Oxazinanes
Cayman Chemical LtreoPDMP hydrochloride
An enhancer of ganglioside biosynthesis; increases the activity of ganglioside GM3, -GD3, and -GQ1b synthases in primary rat cortical neurons; increases the levels of glucosylceramide, lactosylceramide, and ganglioside GM3 in B16 melanoma cells; increases neurite outgrowth in primary rat neocortical explants at 15 µM; increases functional synapse formation in primary rat cortical neurons at 20 µM; improves retention of a long-term memory learned prior to forebrain ischemia in rats when administered after ischemia at 40 mg/kg per day
Selleck Chemical LLC Crizotinib hydrochloride S5190-5mg
Crizotinib (PF-02341066) hydrochloride (Xalkori) inhibits tyrosine phosphorylation of c-Met and nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) with IC50 of of 11 nM and 24 nM in cell-based assays respectively Crizotinib hydrochloride is also a potent ROS1 inhibitor with Ki less than 0 025 nM Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines
TARGETMOL CHEMICALS INC Syk Inhibitor II hydrochloride
Also available in 1 mL, 1 mg, 5 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. The impact of spleen tyrosine kinase (Syk) signaling might be prominent in lupus because (i) Syk is a shared downstream signaling molecule among circulating immune complex, LPS, and (1→3)-beta-D-glucan (BG), and (ii) all of these factors are detectable in the serum of Fc gamma receptor IIb-deficient (FcgRIIb-/-) mice with sepsis. Syk inhibition downregulated several inflammatory pathways in FcgRIIb-/- macrophages activated with BG + LPS suggesting the potential anti-inflammatory impact of Syk inhibitors in lupus. Indeed, administration of a Syk inhibitor prior to cecal ligation and puncture (CLP) sepsis in FcgRIIb-/- mice reduced baseline lupus-induced proinflammatory cytokines and attenuated sepsis severity as evaluated by mortality, organ injury, serum LPS, and post-sepsis serum cytokines. Purity 98.17%
Apexbio Technology LLC Rilmenidine (hemifumarate) 207572-68-7 5mg
Rilmenidine (hemifumarate CAS 207572-68-7) is an antihypertensive small molecule that primarily acts as an agonist at imidazoline I1 receptors within the rostral ventrolateral medulla thereby inhibiting the tonic activity of sympathoexcitatory neurons and reducing arterial pressure In vitro assays show that rilmenidine displays approximately 30-fold selectivity for imidazoline versus 2-adrenergic binding sites and a Ki of 7 1 nM for I1 receptors with significantly lower affinity for I2 sites (Ki 5 2 M) In vivo studies indicate efficacy in lowering blood pressure and ameliorating features of metabolic syndrome in rodent models as well as inducing autophagy and attenuating neurodegenerative pathology in a mouse model of Huntington s disease supporting its utility in cardiovascular and neurodegenerative research
Apexbio Technology LLC Alosetron Hydrochloride 122852-69-1 10mM (in 1mL DMSO)
Alosetron Hydrochloride (CAS 122852-69-1) is a potent antagonist of the serotonin 5-HT3 receptor a ligand-gated ion channel implicated in the modulation of gastrointestinal function By selectively inhibiting 5-HT3 receptor-mediated signaling on enteric neurons Alosetron modulates visceral sensation and gastrointestinal motility This mechanism underlies its application in the study of serotonergic pathways involved in irritable bowel syndrome and related gastrointestinal disorders Alosetron serves as a valuable tool in biomedical research investigating the neurogastroenterology of serotonergic signaling and its role in gut-brain axis modulation
TARGETMOL CHEMICALS INC Ezurpimtrostat hydrochloride
Also available in 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Ezurpimtrostat hydrochloride (GNS561 hydrochloride) is an orally available palmitoyl protein thioesterase-1 inhibitor with antifibrotic, antiviral, and anticancer effects that blocks cancer cell proliferation by interacting with palmitoyl protein thioesterase to inhibit late autophagy and dose-dependently increase lysosomal accumulation. Purity 99.84%
TARGETMOL CHEMICALS INC Milnacipran hydrochloride
Also available in 10 mg, 25 mg, 50 mg, 200 mg, 500 mg and bulk. Please contact Fisher for quotes. Milnacipran hydrochloride (Savella) is a serotonin and norepinephrine reuptake inhibitor used to treat major depressive disorders. Milnacipran hydrochloride is an enantiomer of milnacipran, which is used to treat fibromyalgia. Milnacipran hydrochloride and milnacipran have been associated with a low rate of transient elevations in serum aminotransferase levels during treatment and with rare instances of clinically apparent acute liver injury with jaundice. Purity 100%
Apexbio Technology LLC SKF 525A (hydrochloride) 62-68-0 1g
SKF 525A (hydrochloride CAS 62-68-0) is a small-molecule inhibitor of cytochrome P450 (CYP) enzymes It modulates CYP-mediated metabolic pathways by inhibiting several isoforms including CYP2B6 CYP2C9 CYP2C19 CYP2D6 and CYP3A with limited impact on CYP1A2 CYP2A6 and CYP2E1 When assessed in human liver microsomes SKF 525A demonstrates CYP-dependent N-deethylation and exhibits inhibitory potency in the micromolar range In animal models it non-specifically disrupts sympathetic ganglia and adrenal medulla signaling possibly by stabilizing postsynaptic membranes SKF 525A is commonly used to study drug metabolism and CYP-mediated biotransformation in preclinical settings
Selleck Chemical LLC Sarpogrelate hydrochloride S3706-10mg
Sarpogrelate (MCI-9042) is a selective 5-HT2A antagonist with pKi values of 8 52 7 43 and 6 57 for 5-HT2A 5-HT2C and 5-HT2B receptors respectively