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For researchers, scientists, and technical professionals: Your one-stop shop for the complete range of laboratory, production, and safety products and services.
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LAH5 is an amphipathic cell-penetrating peptide. LAH5 effectively delivers CRISPR-Cas9 components into the nuclei of target cells by forming nanocomplexes with both RNP and RNP/HDR cargo.
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Davercin (erythromycin cyclocarbonate) is a semi-synthetic erythromycin derivative used as an antimicrobial research compound; it inhibits bacterial protein synthesis and is active against Gram-positive and some Gram-negative microorganisms. The product is supplied as a powder and as a 10 mM solution in DMSO for laboratory and analytical use.
Derivative of erythromycin with antibacterial activity.
Inhibits protein synthesis by binding the 50S ribosomal subunit.
Available as powder and as a 10 mM solution in DMSO for convenience.
High reported purity suitable for analytical applications.
Stable when stored under recommended low-temperature conditions.
Intended for research use only; not for human or clinical use.
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Inhibits PKCδ (IC50 = 3 μM), CAM kinase III, and a wide range of protein kinases, including PRAK and MAPKAP-K2 (IC50s = 1.9 and 5 μM, respectively); stimulates autophagy by targeting a signaling cascade upstream of mTORC1
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Topiramate (CAS 97240-79-4) is an anticonvulsant compound widely investigated for its interactions with multiple neuronal ion channels and neurotransmitter receptors including AMPA kainate and NMDA glutamate receptors as well as GABA A receptors and voltage-gated Na channels In vitro studies demonstrate that at submicromolar concentrations (IC 0 5 M) topiramate selectively inhibits GluR5-containing kainate receptor-mediated excitatory synaptic currents in rat basolateral amygdala neurons and partially attenuates AMPA receptor-mediated responses Electrophysiological assays in cortical slices reveal that topiramate modulates persistent Na currents and shifts steady-state inactivation In animal models topiramate confers dose-dependent neuroprotection in ischemic stroke and elevates seizure thresholds supporting its utility for mechanistic studies of epilepsy and neuroprotection
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Ertugliflozin (MK-8835 PF-04971729) is a potent and selective sodium-dependent glucose cotransporter 2 inhibitor with IC50 values of 0 877 nM for h-SGLT2 and 1000-fold higher for h-SGLT1
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