Lactams
Sigma Aldrich Fine Chemicals Biosciences 7-Aminodesacetoxycephalosporanic acid | 22252-43-3 | MFCD09750368 | 1G
7-Aminodesacetoxycephalosporanic acid | Mol Wt: 214.24 | 22252-43-3 | MFCD09750368 | 1G
Medchemexpress LLC Thalidomide-pyrrolidine hydrochloride | 2616553-35-4 | 98.0% | 335.74 g·mol⁻¹ | C15H14ClN3O4 | 100 MG
Thalidomide-pyrrolidine hydrochloride is an E3 ligase ligand (compound 18) used as a building block in the synthesis of PROTACs. Provided as the hydrochloride salt at research-grade purity, it is supplied in milligram-scale packages and includes storage recommendations for long-term stability.
- E3 ligase ligand suitable for PROTAC assembly.
- Hydrochloride salt form for improved handling.
- High purity: 98.0%.
- Molecular weight: 335.74 g·mol⁻¹.
- CAS number: 2616553-35-4.
- Available in multiple package sizes including 100 mg.
- Storage recommendations: in solvent -80°C for 2 years, -20°C for 1 year.
Medchemexpress LLC Thalidomide-5-O-C2-NH2 hydrochloride | 2694727-89-2 | 98.0% | 353.76 g/mol | C15H16ClN3O5 | 10 MG
Thalidomide-5-O-C2-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as the hydrochloride salt. It is used as an E3 ligase ligand-linker conjugate in targeted protein degradation research and PROTAC synthesis, enabling the attachment of linkers or functional groups to the thalidomide scaffold for chemical biology applications.
- High reported purity, 98.0%.
- Supplied as the hydrochloride salt for improved handling.
- Functions as a cereblon (CRBN) ligand for E3 ligase recruitment.
- Suitable for PROTAC synthesis and ligand-linker conjugation.
- Characterized by CAS 2694727-89-2 and molecular weight 353.76 g/mol.
- Available in small research pack sizes such as 10 MG.
Medchemexpress LLC Thalidomide-5-O-C4-NH2 hydrochloride | 2694727-93-8 | 100.0% | 381.81 g/mol | C17H20ClN3O5 | 10 MG
Thalidomide-5-O-C4-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand intended for chemical biology research and PROTAC design. Supplied as a white to off-white solid in small milligram quantities, the compound functions as an E3 ligase recruiting moiety that can be connected to target ligands via linkers for targeted protein degradation studies.
- High purity suitable for research applications (reported ~99.98%).
- Acts as a cereblon-binding ligand for E3 ligase recruitment.
- Designed for PROTAC synthesis and linker conjugation.
- Available in small milligram pack sizes for screening and synthesis.
- Solid form, white to off-white, stable under recommended storage.
- Includes CAS number 2694727-93-8 for unambiguous identification.
Medchemexpress LLC Thalidomide-5-COOH | 1216805-11-6 | 99.9% | 302.24 | 500 MG
Thalidomide-5-COOH is a Thalidomide-based cereblon ligand utilized for the recruitment of CRBN protein. It can be linked to a protein ligand via a linker to form PROTACs.
- Utilized for the recruitment of CRBN protein
- Can be linked to a protein ligand via a linker
- Forms PROTACs
- PROTACs use the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Thalidomide-O-C6-NHBoc | 2509093-23-4 | 95.99% | C24H31N3O7 | 250 MG
Thalidomide-O-C6-NHBoc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. It is for research use only.
- E3 ligase ligand-linker conjugate
- Incorporates thalidomide based cereblon ligand
- Used in PROTAC technology
- For research use only
- Inhibitor
Medchemexpress LLC Thalidomide-O-PEG4-amine (hydrochloride) | 2820929-03-9 | C23H32ClN3O9 | 50 MG
Thalidomide-O-PEG4-amine hydrochloride is a synthesized E3 ligase ligand-linker conjugate. It incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. This conjugate exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Incorporates thalidomide based cereblon ligand
- Uses a linker in PROTAC technology
- Targets E3 ligase ligand-linker conjugates, apoptosis, and autophagy
Medchemexpress LLC Thalidomide-NH-PEG3-COOH | 2375283-62-6 | 98.9% | 477.46 | 100 MG
Thalidomide-NH-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate. It incorporates a thalidomide-based cereblon ligand and a linker utilized in PROTAC technology. This product is intended for research purposes only.
- Incorporates a thalidomide-based cereblon ligand
- Designed for use in PROTAC technology
- Targets cereblon
- Appears as a white to yellow solid
- Useful in cancer research applications
- Functions as an E3 ligase ligand-linker conjugate
- Involved in autophagy and apoptosis studies
- Acts as an inhibitor
Medchemexpress LLC Thalidomide-5-O-C10-NH2 hydrochloride | 99.4% | 465.97 g/mol | C23H32ClN3O5 | 10 MG
Thalidomide-5-O-C10-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as the hydrochloride salt for chemical biology research. It is used to recruit the CRBN E3 ubiquitin ligase in PROTAC and conjugate applications to enable targeted protein ubiquitination and degradation. Molecular formula C23H32ClN3O5; molecular weight 465.97 g/mol.
- Used as a cereblon-binding ligand for PROTAC and conjugate design.
- Supplied as the hydrochloride salt for improved handling and stability.
- High purity suitable for research applications.
- Available in small research pack sizes for synthesis and screening.
- Provides a chemical handle designed for linker attachment to target ligands.
Medchemexpress LLC Thalidomide-NH-PEG3-COOH | 2375283-62-6 | 98.9% | 477.46 | 25 MG
Thalidomide-NH-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate. It incorporates the Thalidomide-based cereblon ligand and a linker utilized in PROTAC technology. PROTACs (Proteolysis Targeting Chimeras) are designed with two different ligands connected by a linker, enabling the selective degradation of target proteins.
- Incorporates Thalidomide-based cereblon ligand
- Utilizes a linker for PROTAC technology
- Designed for selective degradation of target proteins
- For research use only
Medchemexpress LLC Thalidomide-4-O-C5-NH2 hydrochloride | 2419145-66-5 | 96.9% | 395.84 | 25 MG
Thalidomide-4-O-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate. It incorporates a thalidomide-based cereblon ligand and a linker used in PROTAC technology. PROTACs (Proteolysis Targeting Chimeras) consist of two different ligands connected by a linker: one for an E3 ubiquitin ligase and the other for the target protein. They are utilized to exploit the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide-based cereblon ligand
- Utilizes PROTAC technology for selective degradation of target proteins
- Exploits the intracellular ubiquitin-proteasome system
Medchemexpress LLC Thalidomide-Piperazine-PEG2-NH2 (diTFA) | 99.7% | 701.57 | 25 MG
Thalidomide-Piperazine-PEG2-NH2 diTFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide-based cereblon ligand and a linker used in PROTAC technology. It is for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide-based cereblon ligand
- Includes a linker used in PROTAC technology
- Targets Cereblon
- Utilizes the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins