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Dantrolene sodium hemiheptahydrate (CAS 24868-20-0) is an orally active noncompetitive inhibitor of glutathione reductase demonstrating inhibitory activity with a Ki of approximately 111 6 M and an IC50 of around 52 3 M In addition dantrolene inhibits ryanodine receptor calcium channels RyR1 and RyR3 thereby reducing intracellular calcium release This compound is utilized in studies investigating the dysregulation of calcium homeostasis such as those related to stroke ischemia-reperfusion injury and neurodegenerative disorders It is also explored in the contexts of muscle spasticity malignant hyperthermia analgesia anti-inflammatory responses and detoxification
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Medchemexpress, HY-12542A 100mg Dantrolene (sodium hemiheptahydrate) CAS:24868-20-0 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Dantrolene sodium hemiheptahydrate is the sodium salt hydrate form of dantrolene, a direct-acting skeletal muscle relaxant and ryanodine receptor (RyR) inhibitor used as a research reagent in studies of muscle spasm, malignant hyperthermia, and calcium-related pathophysiology. Supplied in multiple pack sizes for laboratory use.
High purity (99.8%).
Inhibits RyR-mediated Ca2+ release for calcium signaling studies.
Supplied as the hemiheptahydrate crystalline form.
Molecular weight 399.31 g·mol⁻¹.
Available in multiple pack sizes, including 500 mg.
Intended for laboratory research use only.
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Dantrolene sodium hemiheptahydrate is the sodium salt hydrate form of dantrolene used as a research reagent. It acts as a direct-acting skeletal muscle relaxant and inhibitor of calcium release from the sarcoplasmic reticulum, commonly used in studies of calcium homeostasis, malignant hyperthermia models, and muscle spasm pharmacology.
Purity 99.8% for reliable experimental consistency.
Molecular weight 399.31 g/mol and formula C14H16N4NaO8.5.
CAS number 24868-20-0 for substance traceability.
Solid, yellow to orange physical appearance.
Available in multiple pack sizes to suit laboratory needs.
Suitable for in vitro and in vivo research into calcium-related mechanisms.
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