Oxazinanes
TARGETMOL CHEMICALS INC CHPG HYDROCHLORIDE 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. CHPG hydrochloride is a selective agonist of mGluR5.
Medchemexpress LLC Inolitazone dihydrochloride | 223132-38-5 | 98.5% | 575.51 | 100 MG
Inolitazone dihydrochloride is a novel high-affinity PPARγ agonist, demonstrating potent anti-proliferative activities both in vitro and in vivo, with an IC50 of 0.8 nM for growth inhibition. Its biological activity is dependent on PPARγ.
- Upregulates the cell cycle kinase inhibitor p21WAF1/CIP1
- Activates PPARγ:RXRα-dependent transcription at 10 nM
- Specifically activates PPARγ, unlike PPARα or PPARδ
- Exhibits a low EC50 of 1 nM for activating PPARγ in DRO cells
- Potently inhibits growth with an IC50 of 0.8 nM
- Shows additive antiproliferative activity when combined with paclitaxel
- Inhibits tumor growth in a dose-responsive manner in vivo, including established DRO and ARO tumors
TARGETMOL CHEMICALS INC LY-294002 HYDROCHLORIDE 25MG
Also available in 1 mg 2 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. LY-294002 hydrochloride (NSC 697286) is a synthetic molecule inhibitor of PI3K(alpha)/(delta)/(beta) (IC50 0.5/0.57/0.97 uM in cell-free assays); more stable than Wortmannin in solution and also is a blocker of autophagosome formation. purity: 99%
![Medchemexpress LLC Phenol, 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-, hydrochloride (1:2) | 69-44-3 | 99.97% | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000411980-logo.png-250.jpg){kind=logo}
Medchemexpress LLC Phenol, 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-, hydrochloride (1:2) | 69-44-3 | 99.97% | 1 ML
Amodiaquine dihydrochloride is a 4-aminoquinoline antimalarial agent that is orally active. It functions as a potent inhibitor of histamine N-methyltransferase with a Ki of 18.6 nM, and also acts as a Nurr1 agonist, binding specifically to its ligand-binding domain with an EC50 of approximately 20 μM. This compound also demonstrates anti-inflammatory effects and is for research use only.
- Purity: 99.97%
- Molecular weight: 428.78
- Formula: C20H24Cl3N3O
- CAS number: 69-44-3
- Appearance: Solid
- Color: Light yellow to yellow
- Solubility: Greater than or equal to 125 mg/mL in DMSO (requires sonication), greater than or equal to 50 mg/mL in water (requires sonication)
Medchemexpress LLC Flunarizine dihydrochloride | 30484-77-6 | 99.9% | 10 G
Flunarizine dihydrochloride is a potent dual Na+/Ca2+ channel (T-type) blocker and a D2 dopamine receptor antagonist. It demonstrates anticonvulsive and antimigraine activity, as well as peripheral vasodilator effects.
- Potent dual Na+/Ca2+ channel (T-type) blocker
- D2 dopamine receptor antagonist
- Shows anticonvulsive and antimigraine activity
- Provides peripheral vasodilator effects
- For research use only
TARGETMOL CHEMICALS INC TIPIRACIL HYDROCHLORIDE 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 200 mg 500 mg and bulk. Please contact Fisher for quotes. Tipiracil hydrochloride (MA-1 hydrochloride) is a thymidine phosphorylase inhibitor (TPI). Tipiracil hydrochloride is one of the active components in TAS-102 which is an anticancer drug candidate currently in clinical trials. purity: 99%
Medchemexpress LLC VU591 hydrochloride | 1315380-70-1 | 98.9% | 404.76 | 1 ML
VU591 hydrochloride is a potent, selective renal outer medullary potassium channel (ROMK or Kir1.1) inhibitor, with an IC50 of 0.24 μM. It can be used for neurological research with HY-108585A (the equivalent of VU591 hydrochloride).
