Piperidines
Medchemexpress LLC HY-114926 5mg Medchemexpress, KT185 CAS:1472640-86-0 Purity:>98%
Medchemexpress, HY-114926 5mg KT185 CAS:1472640-86-0 KT185 is an orally-bioavailable, brain-penetrant and selective ABHD6 inhibitor, with an IC 50 0.21 nM in Neuro2A cells [1] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
eMolecules Medchem Express / Alvimopan (dihydrate) / 5mg / 446271508 / HY-76657A / / 170098-38-1 / MFCD00927248 / 460.571 / C25H36N2O6
Medchem Express / Alvimopan (dihydrate) / 5mg / 446271508 / HY-76657A / / 170098-38-1 / MFCD00927248 / 460.571 / C25H36N2O6
eMolecules Medchem Express / JNJ-42153605 / 5mg / 446268916 / HY-18162 / / 1254977-87-1 / MFCD22199231 / 400.449 / C22H23F3N4
Medchem Express / JNJ-42153605 / 5mg / 446268916 / HY-18162 / / 1254977-87-1 / MFCD22199231 / 400.449 / C22H23F3N4
Medchemexpress LLC Piperine | 94-62-2 | 98.99% | 285.34 | 100 G
Piperine is an alkaloid isolated from pepper. It can inhibit the activity of P-glycoprotein and CYP3A4, and inhibits HeLa cells with an IC50 of 61.94±0.054 μg/mL.
- Alkaloid isolated from pepper.
- Inhibits the activity of P-glycoprotein and CYP3A4.
- Inhibits HeLa cells with an IC50 of 61.94±0.054 μg/mL.
- Shown to possess in vitro cytotoxic activity.
- Immunomodulatory, anti-oxidant, anti-asthmatic, anti-carcinogenic, anti-inflammatory, anti-ulcer, and anti-amoebic properties.
- Enhances the bioavailabilities of other drugs, including rosuvastatin, puerarin, and docetaxel (DOX) by inhibiting CYP3A and P-glycoprotein activity.
- Inhibits the phosphorylation of I-κB, p65, p38, ERK, and JNK in a dose-dependent manner, suggesting potential as an anti-inflammatory drug.
Apexbio Technology LLC Piperine 94-62-2 200mg
Piperine (CAS 94-62-2) is an alkaloid primarily found in black pepper (Piper nigrum) that has demonstrated diverse pharmacological activities It modulates several signaling pathways including inhibition of drug-metabolizing enzymes such as CYP3A4 and P-glycoprotein and affects cellular processes through regulation of MAPK and Akt phosphorylation Piperine has been studied for its potential to enhance the bioavailability of various therapeutic agents and for its anti-inflammatory anti-tumor and neuroprotective properties This compound is utilized in biomedical research to investigate drug-drug interactions signal transduction mechanisms and its impact on cellular proliferation and apoptosis
Medchemexpress LLC Pomalidomide-PEG4-C2-NH2 hydrochloride | 2357105-92-9 | 98.2% | 528.98 | 100 MG
Pomalidomide-PEG4-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate. It incorporates a Pomalidomide-based cereblon ligand and a 4-unit PEG linker, which are utilized in the synthesis of PROTACs. PROTACs themselves consist of two different ligands linked together, one targeting an E3 ubiquitin ligase and the other a protein of interest. Their function is to leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Pomalidomide-based cereblon ligand
- Contains a 4-unit PEG linker
- Used in the synthesis of PROTACs
- For research use only
Medchemexpress LLC AS-99 TFA | 3115178-55-4 | 99.2% | C29H31F6N5O5S2 | 100 MG
AS-99 TFA is a first-in-class, potent, and selective ASH1L histone methyltransferase inhibitor with anti-leukemic activity. It blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces the leukemia burden in vivo.
- Potent and selective ASH1L histone methyltransferase inhibitor
- Exhibits anti-leukemic activity
- Blocks cell proliferation
- Induces apoptosis and differentiation
- Downregulates MLL fusion target genes
- Reduces leukemia burden in vivo
- Shows over 100-fold selectivity towards ASH1L
Chem-Impex International, Inc. Boc-nortropinone | 185099-67-6 | MFCD00673779 | 25G
Boc-nortropinone, 185099-67-6, MFCD00673779, 25G
Medchemexpress LLC HY-101488 10mg Medchemexpress, CC-885 CAS:1010100-07-8 Purity:>98%
Medchemexpress, HY-101488 10mg CC-885 CAS:1010100-07-8 CC-885 is a cereblon (CRBN) modulator with potent anti-tumour activity. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Enzo Life Sciences Arv-825 (5mg). CAS: 1818885-28-7
ARV-825 is a PROTAC targeting on BRD4, consisting of a BRD4-ligand JQ-1 linked to a cereblon E3 ligase ligand Pomalidomide, with Kds values of 90nM and 28nM for affinity to BD1 and BD2. Purity: ≥98%. Long Term Storage: -20°C.
Medchemexpress LLC HY-B0750 5mg Medchemexpress, Dolasetron CAS:115956-12-2 Purity:>98%
Medchemexpress, HY-B0750 5mg Dolasetron CAS:115956-12-2 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-50667 50mg Medchemexpress, Apixaban CAS:503612-47-3 Purity:>98%
Medchemexpress, HY-50667 50mg Apixaban CAS:503612-47-3 Apixaban (BMS-562247-01) is a highly selective, reversible and orally active inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively. Apixaban is in development for the prevention and treatment of various thromboembolic diseases[2]. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
![eMolecules 6-hydroxy-2-azabicyclo[2.2.2]octane hydrochloride | 128573-76-2 | MFCD27956882 | 1g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502157276.JPG-250.jpg)
eMolecules 6-hydroxy-2-azabicyclo[2.2.2]octane hydrochloride | 128573-76-2 | MFCD27956882 | 1g
Pharmablock | 6-hydroxy-2-azabicyclo[2.2.2]octane hydrochloride | 1g | 551207397 | PB05560 | | 128573-76-2 | MFCD27956882 | 163.650 | C7H14ClNO
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Medchemexpress LLC Pomalidomide-C12-NH2 hydrochloride | 2862774-02-3 | 97.1% | C25H37ClN4O4 | 10MG
Pomalidomide-C12-NH2 hydrochloride is an E3 ligase ligand-linker conjugate that serves as the Cereblon-binding component in PROTAC constructs targeting KRAS G12C. Supplied as the hydrochloride salt, it is provided as a solid for use in targeted protein degradation research and biochemical assay development.
- E3 ligase ligand-linker conjugate suitable for Cereblon-based PROTAC design.
- Hydrochloride salt form; solid, light yellow to green yellow appearance.
- High purity (97.1%).
- Molecular formula C25H37ClN4O4; molecular weight 493.04 g·mol⁻1.
- Recommended storage at -20°C; protect from light.
- Available in small research sizes (5-500 mg).