Piperidines
Medchemexpress LLC HY-103618 10mg Medchemexpress, THZ531 CAS:1702809-17-3 Purity:>98%
Medchemexpress, HY-103618 10mg THZ531 CAS:1702809-17-3 THZ531 is a selective and covalent inhibitor of both CDK12 and CDK13 with IC50s of 158 nM and 69 nM, respectively. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
![Sigma Aldrich 5-Methyl-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde](https://assets.fishersci.com/TFS-Assets/CCG/Sigma-Aldrich/product-images/764388b3-fe97-4d36-83ab-cbaff197b95b.jpg-250.jpg)
Sigma Aldrich 5-Methyl-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Apexbio Technology LLC AT7867 857531-00-1 5mg
AT7867 (CAS 857531-00-1) is a small molecule ATP-competitive inhibitor that targets Akt1 Akt2 Akt3 p70S6 kinase (p70S6K) and protein kinase A (PKA) with reported IC50 values of 32 nM 17 nM 47 nM 85 nM and 20 nM respectively Akt or protein kinase B is a serine/threonine kinase involved in cellular pathways such as glucose metabolism apoptosis proliferation transcription and migration AT7867 suppresses proliferation across various human tumor cell lines including MES-SA MDA-MB-468 MCF-7 HCT116 and HT29 with IC50 values ranging from 0 9 to 3 M Additionally it inhibits GSK3 within these lines (IC50 2 4 M) and induces apoptosis in U87MG glioblastoma cells via dose- and time-dependent Akt pathway inhibition In PTEN-deficient tumor xenograft models AT7867 reduces phosphorylation of Akt/p70S6K substrates and impedes tumor growth supporting its use in cancer research