Oxazinanes
Medchemexpress LLC 1(2H)-Naphthalenone, 6-bromo-3,4-dihydro- | 66361-67-9 | 225.09 | 10 G
6-Bromo-3,4-dihydro-1(2H)-naphthalenone is a biochemical reagent intended for life science related research. It serves as a biological material or organic compound and is for research use only.
- Used as a biochemical reagent
- Suitable for life science research
- Appearance: Solid
- For research use only
Medchemexpress LLC Pramipexole dihydrochloride hydrate | 191217-81-9 | 98.0% | 50 MG
Pramipexole dihydrochloride hydrate is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist. It is intended for research in conditions such as Parkinson's disease (PD) and restless legs syndrome (RLS).
- Selective and blood-brain barrier penetrant dopamine D2-type receptor agonist
- Ki values for D2-type receptor, D2, D3, and D4 receptors are 2.2 nM, 3.9 nM, 0.5 nM, and 1.3 nM respectively
- Suitable for Parkinson's disease and restless legs syndrome research
- Produces dose-dependent increases in dendritic arborization and soma size
- Attenuates levodopa-induced toxicity in mesencephalic cultures
- Reduces infarction volume and improves neurological recovery in animal models
Medchemexpress LLC (6S)-CP-470711 | 300552-09-4 | 98.8% | 358.44 | 25 MG
(6S)-CP-470711 (Compound 8) is an inhibitor of sorbitol dehydrogenase (SDH), with IC50 values of 19 nM for human SDH and 27 nM for rat SDH. It has been shown to improve Streptozotocin-induced diabetes in rat models.
- Inhibits human and rat sorbitol dehydrogenase (SDH) with IC50 values of 19 nM and 27 nM, respectively.
- Ameliorates streptozotocin-induced diabetes in rat models.
- Solid appearance, white to off-white color.
- For research use only.
Medchemexpress LLC Elacestrant dihydrochloride | 1349723-93-8 | 99.5% | 531.56 | 25 MG
Elacestrant dihydrochloride is an orally available and selective estrogen receptor degrader (SERD) with IC50s of 48 nM for ERα and 870 nM for ERβ. It can also inhibit the growth of ER+ breast cancer cell lines in vitro and in vivo. This compound is designed for high-speed applications in research settings.
- Inhibits ERα expression with an EC50 of 0.6 nM in MCF-7 cells.
- Decreases expression of progesterone receptor in MCF7 and T47D cell lines.
- Antagonizes E2-mediated uterine stimulation in a dose-dependent manner in vivo.
- Induces complete tumor growth inhibition in mice.
- Maintains tumor growth inhibition for 4 weeks after withdrawal.
Medchemexpress LLC 9-Dihydro-13-acetylbaccatin III (9-DHAB III) | 142203-65-4 | 99.6% | C33H42O12 | 1 ML
9-Dihydro-13-acetylbaccatin III (9-DHAB III) is an intermediate used in the preparation of paclitaxel analogs. This compound exhibits antiproliferative activity against mouse P388 cells, as determined by MTT assay.
- Intermediate for paclitaxel analog preparation
- Purity of 99.6%
- White to off-white solid appearance
- Classified as terpenoids and diterpenoids
- Derived from Taxus chinensis plants
- Demonstrates antiproliferative activity against P388 cells
- Powder stable for up to 3 years at -20°C or 2 years at 4°C
- Solution stable for up to 2 years at -80°C or 1 year at -20°C
- Soluble in DMSO at 20 mg/mL
eMolecules 124072-89-5 | Hexahydropyridazine dihydrochloride | Combi-Blocks, Inc. | MFCD09037903 | 159.050 | C4H12Cl2N2 | 97.000 | Cl.Cl.C1CCNNC1 | 5g | 589787948
Hexahydropyridazine dihydrochloride | Combi-Blocks, Inc. | 124072-89-5 | MFCD09037903 | 159.050 | C4H12Cl2N2 | 97.000 | Cl.Cl.C1CCNNC1 | 5g | 589787948
eMolecules 109-11-5 | Morpholin-3-one | Combi-Blocks | MFCD00631009 | 101.105 | C4H7NO2 | 97.000 | O=C1COCCN1 | 25g | 205392710
Morpholin-3-one | Combi-Blocks | 109-11-5 | MFCD00631009 | 101.105 | C4H7NO2 | 97.000 | O=C1COCCN1 | 25g | 205392710
Medchemexpress LLC eIF4A3-IN-8 | 18474-59-4 | 99.9% | 175.18 | 250 MG
eIF4A3-IN-8 is a selective ATP-competitive eukaryotic initiation factor 4A3 (eIF4A3) inhibitor. It can serve as a valuable chemical probe to elucidate the detailed function of eIF4A3 and EJC (exon junction complex).
- Selective ATP-competitive eIF4A3 inhibitor
- Can be used as a chemical probe to study eIF4A3 and EJC
Medchemexpress LLC 9-Dihydro-13-acetylbaccatin III | 142203-65-4 | 99.6% | C33H42O12 | 50 MG
9-Dihydro-13-acetylbaccatin III (9-DHAB III) is an intermediate used for the preparation of paclitaxel analogs and is intended for research use only. It exhibits antiproliferative activity against mouse P388 cells with an IC50 of 20 μg/mL.
- Intermediate for the preparation of paclitaxel analogs
- Intended for research use only
- Exhibits antiproliferative activity against mouse P388 cells
- Molecular weight of 630.68
- Chemical formula is C33H42O12
- CAS number is 142203-65-4
- Appears as a white to off-white solid
- Derived from Taxus chinensis (Pilger) Rehd.
Medchemexpress LLC 3-amino-2-oxazolidinone (AOZ) | 80-65-9 | 98.0% | 102.09 | 25 MG
3-Amino-2-oxazolidinone (AOZ) is a metabolite of Furazolidone. It is used as an indicator for furazolidone residues in vivo and is orally active. Research indicates it inhibits monoamine oxidase (MAO) through its metabolite in rat brain and liver, increasing monoamine neurotransmitter levels like norepinephrine and dopamine, and lowering blood pressure in renal hypertensive rats. It has been observed to reduce blood pressure in renal hypertensive rat models by 60% at a dosage of 30 mg/kg administered orally once daily for 10 days. This product is for research use only and not sold to patients.
- Metabolite of furazolidone
- Used as an indicator for furazolidone residues in vivo
- Orally active
- Inhibits monoamine oxidase (MAO)
- Increases monoamine neurotransmitter levels
- Lowers blood pressure in renal hypertensive rats
- For research use only
Medchemexpress LLC 7,8-Dihydro-L-biopterin | 6779-87-9 | 99.8% | 239.23 | 50 MG
7,8-Dihydro-L-biopterin | 6779-87-9 | 99.8% | 239.23 | 50 MG