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Ertugliflozin is a potent, selective, and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2). It has an IC50 of 0.877 nM for h-SGLT2 and demonstrates over 2000-fold selectivity for SGLT2 inhibition relative to SGLT1 in vitro. This compound has potential for the treatment of type 2 diabetes mellitus.
Potent and selective SGLT2 inhibitor
Orally active
Demonstrated concentration-dependent glucosuria in vivo
Potential for type 2 diabetes mellitus treatment
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