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CAS 1198080-53-3. 250mg. 1-(2R)-1-[(11bR)-Dinaphtho[21-d12-f][132]dioxaphosphepin-4-yloxy]propan-2-yl-3-phenylurea min. 97% UREAPhos. MFCD18827627. Molecular Weight 508.50. Molecular Formula C30H25N2O4P. Color/form white pwdr. Strem 15-2200. http//www.strem.com/catalog/v/15-2200/
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CAS 1198080-55-5. 250mg. 1-(1R2S)-1-[(11bR)-Dinaphtho[21-d12-f][132]dioxaphosphepin-4-yloxy]-1-phenylpropan-2-yl-3-phenylurea min. 97%. MFCD18827629. Molecular Weight 584.60. Molecular Formula C36H29N2O4P. Color/form white pwdr. Strem 15-2202. http//www.strem.com/catalog/v/15-2202/
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CAS 1357562-63-0. 250mg. 1-(2S)-1-[(11bS)-26-Dimethyldinaphtho[21-d12-f][132]dioxaphosphepin-4-yloxy]propan-2-yl-3-phenylurea min. 97%. MFCD18827630. Molecular Weight 536.56. Molecular Formula C32H29N2O4P. Color/form white pwdr. Strem 15-2204. http//www.strem.com/catalog/v/15-2204/
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PJ34 hydrochloride (CAS 344458-15-7) is a small molecular inhibitor targeting poly(ADP-ribose) polymerase (PARP) an enzyme critical for DNA repair and cellular proliferation In vitro assays demonstrate dose-dependent inhibition of purified PARP activity with an EC50 of approximately 20 nM Unlike other inhibitors such as 3-aminobenzamide (3-AB) PJ34 lacks antioxidant properties and exhibits significantly higher inhibitory potency against PARP Experimental studies have shown PJ34 protects against peroxynitrite-induced cell necrosis (EC50 20 nM) and dose-dependently suppresses proliferation in HepG2 liver cancer cell lines enhancing chemotherapeutic efficacy and conferring neuroprotection in various disease models
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KN-93 hydrochloride (CAS 1956426-56-4) is a selective inhibitor of Ca2 /calmodulin-dependent protein kinase II (CaMK II) binding competitively at the calmodulin site with a reported Ki of 0 37 M and an IC50 of 370 nM In isolated gastric parietal cells KN-93 suppresses acid secretion stimulated by carbachol and histamine with IC50 values of 0 15 M and 0 3 M respectively and inhibits mucin-stimulated aminopyrine uptake (IC50 0 6 M) Additionally KN-93 shows inhibitory activity against H /K -ATPase and directly blocks voltage-gated potassium (Kv) channels by promoting C-type inactivation KN-93 is widely used to probe CaMK II signaling and its downstream physiological effects in cellular and electrophysiological studies
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KN-93 hydrochloride (CAS 1956426-56-4) is a selective inhibitor of Ca2 /calmodulin-dependent protein kinase II (CaMK II) binding competitively at the calmodulin site with a reported Ki of 0 37 M and an IC50 of 370 nM In isolated gastric parietal cells KN-93 suppresses acid secretion stimulated by carbachol and histamine with IC50 values of 0 15 M and 0 3 M respectively and inhibits mucin-stimulated aminopyrine uptake (IC50 0 6 M) Additionally KN-93 shows inhibitory activity against H /K -ATPase and directly blocks voltage-gated potassium (Kv) channels by promoting C-type inactivation KN-93 is widely used to probe CaMK II signaling and its downstream physiological effects in cellular and electrophysiological studies
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