AdipoGen Stevioside hydrate
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Chemical. CAS 57817-89-7 anhydrous. Formula C38H60O18 . xH2O. MW 804.9 anhydrous basis. Isolated from Stevia rebaudiana. Noncaloric natural sweetener, 300 times more potent than sucrose. Antidiabetic. Antihyperglycaemic and antihypoglycaemic. Potentiates insulin secretion. Enhances acetyl-CoA carboxylase ACC gene expression. Increases insulin sensitivity. Antihypertensive. Ca2 influx inhibitor. Anticancer compound. Chemopreventive. Anti-inflammatory. IKKbeta, NF-kappaB and MAPK signaling inhibitor. Induces TNF-alpha, IL-1beta and nitric oxide release. Immunomodulator. Increasees phagocytic activity, haemagglutination antibody titre, delayed type hypersensitivity. Increased proliferation in LPS and Con A stimulated B and T cells. Peripheral µ-opioid receptors activator. Important for regulation of glucose homeostasis. Anti-atherosclerotic. Review.