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Piperazines

Organic heterocyclic compounds that consist of a six-membered ring with four carbon atoms and two nitrogen atoms at opposite positions in the ring.

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1

Medchemexpress LLC P53 and MDM2 proteins-interaction-inhibitor (chiral) | 939981-37-0 | 98.1% | C40H49Cl2N5O4 | 50 MG
SDP

The p53 and MDM2 proteins-interaction-inhibitor (chiral) is a high-purity chemical compound with a purity of 98.1%. This compound, identified by its chemical formula C40H49Cl2N5O4, functions as an inhibitor of the interaction between p53 and MDM2 proteins. It is supplied as a white to off-white solid, with specific storage requirements for both powder and solution forms to maintain its stability and efficacy.

  • Purity: 98.1%
  • Chemical formula: C40H49Cl2N5O4
  • Molecular weight: 734.75
  • Appearance: White to off-white solid
  • Powder storage: -20°C for 3 years, 4°C for 2 years
  • In solvent storage: -80°C for 2 years, -20°C for 1 year
  • Solubility in vitro: DMSO: 50 mg/mL (68.05 mM)

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2

Medchemexpress LLC HY-70027 10mg Medchemexpress, p53 and MDM2 proteins-interaction-inhibitor (chiral) CAS:939981-37-0 Purity:>98%
SDP

Medchemexpress, HY-70027 10mg p53 and MDM2 proteins-interaction-inhibitor (chiral) CAS:939981-37-0 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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3

eMolecules​ Pharmablock tert-butyl 3-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]propanoate 250mg 840484257 PBY0730 0 000 782475-37-0 MFCD22574821 341 242 C13H25BrO5

Pharmablock tert-butyl 3-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]propanoate 250mg 840484257 PBY0730 0 000 782475-37-0 MFCD22574821 341 242 C13H25BrO5

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4

Accela Chembio Inc 1-[3-(4-methylpiperazin-1-yl)phenyl]methanamine | 5g | 672325-37-0 | MFCD07368540 | 95+% | Shelf Life: 1620 Days | Light Sensitive/air Sensitive/+4
SDP

1-[3-(4-methylpiperazin-1-yl)phenyl]methanamine | 5g | 672325-37-0 | MFCD07368540 | 95+% | Shelf Life: 1620 Days | Light Sensitive/air Sensitive/+4

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5

Apexbio Technology LLC E-4031 dihydrochloride 113559-13-0 50mg
SDP

E-4031 dihydrochloride (CAS 113559-13-0) is a methanesulfonanilide compound classified as a class III antiarrhythmic agent It selectively inhibits ether- -go-go-related gene (ERG) family potassium channels including hERG (Kv11 1) with an IC50 of 29 nM and demonstrates binding affinities of 99 116 and 193 nM for ERG1 ERG2 and ERG3 respectively By blocking these voltage-gated K channels E-4031 dihydrochloride extends cardiac action potential duration and modulates inwardly rectifying potassium currents in myocardial and gastrointestinal cells This molecule is widely used to study ERG channel physiology arrhythmogenesis and pharmacological rescue of mutant hERG in long QT syndrome type 2

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6

Apexbio Technology LLC E-4031 dihydrochloride 113559-13-0 5mg
SDP

E-4031 dihydrochloride (CAS 113559-13-0) is a methanesulfonanilide compound classified as a class III antiarrhythmic agent It selectively inhibits ether- -go-go-related gene (ERG) family potassium channels including hERG (Kv11 1) with an IC50 of 29 nM and demonstrates binding affinities of 99 116 and 193 nM for ERG1 ERG2 and ERG3 respectively By blocking these voltage-gated K channels E-4031 dihydrochloride extends cardiac action potential duration and modulates inwardly rectifying potassium currents in myocardial and gastrointestinal cells This molecule is widely used to study ERG channel physiology arrhythmogenesis and pharmacological rescue of mutant hERG in long QT syndrome type 2

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7

Apexbio Technology LLC E-4031 dihydrochloride 113559-13-0 10mg
SDP

E-4031 dihydrochloride (CAS 113559-13-0) is a methanesulfonanilide compound classified as a class III antiarrhythmic agent It selectively inhibits ether- -go-go-related gene (ERG) family potassium channels including hERG (Kv11 1) with an IC50 of 29 nM and demonstrates binding affinities of 99 116 and 193 nM for ERG1 ERG2 and ERG3 respectively By blocking these voltage-gated K channels E-4031 dihydrochloride extends cardiac action potential duration and modulates inwardly rectifying potassium currents in myocardial and gastrointestinal cells This molecule is widely used to study ERG channel physiology arrhythmogenesis and pharmacological rescue of mutant hERG in long QT syndrome type 2

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8

Apexbio Technology LLC PI-1840 1401223-22-0 10mg
SDP

PI-1840 (CAS 1401223-22-0) is a potent selective and rapidly reversible noncovalent inhibitor of the proteasome chymotrypsin-like (CT-L) activity It exhibits an IC50 of 27 nM against CT-L catalytic function of the proteasome with significantly greater selectivity over other proteolytic activities including PGPH-L and T-L In MDA-MB-468 human breast cancer cells PI-1840 inhibits CT-L activity (IC50 0 37 M) suppresses cell viability and proliferation and induces accumulation of CT-L substrates such as I B- p27 and Bax ultimately triggering apoptosis via PARP cleavage and caspase-3 activation In vivo PI-1840 markedly reduces tumor growth in a breast cancer xenograft model This compound is valuable for investigating proteasome function apoptosis and cancer biology

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