Oxolanes
(Tetrahydrofuran-2-yl)acetonitrile 98.0+%, TCI America™
CAS: 33414-62-9 Molecular Formula: C6H9NO Molecular Weight (g/mol): 111.144 MDL Number: MFCD03206782 InChI Key: LSCVJPYMXOAEPX-UHFFFAOYSA-N Synonym: Tetrahydrofurfurylcarbonitrile, 2-(Cyanomethyl)tetrahydrofuran PubChem CID: 4962721 IUPAC Name: 2-(oxolan-2-yl)acetonitrile SMILES: C1CC(OC1)CC#N
1,2:5,6-Di-O-isopropylidene-alpha-D-allofuranose 98.0+%, TCI America™
CAS: 2595-05-3 Molecular Formula: C12H20O6 Molecular Weight (g/mol): 260.29 MDL Number: MFCD00135634 InChI Key: KEJGAYKWRDILTF-VVULQXIFSA-N Synonym: 1,2:5,6-di-o-isopropylidene-alpha-d-allofuranose,3ar,5s,6r,6ar-5-r-2,2-dimethyl-1,3-dioxolan-4-yl-2,2-dimethyltetrahydrofuro 2,3-d 1,3 dioxol-6-ol,1,2,5,6-di-o-isopropylidene-alpha-d-allofuranose,3ar,5s,6r,6ar-5-4r-2,2-dimethyl-1,3-dioxolan-4-yl-2,2-dimethyl-tetrahydrofuro 2,3-d 1,3 dioxol-6-ol,1,2:5,6-bis-o-1-methylethylidene,5,6-di-o-isopropylidene-alpha-d-allofuranose,1,2:5,6-di-o-isopropylidene-?-d-allofuranose,1,2:5,6-di-o-isopropylidene-alpha-d-ribo-hexofuranose,1-o,2-o:5-o,6-o-diisopropylidene-alpha-d-allofuranose PubChem CID: 7157054 IUPAC Name: (3aR,5S,6R,6aR)-5-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-6-ol SMILES: CC1(OCC(O1)C2C(C3C(O2)OC(O3)(C)C)O)C
3-Aminotetrahydrofuran 97.0+%, TCI America™
CAS: 88675-24-5 Molecular Formula: C4H9NO Molecular Weight (g/mol): 87.122 MDL Number: MFCD07778394 InChI Key: MIPHRQMEIYLZFZ-UHFFFAOYSA-N PubChem CID: 3365553 IUPAC Name: oxolan-3-amine SMILES: C1COCC1N
Sigma Aldrich 4-Methoxy-6-methyl-2H-pyran-2-one
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich Borane-ammonia complex
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich Diacetone acrylamide
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich 6,7-Dimethylquinoline-3-carboxylic acid
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich 5-Bromo-2-nitroanisole
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich 3-Aminotetrahydrofuran
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Chem-Impex International, Inc. 2,3,5,6-Di-O-isopropylidene-a-D-mannofuranose | MFCD00134206 | 5G
2,3,5,6-Di-O-isopropylidene-a-D-mannofuranose, MFCD00134206, 5G
Sigma Aldrich Fine Chemicals Biosciences filipin complex from Strep50MG
Chemical structure macrolide
Chem-Impex International, Inc. Diacetone-D-glucose | 14686-89-6 | MFCD00005544 | 250G
Diacetone-D-glucose, 14686-89-6, MFCD00005544, 250G
Medchemexpress LLC KTX-582 | 2573298-13-0 | 98.7% | 872.93 | 5 MG
KTX-582 is a potent IRAK4 degrader that can induce apoptosis in MYD88MT DLBCL and is efficient in inducing in vivo tumor regressions in a lymphoma model. It degrades IRAK4 in whole blood monocytes and lymphocytes with high potency.
- Potent IRAK4 degrader with DC50 values of 4 nM for IRAK4 and 5 nM for Ikaros
- Induces apoptosis in MYD88MT DLBCL
- Efficient in inducing in vivo tumor regressions in a lymphoma model
- Degrades IRAK4 in whole blood monocytes and lymphocytes with IC50s of less than 0.05 μM
- Inhibits IRAK4 in human whole blood LPS TNFα with an IC50 of 0.05 to 1 μM
- Exhibits antiproliferative activity against human OCI-Ly10 cells (IC50: 14 nM)