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SRI-37330 HCl(EX-A5854) an anti-diabetic drug is an orally bioavailable inhibitor of thioredoxin-interacting protein (TXNIP) with an IC50 of 0 64 M for TXNIP expression in INS-1 cells Its treatment inhibits glucagon secretion and function decreases hepatic glucose production and reverses hepatic steatosis
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