FAPy-adenine is an oxidized DNA base that shows increased levels in the Alzheimer's disease brain. It serves as a biochemical marker for tumors, aging, and neurodegenerative diseases. FAPy-adenine can form pairs with all four canonical nucleic acid bases, and its presence supports the concept of increased oxidative stress in the brain during Alzheimer's disease due to nuclear DNA damage by oxygen-derived radicals.
- Oxidized DNA base
- Increased levels in Alzheimer's disease brain
- Biochemical marker for tumors, aging, and neurodegenerative diseases
- Forms pairs with all four canonical nucleic acid bases
- Supports understanding of oxidative stress in Alzheimer's disease