Piperidines
Medchemexpress LLC Ropivacaine hydrochloride monohydrate | 132112-35-7 | 99.9% | 1 ML
Ropivacaine hydrochloride monohydrate is a potent sodium channel blocker that inhibits impulse conduction by reversibly blocking sodium ion influx in nerve fibers. It also acts as an inhibitor of K2P (two-pore domain potassium channel) TREK-1. This product is extensively used for regional anesthesia and the management of neuropathic pain in vivo.
- Potent sodium channel blocker
- Inhibits impulse conduction by blocking sodium ion influx
- Inhibitor of K2P (two-pore domain potassium channel) TREK-1
- Purity of 99.93%
- Appearance: white to off-white solid
- Recommended storage for solid: 4°C, sealed, away from moisture
- Recommended storage in solvent: -80°C for 6 months; -20°C for 1 month
Medchemexpress LLC Ropivacaine | 84057-95-4 | MFCD00078774 | 100.0% | 50 MG
Overview of Ropivacaine
Ropivacaine is a potent sodium channel blocker. It works by blocking impulse conduction through reversible inhibition of sodium ion influx in nerve fibers. Additionally, Ropivacaine acts as an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. It is utilized in the research of neuropathic pain management.
Features and Benefits
- Potent sodium channel blocker.
- Blocks impulse conduction by inhibiting sodium ion influx.
- Inhibits K2P TREK-1 (IC50 of 402.7 μM).
- Used for neuropathic pain management research.
- Epidural administration blocks neuropathic pain and delays its development.
- Inhibits pressure-induced increases in filtration coefficient.
- Prevents pressure-induced lung edema and hyperpermeability.
- Inhibits pressure-induced NO production.
Medchemexpress LLC Mepivacaine hydrochloride | 1722-62-9 | 99.7% | 1 ML
Mepivacaine hydrochloride binds to specific voltage-gated sodium ion channels in neuronal cell membranes, inhibiting both sodium influx and membrane depolarization. This blockage of nerve impulse initiation and conduction results in a reversible loss of sensation. It has a more rapid onset and moderate duration of action compared to other local anesthetics. It also displays a preferential use-dependent block of Na(v)1.8.
- Inhibits sodium influx and membrane depolarization
- Results in reversible loss of sensation
- Rapid onset of action
- Moderate duration of action
- Displays preferential use-dependent block of Na(v)1.8
Medchemexpress LLC Ropivacaine | 84057-95-4 | 100.0% | 5 MG
Ropivacaine is a potent sodium channel blocker that blocks impulse conduction by reversibly inhibiting sodium ion influx in nerve fibers. It also acts as an inhibitor of K2P (two-pore domain potassium channel) TREK-1. It is utilized in the research of neuropathic pain management.
- Blocks impulse conduction by reversibly inhibiting sodium ion influx in nerve fibers.
- Acts as an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane.
- Utilized in the research of neuropathic pain management.
Medchemexpress LLC Zidebactam | 1436861-97-0 | 100 MG
Zidebactam is a beta-lactamase inhibitor and a penicillin-binding protein 2 (PBP2) inhibitor supplied for laboratory research use. It is used to study beta-lactam resistance and to evaluate combination antibiotic therapies.
- Acts as a beta-lactamase inhibitor and PBP2 inhibitor.
- Reported PBP2 IC50 ≈ 0.26 μg/mL, suitable for potency benchmarking.
- Intended for in vitro research applications; not for human use.
- Useful for studying antibiotic resistance mechanisms and adjuvant therapies.
- Characterized by CAS 1436861-97-0 and molecular weight 391.40 g/mol.
