Oxazinanes
Medchemexpress LLC Tebanicline dihydrochloride | 209326-19-2 | 99.5% | C9H13Cl3N2O | 1 ML
Tebanicline dihydrochloride is a potent, orally effective analgesic that modulates neuronal nicotinic acetylcholine receptors (nAChRs). It exhibits high selectivity for neuronal nAChRs, acting as an agonist, and effectively inhibits cytisine binding to α4β2 neuronal nAChRs. This product is investigated for its potential in treating various types of pain and for its anxiolytic-like properties.
- Potent and orally effective analgesic.
- Highly selective for neuronal nAChRs.
- Shows efficacy in models of acute, persistent, chemical, and neuropathic pain.
- Investigated for anxiolytic-like activity.
Medchemexpress LLC M-PEG12-Br | 1620461-89-3 | C25H51BrO12 | 250 MG
m-PEG12-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is for research use only and not sold to patients. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Key component in the creation of PROTACs.
- Functions by connecting a ligand for an E3 ubiquitin ligase with a ligand for a target protein.
- Harnesses the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
Cayman Chemical DthreoPDMP hydrochloride
A glucosylceramide synthase inhibitor; inhibits glucosylceramide synthase by 50% at a 5 µM in an enzyme assay; the active component of racemic DL-threo-PDMP; inhibits the synthesis of glucosylceramide synthase and lactosylceramide in B16 melanoma cells at 25 µM; inhibits B4GALT6 and prevents lactosylceramide synthesis; inhibits ganglioside biosynthesis, reduces long-term potentiation (LTP) in mouse hippocampal CA1 neurons, and impairs learning in the four-pellet taking test in mice
TARGETMOL CHEMICALS INC VESAMICOL HYDROCHLORIDE 5MG
Also available in 2 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. Vesamicol hydrochloride ((±)-AH5183 hydrochloride) is a acetylcholine transport inhibitor. purity: 98%
TARGETMOL CHEMICALS INC FLUOXETINE HYDROCHLORIDE 200MG
Also available in 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Fluoxetine hydrochloride (Lilly110140) is the first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants. purity: 99%
Cayman Chemical EthylLNIO hydrochloride
A modestly selective NOS inhibitor with Ki values for inhibition of nNOS, eNOS, and iNOS of 5.3, 18, and 12 µM, respectively; however, does not show biologically significant selectivity for nNOS over eNOS, and instead favors iNOS (Ki/Km = 3.79, 5, and 0.96 µM, respectively)
Sigma Aldrich Fine Chemicals Biosciences Butan 3 one 2 yl butanoate5KG
Butan 3 one 2 yl butanoate5KG
Apexbio Technology LLC EPZ020411 hydrochloride 2070015-25-5 1mg
EPZ020411 hydrochloride (CAS 2070015-25-5) is a potent and selective inhibitor of protein arginine methyltransferase 6 (PRMT6) exhibiting an IC of approximately 10 nM By specifically inhibiting the catalytic activity of PRMT6 EPZ020411 hydrochloride reduces methylation at arginine 2 of histone H3 (H3R2) thereby modulating gene expression The compound demonstrates high selectivity with minimal inhibition of other PRMT family members resulting in reduced off-target activity EPZ020411 hydrochloride is utilized in research exploring the roles of PRMT6 in cancer inflammation and other disease models
Apexbio Technology LLC Pargyline (hydrochloride) 306-07-0 5g
Pargyline (hydrochloride) (CAS 306-07-0) is an irreversible non-selective inhibitor of monoamine oxidases (MAO) targeting both MAO-A (IC 11 52 nM) and MAO-B (IC 8 2 nM) MAO-A predominantly deaminates neurotransmitters such as melatonin serotonin norepinephrine and epinephrine while MAO-B primarily acts on certain catecholamines In vitro pargyline inhibits proliferation and induces G1 phase cell cycle arrest and apoptosis in human prostate carcinoma (LNCaP-LN3) cells In vivo studies in rats have shown that pargyline administration increases striatal extracellular dopamine levels and decreases MAO-derived metabolites These properties support its utility in neuropharmacological and oncology research
![eMolecules Synthonix tert-butyl N-[(1R2S)-2-aminocyclobutyl]carbamate 1g 808545757 B84262 1932344-68-7 [null] 186.255 C9H18N2O2](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502694490.jpg-250.jpg)
eMolecules Synthonix tert-butyl N-[(1R2S)-2-aminocyclobutyl]carbamate 1g 808545757 B84262 1932344-68-7 [null] 186.255 C9H18N2O2
Synthonix tert-butyl N-[(1R2S)-2-aminocyclobutyl]carbamate 1g 808545757 B84262 1932344-68-7 [null] 186.255 C9H18N2O2
TARGETMOL CHEMICALS INC DROXIDOPA 25MG
Also available in 1 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Droxidopa (L-DOPS) is an orally available prodrug of norepinephrine that is used in the treatment of symptomatic orthostatic hypotension due to neurogenic causes of autonomic failure. purity: 99%
eMolecules Glycinamide hydrochloride | Combi-Blocks | 1668-10-6 | MFCD00013008 | 110.540 | C2H7ClN2O | 98.000 | Cl.NCC(N)=O | 25g | 205411604
Glycinamide hydrochloride | Combi-Blocks | 1668-10-6 | MFCD00013008 | 110.540 | C2H7ClN2O | 98.000 | Cl.NCC(N)=O | 25g | 205411604
Cayman Chemical HA1077 hydrochloride
A potent inhibitor of ROCK2, PRK-2, MSK1, and MAPKAP-K1b with IC50 values of 1.9, 4, 5, and 15 µM, respectively; has been shown to reduce blood vessel constriction, decreases pulmonary arterial pressure, inhibit tumor angiogenesis, and improve insulin signaling in a diabetic rat model; drug forms are marketed for the treatment of pulmonary arterial hypertension and stable angina
Apexbio Technology LLC Tacrine hydrochloride 1684-40-8 10mM (in 1mL H2O)
Tacrine hydrochloride (CAS 1684-40-8) is a small molecule inhibitor of cholinesterases exhibiting potent inhibitory activity against both acetylcholinesterase (AChE IC 31 nM) and butyrylcholinesterase (BChE IC 25 6 nM) in vitro Additionally it has been shown to inhibit N-methyl-D-aspartate receptors (NMDARs) with an IC of approximately 26 M By modulating both cholinergic and glutamatergic signaling pathways tacrine hydrochloride is frequently employed in studies investigating the molecular mechanisms underlying Alzheimer s disease and exploring potential therapeutic strategies for neurodegenerative disorders
eMolecules Ambeed / 22-Disulfanediyldiethanamine dihydrochloride / 25mg / 718039361 / A210400 / / 56-17-7 / MFCD00012905 / 225.190 / C4H14Cl2N2S2
Ambeed / 22-Disulfanediyldiethanamine dihydrochloride / 25mg / 718039361 / A210400 / / 56-17-7 / MFCD00012905 / 225.190 / C4H14Cl2N2S2