Piperazines

Organic heterocyclic compounds that consist of a six-membered ring with four carbon atoms and two nitrogen atoms at opposite positions in the ring.

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2,626 – 2,640 of 4,118 results

2,626

Apexbio Technology LLC L-NIO dihydrochloride 159190-44-0 10mg

L-NIO dihydrochloride (CAS 159190-44-0) is a potent inhibitor of nitric oxide synthase (NOS) targeting inducible (iNOS) endothelial (eNOS) and neuronal (nNOS) isoforms with an IC50 of 65 M By blocking NOS activity L-NIO reduces nitric oxide (NO) production in activated macrophages and neutrophils which can influence both tumor cell cytotoxicity and inflammatory responses In vitro and in vivo studies demonstrate that L-NIO modulates vascular responses preventing immune complex-induced vasculitis and counteracting hypotensive effects triggered by acetylcholine and bradykinin This compound is widely utilized to investigate the role of NO in inflammation vascular regulation and immune-mediated tissue injury

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2,627

Selleck Chemical LLC E6446 dihydrochloride

E6446 dihydrochloride is a specific Toll-like receptor 9 inhibitor

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2,628

Apexbio Technology LLC nor-Binaltorphimine dihydrochloride 113158-34-2 10mg

nor-Binaltorphimine dihydrochloride (CAS 113158-34-2) is a highly selective antagonist of the -opioid receptor By inhibiting -opioid receptor-mediated signaling pathways this compound modulates processes such as nociceptive transmission and regulation of affective states Its selectivity enables precise investigation of -opioid receptor function in experimental models nor-Binaltorphimine dihydrochloride is widely utilized in pain research and neuroscience to elucidate the physiological and behavioral roles of -opioid receptor signaling

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2,629

Selleck Chemical LLC H-1152 dihydrochloride

H-1152 dihydrochloride (2HCl) is a membrane-permeable and selective inhibitor of Rho-associated protein kinase (ROCK) H-1152 inhibits ROCK2 PKA PKC PKG AuroraA and CaMK2 with IC50 of 0 0120 M 3 03 M 5 68 M 0 360 M 0 745 M and 0 180 M respectively

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2,630

eMolecules 883231-25-2 | (2-((tert-Butoxycarbonyl)amino)pyrimidin-5-yl)boronic acid | Synthonix | MFCD16251533 | 239.040 | C9H14BN3O4 | 95.000 | CC(C)(C)OC(=O)Nc1ncc(cn1)B(O)O | 250mg | 649432476

(2-((tert-Butoxycarbonyl)amino)pyrimidin-5-yl)boronic acid | Synthonix | 883231-25-2 | MFCD16251533 | 239.040 | C9H14BN3O4 | 95.000 | CC(C)(C)OC(=O)Nc1ncc(cn1)B(O)O | 250mg | 649432476

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2,631

Apexbio Technology LLC CP 31398 dihydrochloride 1217195-61-3 10mg

CP 31398 dihydrochloride (CAS 1217195-61-3) is a small molecule that modulates the tumor suppressor protein p53 by stabilizing both wild-type and mutant forms thereby promoting p53-dependent transcriptional activity Through p53 pathway activation CP 31398 dihydrochloride increases p21 expression inhibits G1/S-phase cyclin-dependent kinase complexes and induces apoptosis in multiple cancer cell lines irrespective of p53 mutation status In various models including head and neck squamous cell carcinoma and colon adenocarcinoma it has demonstrated the ability to inhibit cancer cell proliferation and enhance the cytotoxic effects of chemotherapeutic agents Combined administration with celecoxib has been shown to significantly reduce both incidence and multiplicity of colon tumors in preclinical studies supporting its utility in cancer research and therapeutic strategy development

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2,632

Selleck Chemical LLC Mirodenafil Dihydrochloride

Mirodenafil Dihydrochloride(SK-3530 dihydrochloride) is an oral phosphodiesterase type 5 (PDE-5) inhibitor used to treat erectile dysfunction (ED)

