Lactims

Medchemexpress LLC 2-Pyrimidinamine, 4-[4-(1H-imidazol-1-yl)phenyl]-N-2-propyn-1-yl- | 2234272-10-5 | 98.1% | 50 MG

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AP-C5 is a selective inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC50 of 7.2. It is used for the research of diarrheal disease. This compound is also a click chemistry reagent containing an Alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules that contain Azide groups.

• Potent inhibition of cGMP-dependent cGKII-mediated protein phosphorylation
• Effective inhibition of cGMP-dependent, CFTR-mediated anion secretion in intestinal tissue
• Potentiates cAMP signaling through PDE inhibition
• Partially blocks heat-stable toxin (STa)-mediated short-circuit current (Isc) response in mouse ileum
• Click chemistry reagent with an alkyne group
• Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)

Medchemexpress LLC 6-(3,4-dibromo-2,5-dioxopyrrol-1-yl)hexanoic acid | 1443214-97-8 | MFCD09813286 | 99.4% | 369.01 g/mol | C10H11Br2NO4 | 50 MG

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Dibromomaleimide-C5-COOH is a bifunctional dibromomaleimide linker used in antibody-drug conjugate synthesis to connect payloads such as MMAF. It is supplied as a white to off-white solid with high purity and is soluble in DMSO.

• Bifunctional dibromomaleimide linker for ADC synthesis.
• High purity (99.4%) suitable for research applications.
• Molecular weight 369.01 g/mol and formula C10H11Br2NO4.
• Soluble in DMSO at ≥100 mg/mL.
• Available in small-scale quantities (5-200 mg) for conjugation workflows.
• Store at 4°C under nitrogen; in solvent store at -80°C (6 months) or -20°C (1 month).

TARGETMOL CHEMICALS INC COMPLEMENT C5-IN-1 5MG

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Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Complement C5-IN-1 is a small-molecule inhibitor of complement component 5 protein (C5). purity: 99%

Medchemexpress LLC Complement C5-IN-1 | 2365402-67-9 | 99.1% | 1 ML

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Complement C5-IN-1 is a selective allosteric inhibitor of complement component protein C5. It prevents C5 from being cleaved by C5 convertase, which inhibits the cleavage of C5 into C5a and C5b, thus blocking the formation of the membrane attack complex (MAC).

• Selective allosteric inhibitor of complement component protein C5
• Prevents C5 from being cleaved by C5 convertase
• Inhibits the cleavage of C5 into C5a and C5b
• Blocks the formation of the membrane attack complex (MAC)
• Exhibits an IC50 of 0.77 μM in 50% human whole blood
• Exhibits an IC50 of 5 nM in 2% human serum to block MAC deposition induced by zymosan
• Useful for studying diseases associated with complement overactivation, such as paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS)