Topiramate (McN 4853) is a solid, broad-spectrum antiepileptic agent and a GluR5 receptor antagonist. Its antiepileptic effects are attributed to multiple mechanisms, including enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, and inhibition of voltage-sensitive sodium and calcium channels. It is believed to block the spread of seizures.
- Enhances GABAergic activity.
- Inhibits kainate/AMPA receptors.
- Inhibits voltage-sensitive sodium and calcium channels.
- Increases potassium conductance.
- Inhibits carbonic anhydrase.