mono diethylstilbestrol (DES)-based ligands
- Supports development of selective ER antagonists
- Potential for breast cancer endocrine therapy
- Appears as an oil
- Color: white to off-white
- Molecular weight: 544.68
- Chemical formula: C24H52N2O11
- For research use only
Medchemexpress LLC CCND3 protein, human (biotinylated, MBP, His, Flag) | >85.0% | 20UG
Recombinant human CCND3 protein, biotinylated and fused to an N-terminal MBP with His and Flag tags, expressed in E. coli. The construct corresponds to CCND3 residues M1-L292 and is supplied in small research quantities (example: 20 μg). Characterization by reducing SDS-PAGE shows an apparent molecular weight of ~80 kDa and purity greater than 85%; consult the Certificate of Analysis for lot-specific data and storage instructions.
- Biotinylated for affinity capture and detection.
- N-terminal MBP fusion improves solubility.
- His and Flag tags enable purification and detection.
- Includes CCND3 residues M1-L292 for target-specific studies.
- Characterized by SDS-PAGE with >85% purity.
- Provided in small research-use quantities suitable for assay development.
Medchemexpress LLC Biotin-PEG8-acid | 2143964-62-7 | 99.8% | C29H53N3O12S | 50 MG
Biotin-PEG8-acid is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker: one for an E3 ubiquitin ligase and the other for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. It is for research use only.
- Appears as a white to off-white solid
- Molecular weight: 667.81
Medchemexpress LLC Cancer antigen 125 (MUC16), recombinant human, biotinylated | >95.0% | 50UG
Recombinant human CA125 (MUC16) is a biotinylated protein fragment (~685 amino acids) produced in HEK293 cells with C-terminal His and Avi tags. It is intended for binding studies, assay development, and detection workflows that use biotin-streptavidin capture.
- Biotinylated for streptavidin-based capture and detection.
- Expressed in HEK293 cells to provide mammalian glycosylation.
- C-terminal His and Avi tags for purification and site-specific biotinylation.
- Supplied at laboratory quantity suitable for assay development.
- High purity as determined by reducing SDS-PAGE (>95%).
- Molecular weight range 90-140 kDa reflecting glycosylated forms.
Medchemexpress LLC Interleukin 23 | >90.0% | 20UG
Recombinant human interleukin-23 (heterodimer of p19 and p40), biotinylated and produced in HEK293 cells. Supplied as a 0.2 μm filtered PBS solution, this protein is designed for research into IL-23 receptor binding, JAK/STAT signaling, and Th17-related immune responses. Handle and store according to supplier recommendations to maintain activity.
- Human IL-23 heterodimer (p19 + p40).
- Biotinylated for affinity-based detection and capture.
- Expressed in HEK293 mammalian cells for native glycosylation.
- Contains C-terminal His and Avi tags to facilitate purification and immobilization.
- Purity >90% as determined by reducing SDS-PAGE.
- Predicted molecular weight ~55.8 kDa.
- Supplied in PBS, 0.2 μm filtered; avoid repeated freeze-thaw cycles.
Medchemexpress LLC SPDP-C6-NHS ester | 158913-22-5 | 98.1% | 425.52 g/mol | C18H23N3O5S2 | 250MG
SPDP-C6-NHS ester is an NHS-activated, cleavable linker that contains a disulfide bond and is used for bioconjugation and PROTAC synthesis. The reagent couples to primary amines via its NHS ester and enables reversible linkage through disulfide reduction. It is supplied as a powder with specified storage and stability conditions and is intended for research use only.
- Cleavable disulfide linker for reversible conjugation
- NHS ester reactive toward primary amines
- Suitable for PROTAC synthesis and bioconjugation applications
- High purity (98.1% as listed)
- Available in multiple pack sizes, including 250 mg
- Powder storage recommendations: -20°C for long term, 4°C for shorter term