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2,633

Apexbio Technology LLC PI-103 Hydrochloride 371935-79-4 5mg

PI-103 Hydrochloride (CAS 371935-79-4) is a dual inhibitor targeting class I phosphatidylinositide 3-kinases (PI3K) and mammalian target of rapamycin (mTOR) It selectively inhibits PI3K isoforms p110 p110 p110 and mTOR with reported IC50 values of 0 002 M 0 003 M 0 003 M and 0 030 M respectively PI-103 effectively blocks the PI3K/Akt/mTOR pathway which is centrally involved in cell proliferation and survival signaling and is frequently dysregulated in cancer In various cellular models including leukemia hepatocellular carcinoma glioblastoma and neuroblastoma PI-103 suppresses pathway activation and inhibits cell proliferation It is widely used for investigating PI3K/Akt/mTOR signaling in oncology research

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2,634

Apexbio Technology LLC KX2-391 dihydrochloride 1038395-65-1 5mg

KX2-391 dihydrochloride (CAS 1038395-65-1) is an orally bioavailable small molecule that inhibits Src tyrosine kinase through selective interaction with the peptide substrate binding site rather than the ATP-binding site By blocking this non-catalytic domain KX2-391 disrupts Src kinase-mediated signaling pathways involved in tumor cell proliferation and metastatic processes Src kinases are frequently upregulated in various malignancies underscoring their importance in cancer biology KX2-391 is widely utilized in preclinical studies investigating Src-driven mechanisms of oncogenesis and tumor progression

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2,635

Apexbio Technology LLC KX2-391 dihydrochloride 1038395-65-1 250mg

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2,636

Apexbio Technology LLC L-NIO dihydrochloride 159190-44-0 5mg

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2,637

Selleck Chemical LLC Dexrazoxane

Dexrazoxane (ICRF-187) is an anticancer drug able to block mitosis and to arrest dividing cells It is an iron chelator and provides cardioprotection against anthracycline toxicity

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2,638

eMolecules 885270-31-5 | 1-((benzyloxy)carbonyl)-3-((tert-butoxycarbonyl)amino)piperidine-3-carboxylic acid | Advanced ChemBlocks | MFCD04114485 | 378.425 | C19H26N2O6 | 97.000 | CC(C)(C)OC(=O)NC1(CCCN(C1)C(=O)OCc1ccccc1)C(O)=O | 250mg | 718021672

1-((benzyloxy)carbonyl)-3-((tert-butoxycarbonyl)amino)piperidine-3-carboxylic acid | Advanced ChemBlocks | 885270-31-5 | MFCD04114485 | 378.425 | C19H26N2O6 | 97.000 | CC(C)(C)OC(=O)NC1(CCCN(C1)C(=O)OCc1ccccc1)C(O)=O | 250mg | 718021672

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2,639

eMolecules 1373273-46-1 | {1-[(tert-Butoxy)carbonyl]pyrrolo[3,2-b]pyridin-2-yl}boronic acid | Combi-Blocks, Inc. | MFCD30182376 | 262.070 | C12H15BN2O4 | 98.000 | CC(C)(C)OC(=O)n1c(cc2ncccc12)B(O)O | 250mg | 848836681

{1-[(tert-Butoxy)carbonyl]pyrrolo[3,2-b]pyridin-2-yl}boronic acid | Combi-Blocks, Inc. | 1373273-46-1 | MFCD30182376 | 262.070 | C12H15BN2O4 | 98.000 | CC(C)(C)OC(=O)n1c(cc2ncccc12)B(O)O | 250mg | 848836681

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2,640

eMolecules 886766-60-5 | 2-Phenylpiperazine, N1-BOC protected | Apollo Scientific US | MFCD07367734 | 262.353 | C15H22N2O2 | 95.000 | CC(C)(C)OC(=O)N1CCNCC1c1ccccc1 | 250mg | 571000862

2-Phenylpiperazine, N1-BOC protected | Apollo Scientific US | 886766-60-5 | MFCD07367734 | 262.353 | C15H22N2O2 | 95.000 | CC(C)(C)OC(=O)N1CCNCC1c1ccccc1 | 250mg | 571000862

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Piperazines

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