- Potent, selective renal outer medullary potassium channel (ROMK or Kir1.1) inhibitor
- IC50 of 0.24 μM
- Suitable for neurological research
- Binds serum protein
- High metabolic stability
- Shows antidepressive effect in male ICR mice
Medchemexpress LLC Pyrithioxin dihydrochloride | 10049-83-9 | 98.0% | 500 MG
Pyrithioxin (Pyritinol) dihydrochloride is the dihydrochloride salt of Pyrithioxin. Pyrithioxin (Pyritinol) is an orally active neurodynamic compound. Pyrithioxin can promote the metabolism of glucose and amino acids, increase carotid blood flow and improve cerebral blood flow. Pyrithioxin exhibits anti-inflammation, anti-tumor and neuroprotective effect. Pyrithioxin can be used for the researches of cancer, inflammation, immunology, metabolic and neurological disease such as cerebral infarct, epilepsy, fibrosarcomas and rheumatoid polyarthritis.
- Promotes metabolism of glucose and amino acids
- Increases carotid blood flow and improves cerebral blood flow
- Exhibits anti-inflammation effects
- Exhibits anti-tumor effects
- Provides neuroprotective effects
Medchemexpress LLC Quizartinib dihydrochloride | 1132827-21-4 | 99.8% | C29H34Cl2N6O4S | 100 MG
Quizartinib dihydrochloride (AC220 dihydrochloride) is the dihydrochloride salt form of Quizartinib. This compound is an orally active, highly selective, and potent second-generation type II FLT3 tyrosine kinase inhibitor, characterized by a Kd of 1.6 nM. It is intended for research use only.
- Highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor
- Effectively inhibits wild-type FLT3 and FLT3-ITD autophosphorylation
- Can be utilized in PROTAC technology to create FLT3 degraders
- Capable of inducing apoptosis
- Provides high purity for reliable research results
- Presents as a white to off-white solid
Selleck Chemical LLC Arecaidine hydrochloride
Arecaidine hydrochloride a constituent of the nut of Areca catechu inhibits the uptake of GABA and beta-alanine but not that of glycine
Medchemexpress LLC Tebanicline dihydrochloride | 209326-19-2 | 99.5% | C9H13Cl3N2O | 1 ML
Tebanicline dihydrochloride is a potent, orally effective analgesic that modulates neuronal nicotinic acetylcholine receptors (nAChRs). It exhibits high selectivity for neuronal nAChRs, acting as an agonist, and effectively inhibits cytisine binding to α4β2 neuronal nAChRs. This product is investigated for its potential in treating various types of pain and for its anxiolytic-like properties.
- Potent and orally effective analgesic.
- Highly selective for neuronal nAChRs.
- Shows efficacy in models of acute, persistent, chemical, and neuropathic pain.
- Investigated for anxiolytic-like activity.
TARGETMOL CHEMICALS INC CX-6258 HYDROCHLORIDE 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. CX-6258 hydrochloride (Pim-Kinase Inhibitor X) is an effective orally efficacious Pim1/2/3 kinase inhibitor (IC50 5/25/16 nM). purity: 98%
Cayman Chemical LthreoPDMP hydrochloride
An enhancer of ganglioside biosynthesis; increases the activity of ganglioside GM3, -GD3, and -GQ1b synthases in primary rat cortical neurons; increases the levels of glucosylceramide, lactosylceramide, and ganglioside GM3 in B16 melanoma cells; increases neurite outgrowth in primary rat neocortical explants at 15 µM; increases functional synapse formation in primary rat cortical neurons at 20 µM; improves retention of a long-term memory learned prior to forebrain ischemia in rats when administered after ischemia at 40 mg/kg per day
TARGETMOL CHEMICALS INC GSA-10 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. GSA-10 is a potent Smoothened (Smo) receptor agonist with an EC50 of 1.2 uM. It acts on Smo to promote the differentiation of pluripotent mesenchymal stem cells into osteoblasts. It also mediates Hedgehog (Hh) signaling which may have research implications for regenerative medicine in cancer diseases. purity: 98%
TARGETMOL CHEMICALS INC ACORAMIDIS HYDROCHLORIDE 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Acoramidis hydrochloride (Alxn2060 hydrochloride) is an orally active and selective kinetic stabilizer of WT and V122I- TTR (transthyretin) . Acoramidis hydrochloride is used in the study for transthyretin amyloidosis. purity: 99%