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Organic heterocyclic compounds that consist of a cyclic carboximidic acid characterized by a carbon-nitrogen double bond within the ring; they are tautomeric with the lactams.
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AP-C5 is a selective small-molecule inhibitor of cGMP-dependent protein kinase II (cGKII) used in cellular and biochemical research, including studies of diarrheal disease. It also contains an alkyne functional group that enables copper-catalyzed azide-alkyne cycloaddition (click chemistry) for probe conjugation.
Selective cGKII inhibition suitable for biochemical and cellular assays.
Click-chemistry compatible alkyne for facile probe conjugation.
High purity (>98%) for consistent experimental performance.
Solid, light yellow to light brown physical form for straightforward handling.
Stable when stored under recommended conditions for long-term use.
Good solubility in DMSO for preparation of screening solutions.
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Glutarimide-Isoindolinone-NH-PEG4-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates a cereblon ligand and a linker used in PROTAC technology. Proteolysis Targeting Chimeras (PROTACs) consist of two different ligands connected by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets the protein of interest. PROTACs function by leveraging the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Synthesized E3 ligase ligand-linker conjugate
Incorporates a cereblon ligand
Used in PROTAC technology
Leverages the intracellular ubiquitin-proteasome system
Selectively degrades target proteins
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