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Topiramate (CAS 97240-79-4) is an anticonvulsant compound widely investigated for its interactions with multiple neuronal ion channels and neurotransmitter receptors including AMPA kainate and NMDA glutamate receptors as well as GABA A receptors and voltage-gated Na channels In vitro studies demonstrate that at submicromolar concentrations (IC 0 5 M) topiramate selectively inhibits GluR5-containing kainate receptor-mediated excitatory synaptic currents in rat basolateral amygdala neurons and partially attenuates AMPA receptor-mediated responses Electrophysiological assays in cortical slices reveal that topiramate modulates persistent Na currents and shifts steady-state inactivation In animal models topiramate confers dose-dependent neuroprotection in ischemic stroke and elevates seizure thresholds supporting its utility for mechanistic studies of epilepsy and neuroprotection
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Topiramate (Standard) is a chemical compound suitable for laboratory research and the manufacture of substances. Identified by CAS number 97240-79-4, this product has a molecular formula of C12H21NO8S and appears as a solid. It is intended for research use only and should be handled by experienced personnel.
Used as a laboratory chemical
Suitable for the manufacture of substances
Stable under recommended storage conditions
Requires sealed storage at 4°C, away from light and moisture
Can be shipped at room temperature if less than 2 weeks
Harmful if swallowed
Causes skin irritation
Causes serious eye irritation
May cause respiratory irritation
Molecular weight of 339.36
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