Oxazinanes
Selleck Chemical LLC Dapiprazole Hydrochloride S5281-25mg
Dapiprazole Hydrochloride (Glamidolo Hydrochloride Reversil Hydrochloride) is the hydrochloride salt form of dapiprazole an alpha-adrenergic blocker used to reverse mydriasis after eye examination
Selleck Chemical LLC Atipamezole hydrochloride S4649-50mg
Atipamezole (Antisedan MPV1248) is a synthetic 2 adrenergic receptor antagonist It has also been researched in humans as a potential anti-Parkinsonian drug Atipamezole hydrochloride is hydrochloride form of atipamezole
Medchemexpress LLC PJ34 (hydrochloride) | 344458-15-7 | 99.8% | 331.80 | 1 ML
PJ34 hydrochloride is an inhibitor of PARP1/2, with IC50 values of 110 nM for PARP1 and 86 nM for PARP2. It effectively inhibits PARP enzyme activity. In vitro, it attenuates cell death in PC12 cells, and in vivo studies show it significantly reduces cortical damage and decreases inflammatory mRNA levels in ischemic animals.
- Inhibits PARP1 and PARP2 activity.
- Attenuates cell death in PC12 cells.
- Reduces cortical damage in vivo.
- Decreases TNF-α mRNA levels.
- Reduces E-selectin and ICAM-1 mRNA levels.
Medchemexpress LLC Di(N-succinimidyl)adipate | 59156-70-6 | 95.0% | C14H16N2O8 | 250 MG
Di(N-succinimidyl)adipate is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Alkyl chain-based PROTAC linker
- Suitable for synthesizing PROTACs
- Utilizes the ubiquitin-proteasome system for protein degradation
Medchemexpress LLC Quizartinib dihydrochloride | 1132827-21-4 | 99.8% | C29H34Cl2N6O4S | 100 MG
Quizartinib dihydrochloride (AC220 dihydrochloride) is the dihydrochloride salt form of Quizartinib. This compound is an orally active, highly selective, and potent second-generation type II FLT3 tyrosine kinase inhibitor, characterized by a Kd of 1.6 nM. It is intended for research use only.
- Highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor
- Effectively inhibits wild-type FLT3 and FLT3-ITD autophosphorylation
- Can be utilized in PROTAC technology to create FLT3 degraders
- Capable of inducing apoptosis
- Provides high purity for reliable research results
- Presents as a white to off-white solid
Biomatik Corporation BCIP, Toluidine Salt (BCIP-T). Grade Ultra Pure. Storage -20C. CAS 6578-06-9
BCIP, Toluidine Salt (BCIP-T). Grade Ultra Pure. Storage -20C. CAS 6578-06-9
Selleck Chemical LLC Pitolisant hydrochloride
Pitolisant (Tiprolisant BF-2649) acts as a high-affinity competitive antagonist (Ki 0 16 nM) and as an inverse agonist (EC50 1 5 nM) at the human histamine H3 receptor subtype
Selleck Chemical LLC SB 271046 hydrochloride S2856-10mg
SB 271046 hydrochloride is a potent selective and orally active 5-HT6 receptor antagonist with pKi of 8 9 exhibits 200-fold greater selectivity over other 5-HT receptor subtypes
eMolecules Acrotein ChemBio Inc. 4-(Methylamino)butanoic acid ethyl ester HCl 1g 705837559 A-3372 81893-75-6 MFCD17215565 181.660 C7H16ClNO2
Acrotein ChemBio Inc. 4-(Methylamino)butanoic acid ethyl ester HCl 1g 705837559 A-3372 81893-75-6 MFCD17215565 181.660 C7H16ClNO2
Cayman Chemical RIluzolehydrochlorIde 50mg
A benzothiazole derivative with anti-excitotoxic effects that acts by blocking the presynaptic release of glutamate, indirectly antagonizing glutamate receptors, and inactivating neuronal voltage-gated Na+ channels (ED50 = 2.3 μM); suppresses glutamate-induced seizures in rats (ED50 = 3.2 mg/kg) and displays neuroprotective effects in hypoxic animals (ED50 = 4 mg/kg)
Selleck Chemical LLC Acotiamide hydrochloride S4838-1g
Acotiamide Hydrochloride (YM-443 Z-338) is the hydrochloride salt form of acotiamide a prokinetic agent with gastrointestinal (GI) motility-enhancing activity It is a new orally active selective acetylcholinesterase inhibitor
Selleck Chemical LLC (S.R.S)-AHPC hydrochloride S1062-100mg
(S R S)-AHPC hydrochloride (VH032-NH2 VHL ligand 1) is the VH032-based VHL ligand that is applicable to the recruitment of the von Hippel-Lindau (VHL) protein (S R S)-AHPC hydrochloride can be connected to the ligand for protein by a linker to form PROTACs
Selleck Chemical LLC Irinotecan hydrochloride S5026-1g
Irinotecan (CPT-11 ( )-Irinotecan) hydrochloride is an inhibitor of Topoisomerase I (Topo I) that exhibits cytotoxicity in LoVo cells and HT-29 cells with IC50 of 15 8 M and 5 17 M respectively
Selleck Chemical LLC OTS514 hydrochloride
OTS514 is a highly potent TOPK(T-LAK cell-originated protein kinase) inhibitor with an IC50 value of 2 6 nM OTS514 induces cell cycle arrest and apoptosis
Medchemexpress LLC Ipatasertib dihydrochloride | 1396257-94-5 | 99.2% | 530.92 | 10 MG
Ipatasertib dihydrochloride is a highly selective and ATP-competitive pan-Akt inhibitor with IC50 values of 5 nM for Akt1, 18 nM for Akt2, and 8 nM for Akt3. It shows high selectivity for Akt1 over closely related kinases like PKA and p70S6K. In vivo, it is effective in xenograft models where Akt is activated due to genetic alterations, achieving tumor growth delay, stasis, or regression.
- Highly selective and ATP-competitive pan-Akt inhibitor
- Has IC50 values of 5 nM for Akt1, 18 nM for Akt2, and 8 nM for Akt3
- Shows over 600-fold selectivity for Akt1 against PKA, and 100-fold against p70S6K
- Effective in xenograft models where Akt is activated
- Achieves tumor growth delay, stasis, or regression in vivo
- Well tolerated in immunocompromised mice at therapeutic doses
- Enhances tumor growth inhibition in combination therapies