eMolecules Medchem Express / Ropivacaine (mesylate) / 10mg / 527573892 / HY-B0563C / / 854056-07-8 / MFCD08458442 / 370.510 / C18H30N2O4S
Medchem Express / Ropivacaine (mesylate) / 10mg / 527573892 / HY-B0563C / / 854056-07-8 / MFCD08458442 / 370.510 / C18H30N2O4S
![eMolecules Avibactam sodium | Combi-Blocks | 1192491-61-4 | MFCD28900719 | 287.220 | C7H10N3NaO6S | 97.000 | [Na+].NC(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2OS([O-])(=O)=O | 1g | 415501240](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC3072086.JPG-250.jpg)
eMolecules Avibactam sodium | Combi-Blocks | 1192491-61-4 | MFCD28900719 | 287.220 | C7H10N3NaO6S | 97.000 | [Na+].NC(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2OS([O-])(=O)=O | 1g | 415501240
Avibactam sodium | Combi-Blocks | 1192491-61-4 | MFCD28900719 | 287.220 | C7H10N3NaO6S | 97.000 | [Na+].NC(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2OS([O-])(=O)=O | 1g | 415501240
Medchemexpress LLC HY-111381 10mg Medchemexpress, BI-3812 CAS:2166387-64-8 Purity:>98%
Medchemexpress, HY-111381 10mg BI-3812 CAS:2166387-64-8 BI-3812 is potent and efficacious BCL6 inhibitor, inhibiting the BTB domain of BCL6, with an IC50 of ≤3 nM; BI-3812 has antitumor activity. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Avibactam impurity 1 | 400626-71-3 | MFCD14635665 | 5g
Avibactam impurity 1 is an impurity of Avibactam (HY-14879)
TARGETMOL CHEMICALS INC AVIBACTAM SODIUM 50MG
Also available in 2 mg 5 mg 10 mg 25 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Avibactam sodium (NXL-104) is a reversible (beta)-lactamase inhibitor (IC50 8/80/38 nM for TEM-1/P99/KPC-2 (beta)-lactamases). purity: 99%
Medchemexpress LLC Revefenacin | 864750-70-9 | MFCD28386316 | 99.1% | 597.75 g·mol⁻¹ | C35H43N5O4 | 10 MG
Revefenacin is a long-acting muscarinic acetylcholine receptor antagonist (LAMA) with high affinity for the M3 receptor (Ki = 0.18 nM). This research-grade compound is supplied as a solid (white to off-white powder) for in vitro and preclinical studies; it is for research use only and not for clinical or human use.
- Potent M3 receptor antagonist (Ki = 0.18 nM).
- High chemical purity (99.09%).
- Solid, white to off-white appearance suitable for formulation or assay preparation.
- Soluble in DMSO (≈100 mg/mL); ultrasonic agitation recommended.
- Storage: powder at -20°C (long term) or 4°C (short term); in solvent at -80°C or -20°C.
Selleck Chemical LLC Mepivacaine HCl S3155-50mg
Mepivacaine is a tertiary amine used as a local anesthetic
Cayman Chemical Levobupivacaine hydrochlorid
A sodium channel blocker and local anesthetic; levorotary stereoisomer of bupivacaine; inhibits INa by 57.8% in isolated guinea pig ventricular myocytes at 10 μM; reduces the Vmax and action potential duration to 76.7 and 83.4% of controls, respectively, in isolated guinea pig papillary muscle at 10 μM; induces a complete block of proprioception, motor function, and nociception in the hindleg of rats at 7.7 mM by percutaneous injection into the sciatic nerve
Medchemexpress LLC GSK2879552 dihydrochloride | 1902123-72-1 | 99.8% | 437.40 | 100 MG
GSK2879552 dihydrochloride is an orally active, selective, and irreversible inhibitor of lysine specific demethylase 1 (LSD1/KDM1A), which has potential antineoplastic activity. For research use only, it is not sold to patients.
- Orally active.
- Selective and irreversible inhibitor of LSD1/KDM1A.
- Exhibits potential antineoplastic activity.
- Inhibits KDM1A histone demethylase activity, inducing differentiation of sorafenib-resistant cells and attenuating stemness properties in vitro.
- Depresses the transcription of Wnt antagonists and downregulates β-catenin signaling activity in sorafenib-resistant cells in vitro.
- In vivo treatment with 1.5 mg/kg exhibits tumor growth inhibition in SCLC xenograft bearing mice.
Medchemexpress LLC HY-101493 5mg Medchemexpress, SUN11602 CAS:704869-38-5 Purity:>98%
Medchemexpress, HY-101493 5mg SUN11602 CAS:704869-38-5 SUN11602 is a novel aniline compound with basic fibroblast growth factor-like activity. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.