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Lactams

Organic heterocyclic compounds that contain a cyclic amide; amide groups consist of a carbonyl carbon atom linked by a single bond to a nitrogen atom and either a hydrogen or a carbon atom. These compounds are the nitrogen analogs of lactones.

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Medchemexpress LLC 3-(2-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)ethoxy)propanoic acid | 2731007-11-5 | 99.2% | C22H26N4O7 | 10MG
SDP

Thalidomide-Piperazine-PEG1-COOH is an E3 ligase ligand-linker conjugate combining a thalidomide-derived cereblon ligand with a short PEG1-piperazine linker terminated by a carboxylic acid. It is provided as a solid research reagent intended for use as a CRBN-binding module in PROTAC design and conjugation studies.

  • Enables CRBN engagement via a thalidomide-derived ligand.
  • Features a PEG1-piperazine linker with a terminal carboxylic acid for conjugation.
  • High reported purity enables reliable analytical and synthetic work.
  • Solid, white-to-yellow appearance for easy handling and storage.
  • Recommended storage at -20°C under inert gas to preserve integrity.
  • Available in small milligram quantities suitable for early-stage research.

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2

Medchemexpress LLC 11-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}undecanoic acid | 2379870-45-6 | MFCD03424822 | 99.1% | C24H30N2O7 | 10MG
SDP

Thalidomide-4-O-C10-COOH is a thalidomide-derived cereblon (CRBN) E3 ligase ligand-linker conjugate provided for research use as a synthetic intermediate in the preparation of proteolysis-targeting chimeras (PROTACs). The molecule features a ten-carbon linker terminating in a carboxylic acid, and is supplied as a solid with formula C24H30N2O7 and molecular weight 458.50 g·mol⁻¹.

  • Thalidomide-based cereblon (CRBN) ligand-linker conjugate.
  • Suitable for PROTAC synthesis and E3 ligase recruitment studies.
  • Contains a C10 linker with a terminal carboxylic acid for conjugation.
  • High reported purity (99.1%).
  • Supplied as a solid; molecular formula C24H30N2O7, molecular weight 458.50 g·mol⁻¹.
  • For research use only; not for human therapeutic use.

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